About: Procaine     Goto   Sponge   NotDistinct   Permalink

An Entity of Type : http://linked.opendata.cz/ontology/drugbank/Drug, within Data Space : linked.opendata.cz associated with source document(s)

AttributesValues
rdf:type
http://linked.open...gbank/description
  • A local anesthetic of the ester type that has a slow onset and a short duration of action. It is mainly used for infiltration anesthesia, peripheral nerve block, and spinal block. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1016). [PubChem] (en)
http://linked.open...generalReferences
  • # Gentry CL, Lukas RJ: Local anesthetics noncompetitively inhibit function of four distinct nicotinic acetylcholine receptor subtypes. J Pharmacol Exp Ther. 2001 Dec;299(3):1038-48. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/11714893 (en)
http://linked.open...gy/drugbank/group
  • approved (en)
  • investigational (en)
http://linked.open...drugbank/halfLife
  • 7.7 minutes (en)
http://linked.open...ugbank/indication
  • Used as a local anesthetic primarily in oral surgery (en)
http://linked.open...bank/manufacturer
sameAs
Title
  • Procaine (en)
adms:identifier
http://linked.open...mechanismOfAction
  • Procaine acts mainly by inhibiting sodium influx through voltage gated sodium channels in the neuronal cell membrane of peripheral nerves. When the influx of sodium is interrupted, an action potential cannot arise and signal conduction is thus inhibited. The receptor site is thought to be located at the cytoplasmic (inner) portion of the sodium channel. Procaine has also been shown to bind or antagonize the function of N-methyl-D-aspartate (NMDA) receptors as well as nicotinic acetylcholine receptors and the serotonin receptor-ion channel complex. (en)
http://linked.open...drugbank/packager
http://linked.open...outeOfElimination
  • With normal kidney function, the drug is excreted rapidly by tubular excretion. (en)
http://linked.open.../drugbank/synonym
  • Procaine (en)
  • Novocaine (en)
  • Vitamin H3 (en)
  • 2-Diethylaminoethyl p-aminobenzoate (en)
  • 4-Aminobenzoic acid 2-diethylaminoethyl ester (en)
  • Procaina (en)
  • Procainum (en)
  • beta-(Diethylamino)ethyl 4-aminobenzoate (en)
  • beta-(Diethylamino)ethyl P-aminobenzoate (en)
  • p-Aminobenzoic acid 2-diethylaminoethyl ester (en)
  • β-(diethylamino)ethyl 4-aminobenzoate (en)
  • β-(diethylamino)ethyl p-aminobenzoate (en)
http://linked.open.../drug/hasAHFSCode
http://linked.open...ogy/drugbank/salt
  • (en)
http://linked.open...y/mesh/hasConcept
foaf:page
http://linked.open...ugbank/IUPAC-Name
http://linked.open...gy/drugbank/InChI
http://linked.open...Molecular-Formula
http://linked.open.../Molecular-Weight
http://linked.open...noisotopic-Weight
http://linked.open...y/drugbank/SMILES
http://linked.open.../Water-Solubility
http://linked.open...ogy/drugbank/logP
http://linked.open...ogy/drugbank/logS
http://linked.open...logy/drugbank/pKa
http://linked.open...l/drug/hasATCCode
http://linked.open...nd-Acceptor-Count
http://linked.open...-Bond-Donor-Count
http://linked.open...drugbank/InChIKey
http://linked.open...urface-Area--PSA-
http://linked.open...nk/Polarizability
http://linked.open...bank/Refractivity
http://linked.open...atable-Bond-Count
http://linked.open.../affectedOrganism
  • Humans and other mammals (en)
http://linked.open...casRegistryNumber
  • 59-46-1 (en)
http://linked.open...drugbank/category
  • (en)
http://linked.open...gbank/containedIn
http://linked.open...k/Bioavailability
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