About: Phenylbutazone     Goto   Sponge   NotDistinct   Permalink

An Entity of Type : http://linked.opendata.cz/ontology/drugbank/Drug, within Data Space : linked.opendata.cz associated with source document(s)

AttributesValues
rdf:type
http://linked.open...gbank/description
  • A drug that has anti-inflammatory, antipyretic, and analgesic activities. It is especially effective in the treatment of ankylosing spondylitis. It also is useful in rheumatoid arthritis and Reiter's syndrome (investigational indication). Although phenylbutazone is effective in gouty arthritis, risk/benefit considerations indicate that this drug should not be employed for this disease. (From AMA Drug Evaluations Annual, 1994, p1822) (en)
http://linked.open...gy/drugbank/group
  • approved (en)
http://linked.open...ugbank/indication
  • For the treatment of backache and ankylosing spondylitis (en)
http://linked.open...bank/manufacturer
sameAs
Title
  • Phenylbutazone (en)
adms:identifier
http://linked.open...mechanismOfAction
  • Phenylbutazone binds to and inactivates prostaglandin H synthase and prostacyclin synthase through peroxide (H2O2) mediated deactivation. The reduced production of prostaglandin leads to reduced inflammation of the surrounding tissues. (en)
http://linked.open...drugbank/packager
http://linked.open.../drugbank/synonym
  • Phenylbutazone (en)
  • Fenilbutazona (en)
  • Phenbutazone (en)
  • Phenylbutazonum (en)
  • 3,5-Dioxo-1,2-diphenyl-4-n-butylpyrazolidine (en)
  • 4-BUTYL-1,2-diphenyl-pyrazolidine-3,5-dione (en)
  • 4-n-Butyl-1,2-diphenyl-3,5-pyrazolidinedione (en)
  • Phenylbutazon (en)
http://linked.open...drugbank/toxicity
  • Oral, LD<sub>50</sub> = 238 mg/kg (mouse); Oral, LD<sub>50</sub> = 781 mg/kg (rabbit); Oral, LD<sub>50</sub> = 245 mg/kg (rat); Oral, LD<sub>50</sub> = 375 mg/kg (rat) (en)
http://linked.open.../drug/hasAHFSCode
http://linked.open...k/foodInteraction
  • Take with food to reduce irritation. Avoid alcohol. (en)
http://linked.open.../drugbank/mixture
http://linked.open...ynthesisReference
  • Dieter Rahtz, Henning Koch, Erich Gerhards, "Hydroxy phenylbutazone derivatives and their preparation." U.S. Patent US3968219, issued January, 1971. (en)
http://linked.open...ugbank/IUPAC-Name
http://linked.open...gy/drugbank/InChI
http://linked.open...Molecular-Formula
http://linked.open.../Molecular-Weight
http://linked.open...noisotopic-Weight
http://linked.open...y/drugbank/SMILES
http://linked.open.../Water-Solubility
http://linked.open...ogy/drugbank/logP
http://linked.open...ogy/drugbank/logS
http://linked.open...logy/drugbank/pKa
http://linked.open...l/drug/hasATCCode
http://linked.open...nd-Acceptor-Count
http://linked.open...-Bond-Donor-Count
http://linked.open...drugbank/InChIKey
http://linked.open...urface-Area--PSA-
http://linked.open...nk/Polarizability
http://linked.open...bank/Refractivity
http://linked.open...atable-Bond-Count
http://linked.open.../affectedOrganism
  • Humans and other mammals (en)
http://linked.open...casRegistryNumber
  • 50-33-9 (en)
http://linked.open...drugbank/category
  • (en)
http://linked.open...gbank/containedIn
http://linked.open...k/Bioavailability
http://linked.open...bank/Ghose-Filter
http://linked.open...nk/MDDR-Like-Rule
http://linked.open...ank/Melting-Point
http://linked.open...k/Number-of-Rings
http://linked.open...siological-Charge
http://linked.open...bank/Rule-of-Five
http://linked.open...tional-IUPAC-Name
http://linked.open...strongest-acidic-
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