About: Diflunisal

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An Entity of Type : http://linked.opendata.cz/ontology/drugbank/Drug, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	http://linked.opendata.cz/ontology/drugbank/Drug
http://linked.open...gbank/description	Diflunisal, a salicylate derivative, is a nonsteroidal anti-inflammatory agent (NSAIA) with pharmacologic actions similar to other prototypical NSAIAs. Diflunisal possesses anti-inflammatory, analgesic and antipyretic activity. Though its mechanism of action has not been clearly established, most of its actions appear to be associated with inhibition of prostaglandin synthesis via the arachidonic acid pathway. Diflunisal is used to relieve pain accompanied with inflammation and in the symptomatic treatment of rheumatoid arthritis and osteoarthritis. (en)
http://linked.open...y/drugbank/dosage	http://linked.opendata.cz/resource/drugbank/dosage/271B508B-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/dosage/271B508C-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/dosage/271B508D-363D-11E5-9242-09173F13E4C5
http://linked.open...gy/drugbank/group	approved (en)
http://linked.open...drugbank/halfLife	8 to 12 hours (en)
http://linked.open...ugbank/indication	For symptomatic treatment of mild to moderate pain accompanied by inflammation (e.g. musculoskeletal trauma, post-dental extraction, post-episiotomy), osteoarthritis, and rheumatoid arthritis. (en)
http://linked.open...bank/manufacturer	App pharmaceuticals llc Bioniche pharma usa llc Hospira inc Perrigo Co. Banner pharmacaps inc Abbott laboratories pharmaceutical products div
sameAs	Diflunisal Diflunisal
Title	Diflunisal (en)
adms:identifier	http://linked.opendata.cz/resource/drugbank/drug/DB00861/identifier/chebi/39669 http://linked.opendata.cz/resource/drugbank/drug/DB00861/identifier/chemspider/2951 http://linked.opendata.cz/resource/drugbank/drug/DB00861/identifier/drugbank/DB00861 http://linked.opendata.cz/resource/drugbank/drug/DB00861/identifier/kegg-compound/C01691 http://linked.opendata.cz/resource/drugbank/drug/DB00861/identifier/kegg-drug/D00130 http://linked.opendata.cz/resource/drugbank/drug/DB00861/identifier/national-drug-code-directory/54868-3049-3 http://linked.opendata.cz/resource/drugbank/drug/DB00861/identifier/pdb/FHI http://linked.opendata.cz/resource/drugbank/drug/DB00861/identifier/pharmgkb/PA449313 http://linked.opendata.cz/resource/drugbank/drug/DB00861/identifier/pubchem-compound/3059 http://linked.opendata.cz/resource/drugbank/drug/DB00861/identifier/pubchem-substance/46507807 http://linked.opendata.cz/resource/drugbank/drug/DB00861/identifier/wikipedia/Diflunisal
http://linked.open...mechanismOfAction	The precise mechanism of the analgesic and anti-inflammatory actions of diflunisal is not known. Diflunisal is a prostaglandin synthetase inhibitor. In animals, prostaglandins sensitize afferent nerves and potentiate the action of bradykinin in inducing pain. Since prostaglandins are known to be among the mediators of pain and inflammation, the mode of action of diflunisal may be due to a decrease of prostaglandins in peripheral tissues. (en)
http://linked.open...drugbank/packager	A-S Medication Solutions LLC Dispensing Solutions Diversified Healthcare Services Inc. Endo Pharmaceuticals Inc. Pharmaceutical Utilization Management Program VA Inc. Lake Erie Medical and Surgical Supply Major Pharmaceuticals Murfreesboro Pharmaceutical Nursing Supply Sandoz PD-Rx Pharmaceuticals Inc. Dispensing Solutions Apotex Inc. A-S Medication Solutions LLC Baxter International Inc. Sandoz E. Fougera and Co. G & W Labs GlaxoSmithKline Inc. Sandoz Letco Medical Inc.
