About: Perphenazine     Goto   Sponge   NotDistinct   Permalink

An Entity of Type : http://linked.opendata.cz/ontology/drugbank/Drug, within Data Space : linked.opendata.cz associated with source document(s)

AttributesValues
rdf:type
http://linked.open...gbank/description
  • An antipsychotic phenothiazine derivative with actions and uses similar to those of chlorpromazine. [PubChem] (en)
http://linked.open...y/drugbank/dosage
http://linked.open...gy/drugbank/group
  • approved (en)
http://linked.open...drugbank/halfLife
  • 8-12 hours, but ranges up to 20 hours. (en)
http://linked.open...ugbank/indication
  • For use in the management of the manifestations of psychotic disorders and for the control of severe nausea and vomiting in adults. (en)
http://linked.open...bank/manufacturer
sameAs
Title
  • Perphenazine (en)
adms:identifier
http://linked.open...mechanismOfAction
  • Binds to the dopamine D1 and dopamine D2 receptors and inhibits their activity. The mechanism of the anti-emetic effect is due predominantly to blockage of the dopamine D2 neurotransmitter receptors in the chemoreceptor trigger zone and vomiting centre. Perphenazine also binds the alpha andrenergic receptor. This receptor's action is mediated by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. (en)
http://linked.open...drugbank/packager
http://linked.open...outeOfElimination
  • Perphenazine is extensively metabolized in the liver to a number of metabolites by sulfoxidation, hydroxylation, dealkylation, and glucuronidation. (en)
http://linked.open.../drugbank/synonym
  • Trilafon (en)
  • Etaperazin (en)
  • Etaperazine (en)
  • Ethaperazine (en)
  • Perfenazina (en)
  • Perfenazine (en)
  • Perphenazin (en)
  • Chlorpiprazine (en)
  • 2-(4-[3-(2-chloro-10H-Phenothiazin-10-yl)propyl]-1-piperazinyl)ethanol (en)
  • Perphenazinum (en)
  • Perphénazine (en)
  • 4-[3-(2-Chlorophenothiazin-10-yl)propyl]-1-piperazineethanol (en)
  • 4-[3-(2-chloro-10H-Phenothiazin-10-yl)propyl]-1-piperazineethanol (en)
  • gamma-(4-(beta-Hydroxyethyl)piperazin-1-yl)propyl-2-chlorophenothiazine (en)
  • 2-chloro-10-(3-(4-(2-Hydroxyethyl)piperazin-1-yl)propyl)phenothiazine (en)
http://linked.open...drugbank/toxicity
  • Symptoms of overdose include stupor or coma, and children may have convulsive seizures. Signs of arousal may not occur for 48 hours. Oral LD<sub>50</sub>=318 mg/kg (rat); IPR LD<sub>50</sub>=64 mg/kg (mouse) (en)
http://linked.open.../drug/hasAHFSCode
http://linked.open...k/foodInteraction
  • Do not take calcium, aluminum, magnesium or Iron supplements within 2 hours of taking this medication. (en)
  • Avoid alcohol. (en)
  • Take with food. (en)
http://linked.open.../drugbank/mixture
http://linked.open...ogy/drugbank/salt
  • (en)
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