About: Tolazamide     Goto   Sponge   NotDistinct   Permalink

An Entity of Type : http://linked.opendata.cz/ontology/drugbank/Drug, within Data Space : linked.opendata.cz associated with source document(s)

AttributesValues
rdf:type
http://linked.open...gbank/description
  • A sulphonylurea hypoglycemic agent with actions and uses similar to those of chlorpropamide. [PubChem] (en)
http://linked.open...y/drugbank/dosage
http://linked.open...gy/drugbank/group
  • approved (en)
http://linked.open...drugbank/halfLife
  • The average biological half-life of the drug is 7 hours. (en)
http://linked.open...ugbank/indication
  • For use as an adjunct to diet to lower the blood glucose in patients with non-insulin dependent diabetes mellitus (Type II) whose hyperglycemia cannot be satisfactorily controlled by diet alone. (en)
http://linked.open...bank/manufacturer
sameAs
Title
  • Tolazamide (en)
adms:identifier
http://linked.open...mechanismOfAction
  • Sulfonylureas likely bind to ATP-sensitive potassium-channel receptors on the pancreatic cell surface, reducing potassium conductance and causing depolarization of the membrane. Depolarization stimulates calcium ion influx through voltage-sensitive calcium channels, raising intracellular concentrations of calcium ions, which induces the secretion, or exocytosis, of insulin. (en)
http://linked.open...drugbank/packager
http://linked.open...outeOfElimination
  • Tolazamide is metabolized to five major metabolites ranging in hypoglycemic activity from 0% to 70%. They are excreted principally in the urine. (en)
http://linked.open.../drugbank/synonym
  • Tolazamide (en)
  • Norglycin (en)
  • Tolinase (en)
  • N-{[(hexahydro-1H-azepin-1-yl)-amino]carbonyl}-4-methylbenzenesulfonamide (en)
  • 1-(hexahydro-1-Azepinyl)-3-P-tolylsulfonylurea (en)
  • 4-(P-Tolylsulfonyl)-1,1-hexamethylenesemicarbazide (en)
  • BRN 1323565 (en)
  • CCRIS 591 (en)
  • Diabewas (en)
  • EINECS 214-588-3 (en)
  • N-(P-Toluenesulfonyl)-n'-hexamethyleniminourea (en)
  • Tolazamid (en)
  • Tolazamida (en)
  • Tolazamidum (en)
  • U 17835 (en)
  • U-17835 (en)
  • 1-(hexahydro-1H-Azepin-1-yl)-3-(P-tolylsulfonyl)urea (en)
http://linked.open...drugbank/toxicity
  • Overdosage of sulfonylureas can produce hypoglycemia. Severe hypoglycemic reactions with coma, seizure, or other neurological impairment occur infrequently, but constitute medical emergencies requiring immediate hospitalization. (en)
foaf:page
http://linked.open...ugbank/IUPAC-Name
http://linked.open...gy/drugbank/InChI
http://linked.open...Molecular-Formula
http://linked.open.../Molecular-Weight
http://linked.open...noisotopic-Weight
http://linked.open...y/drugbank/SMILES
http://linked.open.../Water-Solubility
http://linked.open...ogy/drugbank/logP
http://linked.open...ogy/drugbank/logS
http://linked.open...l/drug/hasATCCode
http://linked.open...nd-Acceptor-Count
http://linked.open...-Bond-Donor-Count
http://linked.open...drugbank/InChIKey
http://linked.open...urface-Area--PSA-
http://linked.open...nk/Polarizability
http://linked.open...bank/Refractivity
http://linked.open...atable-Bond-Count
http://linked.open...ugbank/absorption
  • Rapidly and well absorbed from the gastrointestinal tract. (en)
http://linked.open.../affectedOrganism
  • Humans and other mammals (en)
http://linked.open...casRegistryNumber
  • 1156-19-0 (en)
http://linked.open...gbank/containedIn
http://linked.open...k/Bioavailability
http://linked.open...bank/Ghose-Filter
http://linked.open...nk/MDDR-Like-Rule
http://linked.open...ank/Melting-Point
http://linked.open...k/Number-of-Rings
http://linked.open...siological-Charge
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