About: Tizanidine

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An Entity of Type : http://linked.opendata.cz/ontology/drugbank/Drug, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	http://linked.opendata.cz/ontology/drugbank/Drug
http://linked.open...gbank/description	Tizanidine is a short-acting drug for the management of spasticity. Tizanidine is an agonist at a2-adrenergic receptor sites and presumably reduces spasticity by increasing presynaptic inhibition of motor neurons. In animal models, tizanidine has no direct effect on skeletal muscle fibers or the neuromuscular junction, and no major effect on monosynaptic spinal reflexes. The effects of tizanidine are greatest on polysynaptic pathways. The overall effect of these actions is thought to reduce facilitation of spinal motor neurons. (en)
http://linked.open...y/drugbank/dosage	http://linked.opendata.cz/resource/drugbank/dosage/271B4857-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/dosage/271B4858-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/dosage/271B4859-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/dosage/271B485A-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/dosage/271B485F-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/dosage/271B485B-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/dosage/271B485C-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/dosage/271B485D-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/dosage/271B485E-363D-11E5-9242-09173F13E4C5
http://linked.open...gy/drugbank/group	approved (en)
http://linked.open...drugbank/halfLife	2.5 hours (en)
http://linked.open...ugbank/indication	For the management of increased muscle tone associated with spasticity (en)
http://linked.open...bank/manufacturer	Bristol laboratories inc div bristol myers co Abbott laboratories pharmaceutical products div Abbott laboratories hosp products div Abraxis pharmaceutical products Akorn inc Baxter healthcare corp anesthesia and critical care Alcon laboratories inc Alcon universal ltd Pfizer Inc. Ivax pharmaceuticals inc sub teva pharmaceuticals usa Hospira inc International medication systems ltd International medication system
sameAs	Tizanidine Tizanidine
Title	Tizanidine (en)
adms:identifier	http://linked.opendata.cz/resource/drugbank/drug/DB00697/identifier/bindingdb/50240671 http://linked.opendata.cz/resource/drugbank/drug/DB00697/identifier/chemspider/5287 http://linked.opendata.cz/resource/drugbank/drug/DB00697/identifier/drugbank/DB00697 http://linked.opendata.cz/resource/drugbank/drug/DB00697/identifier/kegg-compound/C07452 http://linked.opendata.cz/resource/drugbank/drug/DB00697/identifier/national-drug-code-directory/0378-0722-01 http://linked.opendata.cz/resource/drugbank/drug/DB00697/identifier/pubchem-compound/5487 http://linked.opendata.cz/resource/drugbank/drug/DB00697/identifier/pubchem-substance/46505373 http://linked.opendata.cz/resource/drugbank/drug/DB00697/identifier/pharmgkb/PA451701 http://linked.opendata.cz/resource/drugbank/drug/DB00697/identifier/wikipedia/Tizanidine
http://linked.open...mechanismOfAction	Tizanidine reduces spasticity by increasing presynaptic inhibition of motor neurons through agonist action at a2-adrenergic receptor sites. (en)
http://linked.open...drugbank/packager	Acorda Therapeutics Aidarex Pharmacuticals LLC APP Pharmaceuticals A-S Medication Solutions LLC Amerisource Health Services Corp. Amneal Pharmaceuticals Apotex Inc. A-S Medication Solutions LLC Procter & Gamble American antibiotics llc Cardinal Health Corepharma LLC Sandoz Dispensing Solutions Diversified Healthcare Services Inc. Doctor Reddys Laboratories Ltd. Apothecon sub bristol myers squibb co Pfizer Inc. Pharmaceutical Utilization Management Program VA Inc. Ivax pharmaceuticals inc sub teva pharmaceuticals usa Heartland Repack Services LLC Innoviant Pharmacy Inc. Sandoz Keltman Pharmaceuticals Inc. Lake Erie Medical and Surgical Supply Major Pharmaceuticals Murfreesboro Pharmaceutical Nursing Supply Mylan Nucare Pharmaceuticals Inc. Palmetto Pharmaceuticals Inc. Par Pharmaceuticals Patheon Inc. PCA LLC PD-Rx Pharmaceuticals Inc. Physicians Total Care Inc. Abic ltd Pharmacia and upjohn co Hospira inc Akorn Inc. Abraxis pharmaceutical products A-S Medication Solutions LLC Bausch & Lomb Inc. Dispensing Solutions Bioniche pharma usa llc Ebewe pharma ges mbh nfg kg Eye Supply Usa Inc.
http://linked.open...y/drugbank/patent	http://linked.opendata.cz/resource/drugbank/patent/6455557
http://linked.open...outeOfElimination	Approximately 95% of an administered dose is metabolized. (en)
http://linked.open.../drugbank/synonym	Tizanidine (en) Tizanidin (en) Tizanidina (en) Tizanidinum (en) 5-Chloro-4-(2-imidazolin-2-ylamino)-2,1,3-benzothiadiazole (en)
http://linked.open...umeOfDistribution	* 2.4 L/kg (en)
http://linked.open.../drug/hasAHFSCode	http://linked.opendata.cz/resource/AHFS/12-20-00
http://linked.open.../drugbank/mixture	Acent-TZ Amiox-K Amiox-P Carnil-MR Citanz

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