http://linked.open...outeOfElimination	The drug is excreted in the urine as two soluble glucuronide conjugates accounting for about 90% of the administered dose. Little or no diflunisal is excreted in the feces. (en)
http://linked.open.../drugbank/synonym	Diflunisal (en) Dolobid (en) 2',4'-Difluoro-4-hydroxy-3-biphenylcarboxylic acid (en) 2-(Hydroxy)-5-(2,4-difluorophenyl)benzoic acid (en) 5-(2,4-Difluorophenyl)salicylic acid (en) Diflunisalum (en)
http://linked.open...drugbank/toxicity	Oral LD<sub>50</sub> in rat, mouse, and rabbit is 392 mg/kg, 439 mg/kg, and 603 mg/kg, respectively. Symptoms of overdose include drowsiness, nausea, vomiting, diarrhea, hyperventilation, tachycardia, sweating, tinnitus, disorientation, stupor, and coma. The lowest dose without the presence of other medicines which caused death was 15 grams. <p>Selective COX-2 inhibitors have been associated with increased risk of serious cardiovascular events (e.g. myocardial infarction, stroke) in some patients. Current data is insufficient to assess the cardiovascular risk of diflunisal. Short-term use does not appear to be associated with increased cardiovascular risk (except when used immediately following coronary artery bypass graft (CABG) surgery). Risk of GI toxicity including bleeding, ulceration and perforation. Risk of direct renal injury, including renal papillary necrosis. Severe hepatic reactions, including cholestasis and/or jaundice, have been reported. May cause rash or hypersensitivity syndrome.</p> (en)
http://linked.open.../drug/hasAHFSCode	http://linked.opendata.cz/resource/AHFS/28-08-04-92
http://linked.open...k/foodInteraction	Avoid alcohol. (en) Take with food to reduce gastric irritation. (en) Food slightly delays rate of absorption with no effect on extent of absorption. (en)
http://linked.open...nk/proteinBinding	At least 98 to 99% of diflunisal in plasma is bound to proteins. (en)
http://linked.open...ynthesisReference	Ruyle, W.V., Jarett, L.H. and Matzuk, A.R. ; U S . Patent 3,714,226; January 30, 1973; assigned to Merck & Co., Inc. (en)
foaf:page	http://www.drugs.com/cdi/diflunisal.html http://www.pdrhealth.com/drug_info/rxdrugprofiles/drugs/dol1145.shtml http://www.rxlist.com/cgi/generic3/diflunisal.htm
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http://linked.open.../Molecular-Weight	http://linked.opendata.cz/resource/drugbank/property/271B5094-363D-11E5-9242-09173F13E4C5
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http://linked.open...l/drug/hasATCCode	Diflunisal
http://linked.open...nd-Acceptor-Count	http://linked.opendata.cz/resource/drugbank/property/271B509E-363D-11E5-9242-09173F13E4C5
http://linked.open...-Bond-Donor-Count	http://linked.opendata.cz/resource/drugbank/property/271B509F-363D-11E5-9242-09173F13E4C5
http://linked.open...drugbank/InChIKey	http://linked.opendata.cz/resource/drugbank/property/271B5099-363D-11E5-9242-09173F13E4C5
http://linked.open...urface-Area--PSA-	http://linked.opendata.cz/resource/drugbank/property/271B509A-363D-11E5-9242-09173F13E4C5
http://linked.open...nk/Polarizability	http://linked.opendata.cz/resource/drugbank/property/271B509C-363D-11E5-9242-09173F13E4C5
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http://linked.open...atable-Bond-Count	http://linked.opendata.cz/resource/drugbank/property/271B509D-363D-11E5-9242-09173F13E4C5
http://linked.open...ugbank/absorption	Rapidly and completely absorbed following oral administration, with a bioavailability of 80-90%. Peak plasma concentrations are achieved 2 - 3 hours following oral administration. (en)
http://linked.open.../affectedOrganism	Humans and other mammals (en)
http://linked.open...casRegistryNumber	22494-42-4 (en)
http://linked.open...drugbank/category	(en)
http://linked.open...gbank/containedIn	Diflunisal 500 mg tablet Apo-Keto 50 mg Capsule Apo-Keto-E 50 mg Enteric-Coated Tablet Apo-Keto-E 100 mg Enteric-Coated Tablet Apo-Diflunisal 500 mg Tablet
http://linked.open...k/Bioavailability	http://linked.opendata.cz/resource/drugbank/property/271B50A4-363D-11E5-9242-09173F13E4C5
http://linked.open...bank/Ghose-Filter	http://linked.opendata.cz/resource/drugbank/property/271B50A6-363D-11E5-9242-09173F13E4C5
http://linked.open...nk/MDDR-Like-Rule	http://linked.opendata.cz/resource/drugbank/property/271B50A7-363D-11E5-9242-09173F13E4C5
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http://linked.open...k/Number-of-Rings	http://linked.opendata.cz/resource/drugbank/property/271B50A3-363D-11E5-9242-09173F13E4C5

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