About: Pentoxifylline     Goto   Sponge   NotDistinct   Permalink

An Entity of Type : http://linked.opendata.cz/ontology/drugbank/Drug, within Data Space : linked.opendata.cz associated with source document(s)

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http://linked.open...gbank/description
  • A methylxanthine derivative that inhibits phosphodiesterase and affects blood rheology. It improves blood flow by increasing erythrocyte and leukocyte flexibility. It also inhibits platelet aggregation. Pentoxifylline modulates immunologic activity by stimulating cytokine production. [PubChem] (en)
http://linked.open...y/drugbank/dosage
http://linked.open...generalReferences
  • # : European Pentoxifylline Multi-Infarct Dementia Study. Eur Neurol. 1996;36(5):315-21. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/8864715 (en)
http://linked.open...gy/drugbank/group
  • approved (en)
  • investigational (en)
http://linked.open...drugbank/halfLife
  • 0.4-0.8 hours (en)
http://linked.open...ugbank/indication
  • For the treatment of patients with intermittent lameness or immobility arising from chronic occlusive arterial disease of the limbs. (en)
http://linked.open...bank/manufacturer
sameAs
Title
  • Pentoxifylline (en)
adms:identifier
http://linked.open...mechanismOfAction
  • Pentoxifylline inhibits erythrocyte phosphodiesterase, resulting in an increase in erythrocyte cAMP activity. Subsequently, the erythrocyte membrane becomes more resistant to deformity. Along with erythrocyte activity, pentoxifylline also decreases blood viscosity by reducing plasma fibrinogen concentrations and increasing fibrinolytic activity. It is also a non selective adenosine receptor antagonist. (en)
http://linked.open...drugbank/packager
http://linked.open...outeOfElimination
  • Excretion is almost totally urinary; the main biotransformation product is Metabolite V. Essentially no parent drug is found in the urine. (en)
http://linked.open.../drugbank/synonym
  • Pentoxifylline (en)
  • Oxpentifylline (en)
  • Pentoxifyllin (en)
  • Pentoxil (en)
  • Trental (en)
  • Pentoxifilina (en)
  • Pentoxifyllinum (en)
http://linked.open...drugbank/toxicity
  • LD<sub>50</sub>=1385 mg/kg(orally in mice) (en)
http://linked.open.../drug/hasAHFSCode
http://linked.open...k/foodInteraction
  • Take with food to reduce irritation. Limit caffeine intake. (en)
http://linked.open.../drugbank/mixture
http://linked.open...nk/proteinBinding
  • 70% (en)
http://linked.open...y/mesh/hasConcept
foaf:page
http://linked.open...ugbank/IUPAC-Name
http://linked.open...gy/drugbank/InChI
http://linked.open...Molecular-Formula
http://linked.open.../Molecular-Weight
http://linked.open...noisotopic-Weight
http://linked.open...y/drugbank/SMILES
http://linked.open.../Water-Solubility
http://linked.open...ogy/drugbank/logP
http://linked.open...ogy/drugbank/logS
http://linked.open...l/drug/hasATCCode
http://linked.open...nd-Acceptor-Count
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