About: Isosorbide Dinitrate

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An Entity of Type : http://linked.opendata.cz/ontology/drugbank/Drug, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	http://linked.opendata.cz/ontology/drugbank/Drug
http://linked.open...gbank/description	A vasodilator used in the treatment of angina pectoris. Its actions are similar to nitroglycerin but with a slower onset of action. [PubChem] (en)
http://linked.open...y/drugbank/dosage	http://linked.opendata.cz/resource/drugbank/dosage/271B579E-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/dosage/271B579F-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/dosage/271B57A0-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/dosage/271B57A1-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/dosage/271B57A2-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/dosage/271B57A3-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/dosage/271B57A4-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/dosage/271B57A5-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/dosage/271B57A6-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/dosage/271B57A7-363D-11E5-9242-09173F13E4C5
http://linked.open...gy/drugbank/group	approved (en)
http://linked.open...drugbank/halfLife	1 hour (en)
http://linked.open...ugbank/indication	For the prevention of angina pectoris due to coronary artery disease. (en)
http://linked.open...bank/manufacturer	Biovail laboratories inc Mutual pharmaceutical co inc Par pharmaceutical inc Sandoz inc Superpharm corp Ar holding co inc Pfizer chemicals div pfizer inc Aurobindo pharma usa inc Alcon laboratories inc Major Pharmaceuticals Murfreesboro Pharmaceutical Nursing Supply Astrazeneca pharmaceuticals lp Caraco pharmaceutical laboratories ltd Bausch and lomb inc
sameAs	Isosorbide Dinitrate Isosorbide Dinitrate
Title	Isosorbide Dinitrate (en)
adms:identifier	http://linked.opendata.cz/resource/drugbank/drug/DB00883/identifier/chebi/6061 http://linked.opendata.cz/resource/drugbank/drug/DB00883/identifier/chemspider/6619 http://linked.opendata.cz/resource/drugbank/drug/DB00883/identifier/drugbank/DB00883 http://linked.opendata.cz/resource/drugbank/drug/DB00883/identifier/kegg-compound/C07456 http://linked.opendata.cz/resource/drugbank/drug/DB00883/identifier/kegg-drug/D00516 http://linked.opendata.cz/resource/drugbank/drug/DB00883/identifier/national-drug-code-directory/0008-4139-01 http://linked.opendata.cz/resource/drugbank/drug/DB00883/identifier/pharmgkb/PA450125 http://linked.opendata.cz/resource/drugbank/drug/DB00883/identifier/pubchem-compound/6883 http://linked.opendata.cz/resource/drugbank/drug/DB00883/identifier/pubchem-substance/46506412
http://linked.open...mechanismOfAction	Similar to other nitrites and organic nitrates, isosorbide dinitrate is converted to nitric oxide (NO), an active intermediate compound which activates the enzyme guanylate cyclase (atrial natriuretic peptide receptor A). This stimulates the synthesis of cyclic guanosine 3',5'-monophosphate (cGMP) which then activates a series of protein kinase-dependent phosphorylations in the smooth muscle cells, eventually resulting in the dephosphorylation of the myosin light chain of the smooth muscle fiber. The subsequent release of calcium ions results in the relaxation of the smooth muscle cells and vasodilation. (en)
http://linked.open...drugbank/packager	Advanced Pharmaceutical Services Inc. Amerisource Health Services Corp. Apotex Inc. Apotheca Inc. APP Pharmaceuticals AQ Pharmaceuticals Inc. A-S Medication Solutions LLC Atlantic Biologicals Corporation Aurobindo Pharma Ltd. Baxter International Inc. Bedford Labs Ben Venue Laboratories Inc. Bryant Ranch Prepack Cardinal Health Ohm Laboratories Inc. Amerisource Health Services Corp. Bryant Ranch Prepack Atlantic Biologicals Corporation 3M Health Care Apotex Inc. A-S Medication Solutions LLC Abbott Laboratories Ltd. Alliance Medical Products Ben Venue Laboratories Inc. Ivax pharmaceuticals inc sub teva pharmaceuticals usa Catalent Pharma Solutions Cipla Ltd. Cobalt Pharmaceuticals Inc. Dey Pharma LP Dispensing Solutions Diversified Healthcare Services Inc. Sandoz Holopack International Corp. Actavis elizabeth llc Apotex inc etobicoke site Murfreesboro Pharmaceutical Nursing Supply Murfreesboro Pharmaceutical Nursing Supply Northstar Rx LLC Alphapharm Party Ltd. Apotex Inc. Bristol-Myers Squibb Co. Catalent Pharma Solutions Allan Pharmaceutical LLC Amerisource Health Services Corp. Sandoz Pharmaceutical Utilization Management Program VA Inc. Boehringer ingelheim pharmaceuticals inc Actavis mid atlantic llc Bausch and lomb pharmaceuticals inc Cobalt laboratories inc Dey lp Holopack international corp Kaiser Foundation Hospital
http://linked.open.../drugbank/synonym	Isosorbide dinitrate (en) Carvasin (en) Dinitrosorbide (en) Flindix (en) ISDN (en)

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