About: Nafcillin     Goto   Sponge   NotDistinct   Permalink

An Entity of Type : http://linked.opendata.cz/ontology/drugbank/Drug, within Data Space : linked.opendata.cz associated with source document(s)

AttributesValues
rdf:type
http://linked.open...gbank/description
  • A semi-synthetic antibiotic related to penicillin. [PubChem] (en)
http://linked.open...y/drugbank/dosage
http://linked.open...gy/drugbank/group
  • approved (en)
http://linked.open...drugbank/halfLife
  • The serum half-life of nafcillin administered by the intravenous route ranged from 33 to 61 minutes as measured in three separate studies. (en)
http://linked.open...ugbank/indication
  • For the treatment of infections caused by penicillinase-producing staphylococci which have demonstrated susceptibility to the drugs. (en)
http://linked.open...bank/manufacturer
sameAs
Title
  • Nafcillin (en)
adms:identifier
http://linked.open...mechanismOfAction
  • Penicillinase-resistant penicillins exert a bactericidal action against penicillin-susceptible microorganisms during the state of active multiplication. All penicillins inhibit the biosynthesis of the bacterial cell wall. (en)
http://linked.open...drugbank/packager
http://linked.open...outeOfElimination
  • Nafcillin is primarily eliminated by nonrenal routes, namely hepatic inactivation and excretion in the bile. (en)
http://linked.open.../drugbank/synonym
  • Naphcillin (en)
  • (2-Ethoxy-1-naphthalenyl)penicillin (en)
  • (2-Ethoxy-1-naphthyl)penicillin (en)
  • 6-(2-Ethoxy-1-naphthamido)penicillanic acid (en)
  • Nafcilina (en)
  • Nafcilline (en)
  • Nafcillinum (en)
  • (2S,5R,6R)-6-{[(2-ethoxynaphthalen-1-yl)carbonyl]amino}-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid (en)
http://linked.open...drugbank/toxicity
  • Serious toxicity is unlikely following large doses of nafcillin. Acute ingestion of large doses of nafcillin may cause nausea, vomiting, diarrhea and abdominal pain. Acute oliguric renal failure and hematuria may occur following large doses. (en)
http://linked.open...nk/proteinBinding
  • 89.9 ±1.5% (en)
http://linked.open...ogy/drugbank/salt
  • (en)
http://linked.open...y/mesh/hasConcept
foaf:page
http://linked.open...ugbank/IUPAC-Name
http://linked.open...gy/drugbank/InChI
http://linked.open...Molecular-Formula
http://linked.open.../Molecular-Weight
http://linked.open...noisotopic-Weight
http://linked.open...y/drugbank/SMILES
http://linked.open.../Water-Solubility
http://linked.open...ogy/drugbank/logP
http://linked.open...ogy/drugbank/logS
http://linked.open...l/drug/hasATCCode
http://linked.open...nd-Acceptor-Count
http://linked.open...-Bond-Donor-Count
http://linked.open...drugbank/InChIKey
http://linked.open...urface-Area--PSA-
http://linked.open...nk/Polarizability
http://linked.open...bank/Refractivity
http://linked.open...atable-Bond-Count
http://linked.open.../affectedOrganism
  • Enteric bacteria and other eubacteria (en)
  • Staphylococcus aureus (en)
http://linked.open...casRegistryNumber
  • 147-52-4 (en)
http://linked.open...drugbank/category
  • (en)
http://linked.open...gbank/containedIn
http://linked.open...k/Bioavailability
http://linked.open...bank/Ghose-Filter
http://linked.open...nk/MDDR-Like-Rule
http://linked.open...k/Number-of-Rings
http://linked.open...siological-Charge
http://linked.open...bank/Rule-of-Five
http://linked.open...tional-IUPAC-Name
http://linked.open...strongest-acidic-
http://linked.open...-strongest-basic-
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