About: Dorzolamide

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About: Dorzolamide Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/drugbank/Drug, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
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http://linked.open...gbank/description	Dorzolamide is a carbonic anhydrase (CA) inhibitor. It is used in ophthalmic solutions (Trusopt) to lower intraocular pressure (IOP) in open-angle glaucoma and ocular hypertension. (en)
http://linked.open...y/drugbank/dosage	http://linked.opendata.cz/resource/drugbank/dosage/271B5311-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/dosage/271B5312-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/dosage/271B5313-363D-11E5-9242-09173F13E4C5
http://linked.open...generalReferences	# Plummer CE, MacKay EO, Gelatt KN: Comparison of the effects of topical administration of a fixed combination of dorzolamide-timolol to monotherapy with timolol or dorzolamide on IOP, pupil size, and heart rate in glaucomatous dogs. Vet Ophthalmol. 2006 Jul-Aug;9(4):245-9. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/16771760 # Grover S, Apushkin MA, Fishman GA: Topical dorzolamide for the treatment of cystoid macular edema in patients with retinitis pigmentosa. Am J Ophthalmol. 2006 May;141(5):850-8. Epub 2006 Mar 20. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/16546110 # Almeida GC Jr, Faria e Souza SJ: Effect of topical dorzolamide on rabbit central corneal thickness. Braz J Med Biol Res. 2006 Feb;39(2):277-81. Epub 2006 Feb 2. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/16470316 # Martens-Lobenhoffer J, Banditt P: Clinical pharmacokinetics of dorzolamide. Clin Pharmacokinet. 2002;41(3):197-205. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/11929320 # Balfour JA, Wilde MI: Dorzolamide. A review of its pharmacology and therapeutic potential in the management of glaucoma and ocular hypertension. Drugs Aging. 1997 May;10(5):384-403. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/9143858 # Ponticello GS, Sugrue MF, Plazonnet B, Durand-Cavagna G: Dorzolamide, a 40-year wait. From an oral to a topical carbonic anhydrase inhibitor for the treatment of glaucoma. Pharm Biotechnol. 1998;11:555-74. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/9760696 (en)
http://linked.open...gy/drugbank/group	approved (en)
http://linked.open...drugbank/halfLife	4 months (en)
http://linked.open...ugbank/indication	For the treatment of elevated intraocular pressure in patients with ocular hypertension or open-angle glaucoma. Also used prophylatically for the inhibition of perioperative IOP increase (before neodynium yttrium aluminum garnet laser posterior capsulotomy). (en)
http://linked.open...bank/manufacturer	A-S Medication Solutions LLC Apotex inc Bausch and lomb inc Cardinal Health Caremark LLC Comprehensive Consultant Services Inc. Corepharma LLC Direct Dispensing Inc.
sameAs	Dorzolamide Dorzolamide
Title	Dorzolamide (en)
adms:identifier	http://linked.opendata.cz/resource/drugbank/drug/DB00869/identifier/bindingdb/50043906 http://linked.opendata.cz/resource/drugbank/drug/DB00869/identifier/chebi/4702 http://linked.opendata.cz/resource/drugbank/drug/DB00869/identifier/drugbank/DB00869 http://linked.opendata.cz/resource/drugbank/drug/DB00869/identifier/kegg-compound/C06969 http://linked.opendata.cz/resource/drugbank/drug/DB00869/identifier/kegg-drug/D07871 http://linked.opendata.cz/resource/drugbank/drug/DB00869/identifier/national-drug-code-directory/0093-7618-33 http://linked.opendata.cz/resource/drugbank/drug/DB00869/identifier/pharmgkb/PA164748765 http://linked.opendata.cz/resource/drugbank/drug/DB00869/identifier/wikipedia/Dorzolamide
http://linked.open...mechanismOfAction	Dorzolamide is a sulfonamide and a highly specific carbonic anhydrase II (CA-II) inhibitor, which is the main CA isoenzyme involved in aqueous humor secretion. Inhibition of CA-II in the ciliary processes of the eye decreases aqueous humor secretion, presumably by slowing the formation of bicarbonate ions with subsequent reduction in sodium and fluid transport. Dorzolamide also accumulates in red blood cells as a result of CA-II binding, as CA-II is found predominantly in erythrocytes. However, sufficient CA-II activity remains so that adverse effects due to systemic CA inhibition are not observed. (en)
http://linked.open...drugbank/packager	Apotex Inc. Dispensing Solutions Falcon Pharmaceuticals Ltd. Hi Tech Pharmacal Co. Inc. Actavis Group Advanced Pharmaceutical Services Inc. Aidarex Pharmacuticals LLC Alphapharm Party Ltd. Sandoz Alcon Laboratories
http://linked.open...y/drugbank/patent	http://linked.opendata.cz/resource/drugbank/patent/1329211
http://linked.open...outeOfElimination	Dorzolamide is primarily excreted unchanged in the urine; the metabolite also is excreted in urine. (en)
http://linked.open.../drugbank/synonym	Dorzolamide (en) 4-Ethylamino-6-methyl-7,7-dioxo-4,5,6,7-tetrahydro-7lambda6-thieno[2,3-b]thiopyran-2-sulfonic acid amide (en) 4S,6S-Dorzolamide (en) (4S-trans)-4-(ETHYLAMINO)-5,6-dihydro-6-methyl-4H-thieno(2,3-b)thiopyran-2-sulfonamide-7,7-dioxide (en) Dorzolamid (en) Dorzolamida (en) Dorzolamidum (en) (4S,trans)-4-(Ethylamino)-6-methyl-5,6-dihydro-4H-thieno[2,3-b]thiopyran-2-sulfonamide 7,7-dioxide (en) (4S,6S)-4-Ethylamino-6-methyl-7,7-dioxo-4,5,6,7-tetrahydro-7lambda6-thieno[2,3-b]thiopyran-2-sulfonic acid amide (en) 4-Ethylamino-6-methyl-7,7-dioxo-4,5,6,7-tetrahydro-7lambda6-thieno[2,3-b]thiopyran-2-sulfonic acid amide (en)
http://linked.open...drugbank/toxicity	Dizziness, headache, shortness of breath, slow heartbeat, severe asthma, cardiac arrest (en)
http://linked.open.../drug/hasAHFSCode	http://linked.opendata.cz/resource/AHFS/52-10-00
http://linked.open.../drugbank/mixture	Cosopt
http://linked.open...nk/proteinBinding	~33% (en)
http://linked.open...ogy/drugbank/salt	(en)
http://linked.open...ynthesisReference	Laszlo Kovacs, Csaba Szabo, Erika Molnarne, Adrienne Kovacsne-Mezei, Claude Singer, Judith Aronhime, "Method of making dorzolamide hydrochloride." U.S. Patent US20060155132, issued July 13, 2006. (en)
foaf:page	http://www.drugs.com/cdi/dorzolamide-drops.html http://www.rxlist.com/cgi/generic/dorzolamide.htm
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http://linked.open.../affectedOrganism	Humans and other mammals (en)
http://linked.open...casRegistryNumber	120279-96-1 (en)
http://linked.open...gbank/containedIn	Solodyn er 65 mg tablet Solodyn er 90 mg tablet Solodyn 135 mg 24 Hour tablet Dorzolamide hcl 2% eye drops Dorzolamide HCl 2% Solution 10ml Bottle Solodyn 90 mg 24 Hour tablet
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