About: Cyclobenzaprine

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An Entity of Type : http://linked.opendata.cz/ontology/drugbank/Drug, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	http://linked.opendata.cz/ontology/drugbank/Drug
http://linked.open...gbank/description	Cyclobenzaprine is a skeletal muscle relaxant and a central nervous system (CNS) depressant. Cyclobenzaprine acts on the locus coeruleus where it results in increased norepinephrine release, potentially through the gamma fibers which innervate and inhibit the alpha motor neurons in the ventral horn of the spinal cord. It is structurally similar to Amitriptyline, differing by only one double bond. (en)
http://linked.open...y/drugbank/dosage	http://linked.opendata.cz/resource/drugbank/dosage/271B61CE-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/dosage/271B61CF-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/dosage/271B61D0-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/dosage/271B61D1-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/dosage/271B61D2-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/dosage/271B61D3-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/dosage/271B61D4-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/dosage/271B61D5-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/dosage/271B61D6-363D-11E5-9242-09173F13E4C5
http://linked.open...gy/drugbank/group	approved (en)
http://linked.open...drugbank/halfLife	18 hours (range 8-37 hours) (en)
http://linked.open...ugbank/indication	For use as an adjunct to rest and physical therapy for relief of muscle spasm associated with acute, painful musculoskeletal conditions. (en)
http://linked.open...bank/manufacturer	Patheon Inc. Actavis totowa llc Aurobindo pharma ltd Pharmaceutical Utilization Management Program VA Inc. Invagen pharmaceuticals inc Hoffmann la roche inc Alphapharm Party Ltd. Amerisource Health Services Corp. Amkas Laboratories Inc. Cardinal Health Diversified Healthcare Services Inc. Lake Erie Medical and Surgical Supply Pfizer Inc. Physicians Total Care Inc.
sameAs	Cyclobenzaprine Cyclobenzaprine
Title	Cyclobenzaprine (en)
adms:identifier	http://linked.opendata.cz/resource/drugbank/drug/DB00924/identifier/chebi/3996 http://linked.opendata.cz/resource/drugbank/drug/DB00924/identifier/chemspider/2792 http://linked.opendata.cz/resource/drugbank/drug/DB00924/identifier/drugbank/DB00924 http://linked.opendata.cz/resource/drugbank/drug/DB00924/identifier/kegg-compound/C06931 http://linked.opendata.cz/resource/drugbank/drug/DB00924/identifier/national-drug-code-directory/0179-0057-30 http://linked.opendata.cz/resource/drugbank/drug/DB00924/identifier/pharmgkb/PA449160 http://linked.opendata.cz/resource/drugbank/drug/DB00924/identifier/pubchem-compound/2895 http://linked.opendata.cz/resource/drugbank/drug/DB00924/identifier/pubchem-substance/46508313 http://linked.opendata.cz/resource/drugbank/drug/DB00924/identifier/wikipedia/Cyclobenzaprine
http://linked.open...mechanismOfAction	Like other tricyclic antidepressants, cyclobenzaprine exhibits anticholinergic activity, potentiation of norepinephrine, and antagonism of reserpine. Cyclobenzaprine does not directly act on the neuromuscular junction or the muscle but relieves muscle spasms through a central action, possibly at the brain stem level. Cyclobenzaprine binds to the serotonin receptor and is considered a 5-HT2 receptor antagonist that reduces muscle tone by decreasing the activity of descending serotonergic neurons. (en)
http://linked.open...drugbank/packager	Meridian Medical Technologies Inc. Murfreesboro Pharmaceutical Nursing Supply Mylan Neuman Distributors Inc. Novopharm Ltd. Palmetto Pharmaceuticals Inc. Bryant Ranch Prepack Abic ltd Abraxis pharmaceutical products Amgen Inc. Comprehensive Consultant Services Inc. Pharmaceutical Utilization Management Program VA Inc. Abbott laboratories Prepak Systems Inc. Corepharma llc Genentech Inc. Genpharm LP H.J. Harkins Co. Inc. Heritage Pharmaceuticals Hi Tech Pharmacal Co. Inc. Pharmaceutical Utilization Management Program VA Inc. Advanced Pharmaceutical Services Inc. Aidarex Pharmacuticals LLC Amerisource Health Services Corp. Amneal Pharmaceuticals Apotheca Inc. AQ Pharmaceuticals Inc. A-S Medication Solutions LLC Aurobindo Pharma Ltd. Bedford Labs Breckenridge Pharmaceuticals Brighton Pharmaceuticals Bryant Ranch Prepack Pfizer Inc. Cardinal Health Cephalon Inc. Comprehensive Consultant Services Inc. Corepharma LLC Coupler Enterprises Inc. Dept Health Central Pharmacy DHHS Program Support Center Supply Service Center Direct Dispensing Inc. Dispensing Solutions Diversified Healthcare Services Inc. Dorx LLC ECR Pharmaceuticals Endo Pharmaceuticals Inc. Eurand Pharmaceuticals Inc. Fusion Pharmaceuticals LLC Golden State Medical Supply Inc. Sandoz Heartland Repack Services LLC APP Pharmaceuticals Atlantic Biologicals Corporation Actavis Group Advanced Pharmaceutical Services Inc. Amerisource Health Services Corp. Amneal Pharmaceuticals Abbott Laboratories Ltd.

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