About: Sumatriptan

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An Entity of Type : http://linked.opendata.cz/ontology/drugbank/Drug, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	http://linked.opendata.cz/ontology/drugbank/Drug
http://linked.open...gbank/description	A serotonin agonist that acts selectively at 5HT1 receptors. It is used in the treatment of migraine disorders. A transdermal patch version of sumatriptan is currently in phase I trials in the U.S. under the code name NP101 (NuPathe). (en)
http://linked.open...y/drugbank/dosage	http://linked.opendata.cz/resource/drugbank/dosage/271B4078-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/dosage/271B4079-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/dosage/271B407A-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/dosage/271B407B-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/dosage/271B407C-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/dosage/271B407D-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/dosage/271B407E-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/dosage/271B407F-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/dosage/271B4080-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/dosage/271B4081-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/dosage/271B4082-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/dosage/271B4083-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/dosage/271B4084-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/dosage/271B4085-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/dosage/271B4086-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/dosage/271B4087-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/dosage/271B4088-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/dosage/271B4089-363D-11E5-9242-09173F13E4C5
http://linked.open...generalReferences	# Nikai T, Basbaum AI, Ahn AH: Profound reduction of somatic and visceral pain in mice by intrathecal administration of the anti-migraine drug, sumatriptan. Pain. 2008 Oct 31;139(3):533-40. Epub 2008 Aug 23. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/18723285 (en)
http://linked.open...gy/drugbank/group	approved (en) investigational (en)
http://linked.open...drugbank/halfLife	2.5 hours (en)
http://linked.open...ugbank/indication	For the treatment of migraine attacks with or without aura. (en)
http://linked.open...bank/manufacturer	Alpha Therapeutic Corp. American Red Cross Baxter International Inc. Bedford laboratories AstraZeneca Inc. CSL Behring LLC Astrazeneca pharmaceuticals lp Massachusetts Public Health Massbiologics Medimmune Inc. Novartis AG Aurobindo pharma ltd Dr reddys laboratories inc Glaxosmithkline Abbott Laboratories Ltd. A-S Medication Solutions LLC Aurobindo Pharma Ltd. Ceph International Corp. DAVA Pharmaceuticals Dispensing Solutions Diversified Healthcare Services Inc. Actavis Group
sameAs	Sumatriptan Sumatriptan
Title	Sumatriptan (en)
adms:identifier	http://linked.opendata.cz/resource/drugbank/drug/DB00669/identifier/chebi/10650 http://linked.opendata.cz/resource/drugbank/drug/DB00669/identifier/chemspider/5165 http://linked.opendata.cz/resource/drugbank/drug/DB00669/identifier/drugbank/DB00669 http://linked.opendata.cz/resource/drugbank/drug/DB00669/identifier/guide-to-pharmacology/119 http://linked.opendata.cz/resource/drugbank/drug/DB00669/identifier/iuphar/119 http://linked.opendata.cz/resource/drugbank/drug/DB00669/identifier/kegg-compound/C07319 http://linked.opendata.cz/resource/drugbank/drug/DB00669/identifier/kegg-drug/D00451 http://linked.opendata.cz/resource/drugbank/drug/DB00669/identifier/national-drug-code-directory/0173-0524-00 http://linked.opendata.cz/resource/drugbank/drug/DB00669/identifier/pharmgkb/PA451566 http://linked.opendata.cz/resource/drugbank/drug/DB00669/identifier/pubchem-compound/5358 http://linked.opendata.cz/resource/drugbank/drug/DB00669/identifier/pubchem-substance/46506520 http://linked.opendata.cz/resource/drugbank/drug/DB00669/identifier/wikipedia/Sumatriptan
http://linked.open...mechanismOfAction	The 5-HT<sub>1B</sub> and 5-HT<sub>1D</sub> receptors function as autoreceptors, which inhibit the firing of serotonin neurons and a reduction in the synthesis and release of serotonin upon activation. After sumatriptan binds to these receptors, adenylate cyclase activity is inhibited via regulatory G proteins, incrases intracellular calcium, and affects other intracellular events. This results in vasoconstriction and inhibtion of sensory nociceptive (trigeminal) nerve firing and vasoactive neuropeptide release. (en)
http://linked.open...drugbank/packager	Amgen Inc. Bausch and lomb pharmaceuticals inc Johnson & Johnson Healthcare Monarch Pharmacy Professional Co. Pharmaceutical Utilization Management Program VA Inc. Pharmaceutics International Inc. Apothecon inc div bristol myers squibb Allergan pharmaceutical Prepackage Specialists QPharm Inc. Qualitest Ranbaxy Laboratories Rebel Distributors Corp. Redpharm Drug Resource Optimization and Innovation LLC Sandoz Southwood Pharmaceuticals Unimed Pharmaceuticals Inc. Upsher Smith Laboratories Warner Chilcott Co. Inc. Watson Pharmaceuticals Wockhardt Ltd. Zogenix Inc. 3M Health Care Ivax pharmaceuticals inc sub teva pharmaceuticals usa Amerisource Health Services Corp. Apotheca Inc. APP Pharmaceuticals A-S Medication Solutions LLC Qualitest Aurobindo Pharma Ltd. AzurPharma Inc. Barr Pharmaceuticals Bayer Healthcare Bedford Labs Ben Venue Laboratories Inc.

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