About: Flupentixol

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An Entity of Type : http://linked.opendata.cz/ontology/drugbank/Drug, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	http://linked.opendata.cz/ontology/drugbank/Drug
http://linked.open...gbank/description	Flupentixol is an antipsychotic neuroleptic drug. It is a thioxanthene, and therefore closely related to the phenothiazines. Its primary use is as a long acting injection given two or three weekly to people with schizophrenia who have a poor compliance with medication and suffer frequent relapses of illness. It is a D1 and D2 receptor antagonist. It is not approved in the United States. (en)
http://linked.open...gy/drugbank/group	approved (en) withdrawn (en)
http://linked.open...drugbank/halfLife	19 to 39 hours (en)
http://linked.open...ugbank/indication	For use in the treatment of schizophrenia and depression (en)
sameAs	Flupentixol Flupentixol
Title	Flupentixol (en)
adms:identifier	http://linked.opendata.cz/resource/drugbank/drug/DB00875/identifier/chebi/5121 http://linked.opendata.cz/resource/drugbank/drug/DB00875/identifier/drugbank/DB00875 http://linked.opendata.cz/resource/drugbank/drug/DB00875/identifier/guide-to-pharmacology/968 http://linked.opendata.cz/resource/drugbank/drug/DB00875/identifier/iuphar/968 http://linked.opendata.cz/resource/drugbank/drug/DB00875/identifier/kegg-drug/D01044 http://linked.opendata.cz/resource/drugbank/drug/DB00875/identifier/pharmgkb/PA10268 http://linked.opendata.cz/resource/drugbank/drug/DB00875/identifier/wikipedia/Flupenthixol
http://linked.open...mechanismOfAction	Flupenthixol is a thioxanthene antipsychotic. The mechanism of action of Flupenthixol is not completely understood. Flupenthixol is a powerful antagonist of both D1 and D2 dopamine receptors, and an alpha-adrenergic receptor antagonist. It's antipsychotic activity is thought to be related to blocks postsynaptic dopamine receptors in the CNS. (en)
http://linked.open.../drugbank/synonym	Flupentixol (en) Flupenthixol (en) Flupenthixole (en) Flupentixolo (en) Flupentixolum (en)
http://linked.open...drugbank/toxicity	LD<sub>50</sub>=300 mk/kg (Oral in mice); LD<sub>50</sub>=791 mg/kg (Oral in rats); LD<sub>50</sub>=87 mk/kg (IV in mice); LD<sub>50</sub>=37 mg/kg (IV in rats) (en)
http://linked.open...k/foodInteraction	Avoid alcohol. (en) Take with food to reduce irritation. (en)
http://linked.open.../drugbank/mixture	Anxiset Deanxit Frenxit Mixit Mocalm
http://linked.open...nk/proteinBinding	Highly bound to plasma proteins (>95%) (en)
http://linked.open...ogy/drugbank/salt	(en)
http://linked.open...ynthesisReference	Smith Kline & French Laboratories; British Patent 925,538; May 8, 1963. Craig, P.N. and Zirkle, C.L.; U.S. Patent 3,282,930; November 1, 1966; assigned to Smith Kline & French Laboratories. (en)
http://linked.open...y/mesh/hasConcept	http://linked.opendata.cz/resource/mesh/concept/M0008640
foaf:page	http://www.drugs.com/international/flupentixol.html
http://linked.open...ugbank/IUPAC-Name	http://linked.opendata.cz/resource/drugbank/property/271B5539-363D-11E5-9242-09173F13E4C5
http://linked.open...gy/drugbank/InChI	http://linked.opendata.cz/resource/drugbank/property/271B553F-363D-11E5-9242-09173F13E4C5
http://linked.open...Molecular-Formula	http://linked.opendata.cz/resource/drugbank/property/271B553E-363D-11E5-9242-09173F13E4C5
http://linked.open.../Molecular-Weight	http://linked.opendata.cz/resource/drugbank/property/271B553B-363D-11E5-9242-09173F13E4C5
http://linked.open...noisotopic-Weight	http://linked.opendata.cz/resource/drugbank/property/271B553C-363D-11E5-9242-09173F13E4C5
http://linked.open...y/drugbank/SMILES	http://linked.opendata.cz/resource/drugbank/property/271B553D-363D-11E5-9242-09173F13E4C5
http://linked.open.../Water-Solubility	http://linked.opendata.cz/resource/drugbank/property/271B554F-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/property/271B5537-363D-11E5-9242-09173F13E4C5
http://linked.open...ogy/drugbank/logP	http://linked.opendata.cz/resource/drugbank/property/271B5550-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/property/271B5535-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/property/271B5538-363D-11E5-9242-09173F13E4C5
http://linked.open...ogy/drugbank/logS	http://linked.opendata.cz/resource/drugbank/property/271B5536-363D-11E5-9242-09173F13E4C5
http://linked.open...l/drug/hasATCCode	Flupentixol
http://linked.open...nd-Acceptor-Count	http://linked.opendata.cz/resource/drugbank/property/271B5545-363D-11E5-9242-09173F13E4C5
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http://linked.open...nk/Polarizability	http://linked.opendata.cz/resource/drugbank/property/271B5543-363D-11E5-9242-09173F13E4C5
http://linked.open...bank/Refractivity	http://linked.opendata.cz/resource/drugbank/property/271B5542-363D-11E5-9242-09173F13E4C5
http://linked.open...atable-Bond-Count	http://linked.opendata.cz/resource/drugbank/property/271B5544-363D-11E5-9242-09173F13E4C5
http://linked.open...ugbank/absorption	Fairly slow and incomplete after oral administration (en)
http://linked.open.../affectedOrganism	Humans and other mammals (en)
http://linked.open...casRegistryNumber	2709-56-0 (en)
http://linked.open...drugbank/category	(en)
http://linked.open...gbank/containedIn	Fluanxol Depot 20 mg/ml Fluanxol Depot 100 mg/ml Fluanxol 0.5 mg Tablet Fluanxol 3 mg Tablet
http://linked.open...k/Bioavailability	http://linked.opendata.cz/resource/drugbank/property/271B554B-363D-11E5-9242-09173F13E4C5
http://linked.open...bank/Ghose-Filter	http://linked.opendata.cz/resource/drugbank/property/271B554D-363D-11E5-9242-09173F13E4C5
http://linked.open...nk/MDDR-Like-Rule	http://linked.opendata.cz/resource/drugbank/property/271B554E-363D-11E5-9242-09173F13E4C5
http://linked.open...k/Number-of-Rings	http://linked.opendata.cz/resource/drugbank/property/271B554A-363D-11E5-9242-09173F13E4C5
http://linked.open...siological-Charge	http://linked.opendata.cz/resource/drugbank/property/271B5549-363D-11E5-9242-09173F13E4C5
http://linked.open...bank/Rule-of-Five	http://linked.opendata.cz/resource/drugbank/property/271B554C-363D-11E5-9242-09173F13E4C5
http://linked.open...tional-IUPAC-Name	http://linked.opendata.cz/resource/drugbank/property/271B553A-363D-11E5-9242-09173F13E4C5
http://linked.open...strongest-acidic-	http://linked.opendata.cz/resource/drugbank/property/271B5547-363D-11E5-9242-09173F13E4C5
http://linked.open...-strongest-basic-	http://linked.opendata.cz/resource/drugbank/property/271B5548-363D-11E5-9242-09173F13E4C5

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