About: Proparacaine

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An Entity of Type : http://linked.opendata.cz/ontology/drugbank/Drug, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	http://linked.opendata.cz/ontology/drugbank/Drug
http://linked.open...gbank/description	Proparacaine is a topical anesthetic drug of the amino ester group. It is available as its hydrochloride salt in ophthalmic solutions at a concentration of 0.5%. [Wikipedia] (en)
http://linked.open...y/drugbank/dosage	http://linked.opendata.cz/resource/drugbank/dosage/271B403F-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/dosage/271B4040-363D-11E5-9242-09173F13E4C5
http://linked.open...gy/drugbank/group	approved (en)
http://linked.open...ugbank/indication	Used as a local (ophthalmic) anesthetic. (en)
http://linked.open...bank/manufacturer	Amgen Inc. Bausch and lomb pharmaceuticals inc Pharmaceutical Utilization Management Program VA Inc. Pharmaceutics International Inc. Apothecon inc div bristol myers squibb Allergan pharmaceutical Prepackage Specialists QPharm Inc.
sameAs	Proparacaine Proparacaine
Title	Proparacaine (en)
adms:identifier	http://linked.opendata.cz/resource/drugbank/drug/DB00807/identifier/bindingdb/50017718 http://linked.opendata.cz/resource/drugbank/drug/DB00807/identifier/chemspider/4766 http://linked.opendata.cz/resource/drugbank/drug/DB00807/identifier/drugbank/DB00807 http://linked.opendata.cz/resource/drugbank/drug/DB00807/identifier/kegg-compound/C07383 http://linked.opendata.cz/resource/drugbank/drug/DB00807/identifier/national-drug-code-directory/17478-263-12 http://linked.opendata.cz/resource/drugbank/drug/DB00807/identifier/pubchem-compound/4935 http://linked.opendata.cz/resource/drugbank/drug/DB00807/identifier/pubchem-substance/46507960 http://linked.opendata.cz/resource/drugbank/drug/DB00807/identifier/kegg-drug/D08448 http://linked.opendata.cz/resource/drugbank/drug/DB00807/identifier/pharmgkb/PA164776849 http://linked.opendata.cz/resource/drugbank/drug/DB00807/identifier/wikipedia/Proparacaine
http://linked.open...mechanismOfAction	The exact mechanism whereby proparacaine and other local anesthetics influence the permeability of the cell membrane is unknown; however, several studies indicate that local anesthetics may limit sodium ion permeability through the lipid layer of the nerve cell membrane. Proparacaine may alter epithelial sodium channels through interaction with channel protein residues. This limitation prevents the fundamental change necessary for the generation of the action potential. (en)
http://linked.open...drugbank/packager	Accutome Inc. Akorn Inc. Alcon Laboratories Allergan Inc. Innovative Manufacturing and Distribution Services Inc. A-S Medication Solutions LLC Bausch & Lomb Inc. Conta Care Ophthalmics and Diagnostics Deca Pharmaceuticals LLC Diversified Healthcare Services Inc. Eye Care and Cure Corp. Eye Supply Usa Inc. Falcon Pharmaceuticals Ltd. Medical Ophthalmics MWI Veterinary Supply Co. Abbott Laboratories Ltd. Apotheca Inc. A-S Medication Solutions LLC Orion Corporation Bryant Ranch Prepack Dispensing Solutions PD-Rx Pharmaceuticals Inc. Organon usa inc
http://linked.open.../drugbank/synonym	Proxymetacaine (en) Proparacaine (en) Proximetacaina (en) Proxymetacainum (en)
http://linked.open...ogy/drugbank/salt	(en)
http://linked.open...y/mesh/hasConcept	http://linked.opendata.cz/resource/mesh/concept/M0047456
foaf:page	http://www.drugs.com/cdi/proparacaine-drops.html http://www.rxlist.com/cgi/generic2/propara.htm
http://linked.open...ugbank/IUPAC-Name	http://linked.opendata.cz/resource/drugbank/property/271B4045-363D-11E5-9242-09173F13E4C5
