About: Imiquimod     Goto   Sponge   NotDistinct   Permalink

An Entity of Type : http://linked.opendata.cz/ontology/drugbank/Drug, within Data Space : linked.opendata.cz associated with source document(s)

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http://linked.open...gbank/description
  • Imiquimod is an immune response modifier that acts as a toll-like receptor 7 agonist. Imiquimod is commonly used topically to treat warts on the skin of the genital and anal areas. Imiquimod does not cure warts, and new warts may appear during treatment. Imiquimod does not fight the viruses that cause warts directly, however, it does help to relieve and control wart production. Miquimod is also used to treat a skin condition of the face and scalp called actinic keratoses and certain types of skin cancer called superficial basal cell carcinoma. (en)
http://linked.open...y/drugbank/dosage
http://linked.open...generalReferences
  • # "Link":http://www.3m.com/us/healthcare/pharma/aldara/con_overview.jhtml # van Egmond S, Hoedemaker C, Sinclair R: Successful treatment of perianal Bowen's disease with imiquimod. Int J Dermatol. 2007 Mar;46(3):318-9. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/17343595 # Hemmi H, Kaisho T, Takeuchi O, Sato S, Sanjo H, Hoshino K, Horiuchi T, Tomizawa H, Takeda K, Akira S: Small anti-viral compounds activate immune cells via the TLR7 MyD88-dependent signaling pathway. Nat Immunol. 2002 Feb;3(2):196-200. Epub 2002 Jan 22. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/11812998 # Bilu D, Sauder DN: Imiquimod: modes of action. Br J Dermatol. 2003 Nov;149 Suppl 66:5-8. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/14616337 # Miller RL, Gerster JF, Owens ML, Slade HB, Tomai MA: Imiquimod applied topically: a novel immune response modifier and new class of drug. Int J Immunopharmacol. 1999 Jan;21(1):1-14. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/10411278 (en)
http://linked.open...gy/drugbank/group
  • approved (en)
  • investigational (en)
http://linked.open...drugbank/halfLife
  • 20 hours (topical dose), 2 hours (subcutaneous dose) (en)
http://linked.open...ugbank/indication
  • For the topical treatment of clinically typical, nonhyperkeratotic, nonhypertrophic actinic keratoses on the face or scalp in immunocompetent adults. Also indicated for the treatment of external genital and perianal warts/condyloma acuminata in individuals 12 years old and above. (en)
http://linked.open...bank/manufacturer
sameAs
Title
  • Imiquimod (en)
adms:identifier
http://linked.open...mechanismOfAction
  • Imiquimod's mechanism of action is via stimulation of innate and acquired immune responses, which ultimately leads to inflammatory cell infiltration within the field of drug application followed by apoptosis of diseased tissue. Imiquimod does not have direct antiviral activity. Studies of mice show that imiquimod may induce cytokines, including interferon-alpha (IFNA) as well as several IFNA genes (IFNA1, IFNA2, IFNA5, IFNA6, and IFNA8) as well as the IFNB gene. Imiquimod also induced the expression of interleukin (IL)-6, IL-8, and tumor necrosis factor alpha genes. In the treatment of basal cell carcinoma, Imiquimod appears to act as a toll-like receptor-7 agonist, and is thought to exert its anti-tumor effect via modification of the immune response and stimulation of apoptosis in BCC cells. In treating basal cell carcinoma it may increase the infiltration of lymphocytes, dendritic cells, and macrophages into the tumor lesion. (en)
http://linked.open...drugbank/packager
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http://linked.open.../drugbank/synonym
  • Imiquimod (en)
  • 1-Isobutyl-1H-imidazo[4,5-c]quinolin-4-amine (en)
  • 4-Amino-1-isobutyl-1H-imidazo(4,5-c)quinoline (en)
  • Imiquimodum (en)
  • R 837 (en)
  • Zartra (en)
http://linked.open...drugbank/toxicity
  • Symptoms of overdose include flu-like symptoms, such as fever, fatigue, headache, nausea, diarrhoea and muscle pain. (en)
http://linked.open.../drug/hasAHFSCode
http://linked.open...ogy/drugbank/salt
  • (en)
http://linked.open...ynthesisReference
  • "DrugSyn.org":http://www.drugsyn.org/Imiquimod.htm (en)
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http://linked.open...bank/Refractivity
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http://linked.open...ugbank/absorption
  • Well absorbed through skin (as a cream) (en)
http://linked.open.../affectedOrganism
  • Humans and other mammals (en)
http://linked.open...casRegistryNumber
  • 99011-02-6 (en)
http://linked.open...drugbank/category
  • (en)
http://linked.open...gbank/containedIn
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http://linked.open...-strongest-basic-
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