| Attributes | Values |
|---|
| rdf:type
| |
| http://linked.open...gbank/description
| - An adrenergic agonist that acts predominantly at alpha adrenergic receptors and also stimulates the release of norepinephrine. It has been used primarily as a vasoconstrictor in the treatment of hypotension. [PubChem] (en)
|
| http://linked.open...generalReferences
| - # McDonald M, Santucci RA: Successful management of stuttering priapism using home self-injections of the alpha-agonist metaraminol. Int Braz J Urol. 2004 Mar-Apr;30(2):121-2. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/15703094 # Koga S, Shiraishi K, Saito Y: Post-traumatic priapism treated with metaraminol bitartrate: case report. J Trauma. 1990 Dec;30(12):1591-3. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/2258979 # Block T, Sturm W, Ernst G, Staehler G, Schmiedt E: [Metaraminol in therapy of various forms of priapism] Urologe A. 1988 Jul;27(4):225-9. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/3140463 (en)
|
| http://linked.open...gy/drugbank/group
| - approved (en)
- investigational (en)
|
| http://linked.open...ugbank/indication
| - For the treatment and prevention of hypotension due to hemorrhage, spinal anesthesia, and shock associated with brain damage (en)
|
| http://linked.open...bank/manufacturer
| |
| sameAs
| |
| Title
| |
| adms:identifier
| |
| http://linked.open...mechanismOfAction
| - Metaraminol acts through peripheral vasoconstriction by acting as a pure alpha-1 adrenergic receptor agonist, consequently increasing systemic blood pressure (both systolic & diastolic). Its effect is thought to be associated with the inhibition of adenyl cyclase which leads to an inhibition of the production of cAMP. Another effect of Metaraminol is that it releases norepinephrine from its storage sites indirectly. (en)
|
| http://linked.open...drugbank/packager
| |
| http://linked.open.../drugbank/synonym
| - Metaraminol (en)
- Hydroxynorephedrine (en)
- L-Metaraminol (en)
- (-)-Erythro-metaraminol (en)
- 1-(m-Hydroxyphenyl)-2-amino-1-propanol (en)
- 1-Metaraminol (en)
- 2-Amino-1-(m-hydroxyphenyl)-1-propanol (en)
- 3-Hydroxyphenylisopropanolamine (en)
- Metaraminolum (en)
- Métaraminol (en)
- alpha-(1-Aminoethyl)-3-hydroxybenzenemethanol (en)
- alpha-(m-Hydroxyphenyl)-beta-aminopropanol (en)
- m-Hydroxy norephedrine (en)
- m-Hydroxyphenylpropanolamine (en)
- m-Hydroxypropadrine (en)
|
| http://linked.open...drugbank/toxicity
| - LD<sub>50</sub>=240 mg/kg (rat, oral); LD<sub>50</sub>=99 mg/kg (mouse, oral) (en)
|
| http://linked.open...nk/proteinBinding
| |
| http://linked.open...ogy/drugbank/salt
| |
| http://linked.open...y/mesh/hasConcept
| |
| foaf:page
| |
| http://linked.open...ugbank/IUPAC-Name
| |
| http://linked.open...gy/drugbank/InChI
| |
| http://linked.open...Molecular-Formula
| |
| http://linked.open.../Molecular-Weight
| |
| http://linked.open...noisotopic-Weight
| |
| http://linked.open...y/drugbank/SMILES
| |
| http://linked.open.../Water-Solubility
| |
| http://linked.open...ogy/drugbank/logP
| |
| http://linked.open...ogy/drugbank/logS
| |
| http://linked.open...logy/drugbank/pKa
| |
| http://linked.open...l/drug/hasATCCode
| |
| http://linked.open...nd-Acceptor-Count
| |
| http://linked.open...-Bond-Donor-Count
| |
| http://linked.open...drugbank/InChIKey
| |
| http://linked.open...urface-Area--PSA-
| |
| http://linked.open...nk/Polarizability
| |
| http://linked.open...bank/Refractivity
| |
| http://linked.open...atable-Bond-Count
| |
| http://linked.open...ugbank/absorption
| - The effect starts 1-2 min after IV injection, 10 min after IM injection, 5-20 min after subcutaneous injection. (en)
|
| http://linked.open.../affectedOrganism
| - Humans and other mammals (en)
|
| http://linked.open...casRegistryNumber
| |
| http://linked.open...drugbank/category
| |
| http://linked.open...k/Bioavailability
| |
| http://linked.open...ank/Boiling-Point
| |
| http://linked.open...bank/Ghose-Filter
| |
| http://linked.open...nk/MDDR-Like-Rule
| |
| http://linked.open...ank/Melting-Point
| |
| http://linked.open...k/Number-of-Rings
| |
| http://linked.open...siological-Charge
| |
| http://linked.open...bank/Rule-of-Five
| |
| http://linked.open...tional-IUPAC-Name
| |
| http://linked.open...strongest-acidic-
| |
| http://linked.open...-strongest-basic-
| |
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