http://linked.open...gy/drugbank/InChI	http://linked.opendata.cz/resource/drugbank/property/271B404B-363D-11E5-9242-09173F13E4C5
http://linked.open...Molecular-Formula	http://linked.opendata.cz/resource/drugbank/property/271B404A-363D-11E5-9242-09173F13E4C5
http://linked.open.../Molecular-Weight	http://linked.opendata.cz/resource/drugbank/property/271B4047-363D-11E5-9242-09173F13E4C5
http://linked.open...noisotopic-Weight	http://linked.opendata.cz/resource/drugbank/property/271B4048-363D-11E5-9242-09173F13E4C5
http://linked.open...y/drugbank/SMILES	http://linked.opendata.cz/resource/drugbank/property/271B4049-363D-11E5-9242-09173F13E4C5
http://linked.open.../Water-Solubility	http://linked.opendata.cz/resource/drugbank/property/271B4043-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/property/271B405A-363D-11E5-9242-09173F13E4C5
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http://linked.open...ogy/drugbank/logS	http://linked.opendata.cz/resource/drugbank/property/271B4042-363D-11E5-9242-09173F13E4C5
http://linked.open...logy/drugbank/pKa	http://linked.opendata.cz/resource/drugbank/property/271B405D-363D-11E5-9242-09173F13E4C5
http://linked.open...l/drug/hasATCCode	Proxymetacaine
http://linked.open...nd-Acceptor-Count	http://linked.opendata.cz/resource/drugbank/property/271B4051-363D-11E5-9242-09173F13E4C5
http://linked.open...-Bond-Donor-Count	http://linked.opendata.cz/resource/drugbank/property/271B4052-363D-11E5-9242-09173F13E4C5
http://linked.open...drugbank/InChIKey	http://linked.opendata.cz/resource/drugbank/property/271B404C-363D-11E5-9242-09173F13E4C5
http://linked.open...urface-Area--PSA-	http://linked.opendata.cz/resource/drugbank/property/271B404D-363D-11E5-9242-09173F13E4C5
http://linked.open...nk/Polarizability	http://linked.opendata.cz/resource/drugbank/property/271B404F-363D-11E5-9242-09173F13E4C5
http://linked.open...bank/Refractivity	http://linked.opendata.cz/resource/drugbank/property/271B404E-363D-11E5-9242-09173F13E4C5
http://linked.open...atable-Bond-Count	http://linked.opendata.cz/resource/drugbank/property/271B4050-363D-11E5-9242-09173F13E4C5
http://linked.open.../affectedOrganism	Humans and other mammals (en)
http://linked.open...casRegistryNumber	499-67-2 (en)
http://linked.open...drugbank/category	(en)
http://linked.open...gbank/containedIn	Adoxa 75 mg tablet Monodox 100 mg capsule Adoxa 100 mg tablet Doxycycline hyc 100 mg vial Doryx dr 150 mg tablet Alcaine 0.5 % Solution
http://linked.open...k/Bioavailability	http://linked.opendata.cz/resource/drugbank/property/271B4056-363D-11E5-9242-09173F13E4C5
http://linked.open...bank/Ghose-Filter	http://linked.opendata.cz/resource/drugbank/property/271B4058-363D-11E5-9242-09173F13E4C5
http://linked.open...nk/MDDR-Like-Rule	http://linked.opendata.cz/resource/drugbank/property/271B4059-363D-11E5-9242-09173F13E4C5
http://linked.open...ank/Melting-Point	http://linked.opendata.cz/resource/drugbank/property/271B405B-363D-11E5-9242-09173F13E4C5
http://linked.open...k/Number-of-Rings	http://linked.opendata.cz/resource/drugbank/property/271B4055-363D-11E5-9242-09173F13E4C5
http://linked.open...siological-Charge	http://linked.opendata.cz/resource/drugbank/property/271B4054-363D-11E5-9242-09173F13E4C5
http://linked.open...bank/Rule-of-Five	http://linked.opendata.cz/resource/drugbank/property/271B4057-363D-11E5-9242-09173F13E4C5
http://linked.open...tional-IUPAC-Name	http://linked.opendata.cz/resource/drugbank/property/271B4046-363D-11E5-9242-09173F13E4C5
http://linked.open...-strongest-basic-	http://linked.opendata.cz/resource/drugbank/property/271B4053-363D-11E5-9242-09173F13E4C5

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