| Attributes | Values |
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| rdf:type
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| http://linked.open...gbank/description
| - Polymyxin B sulfate is a mixture of polymyxins B1 and B2, obtained from Bacillus polymyxa strains. They are basic polypeptides of about eight amino acids and have cationic detergent action on cell membranes. Polymyxin B is used for infections with gram-negative organisms, but may be neurotoxic and nephrotoxic. All gram-positive bacteria, fungi, and the gram-negative cocci, N. gonorrhea and N. menigitidis, are resistant. It is appropriate for treatment of infections of the urinary tract, meninges, and blood stream, caused by susceptible strains of Pseudomonas aeruginosa. (en)
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| http://linked.open...y/drugbank/dosage
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| http://linked.open...generalReferences
| - # Yuan Z, Tam VH: Polymyxin B: a new strategy for multidrug-resistant Gram-negative organisms. Expert Opin Investig Drugs. 2008 May;17(5):661-8. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/18447592 # Zavascki AP, Goldani LZ, Li J, Nation RL: Polymyxin B for the treatment of multidrug-resistant pathogens: a critical review. J Antimicrob Chemother. 2007 Dec;60(6):1206-15. Epub 2007 Sep 17. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/17878146 (en)
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| http://linked.open...gy/drugbank/group
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| http://linked.open...ugbank/indication
| - For treatment of infections of the urinary tract, meninges, and blood stream, caused by susceptible strains of <i>Pseudomonas aeruginosa</i>. (en)
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| http://linked.open...bank/manufacturer
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| sameAs
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| Title
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| adms:identifier
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| http://linked.open...mechanismOfAction
| - Polymyxin B sulfate has a bactericidal action against almost all gram-negative bacilli except the Proteus group. Polymyxin B sulfate interacts with the lipopolysaccharide of the cytoplasmic outer membrane of Gram-negative bacteria, altering membrane permeability and causing cell death. It does not need to enter the cell. (en)
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| http://linked.open...drugbank/packager
| |
| http://linked.open...outeOfElimination
| - The drug is excreted slowly by the kidneys. (en)
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| http://linked.open.../drugbank/synonym
| - Polimixina B (en)
- Polymyxin B (en)
- Polymyxin-B-Sulfat (en)
- Polymyxine B (en)
- Polymyxine B (sulfate de) (en)
- Polymyxini B sulfas (en)
- Polymyxinum B (en)
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| http://linked.open...drugbank/toxicity
| - Overdose can cause stomach pains, vomiting, and diarrhea. (en)
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| http://linked.open.../drugbank/mixture
| |
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