About: Thiopental

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An Entity of Type : http://linked.opendata.cz/ontology/drugbank/Drug, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	http://linked.opendata.cz/ontology/drugbank/Drug
http://linked.open...gbank/description	A barbiturate that is administered intravenously for the induction of general anesthesia or for the production of complete anesthesia of short duration. It is also used for hypnosis and for the control of convulsive states. It has been used in neurosurgical patients to reduce increased intracranial pressure. It does not produce any excitation but has poor analgesic and muscle relaxant properties. Small doses have been shown to be anti-analgesic and lower the pain threshold. (From Martindale, The Extra Pharmacopoeia, 30th ed, p920) (en)
http://linked.open...generalReferences	# Morgan DJ, Blackman GL, Paull JD, Wolf LJ: Pharmacokinetics and plasma binding of thiopental. II: Studies at cesarean section. Anesthesiology. 1981 Jun;54(6):474-80. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/7235275 # Perez-Barcena J, Barcelo B, Homar J, Abadal JM, Molina FJ, de la Pena A, Sahuquillo J, Ibanez J: [Comparison of the effectiveness of pentobarbital and thiopental in patients with refractory intracranial hypertension. Preliminary report of 20 patients] Neurocirugia (Astur). 2005 Feb;16(1):5-12; discussion 12-3. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/15756405 # WINTERS WD, SPECTOR E, WALLACH DP, SHIDEMAN FE: Metabolism of thiopental-S35 and thiopental-2-C14 by a rat liver mince and identification of pentobarbital as a major metabolite. J Pharmacol Exp Ther. 1955 Jul;114(3):343-57. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/13243246 # Bory C, Chantin C, Boulieu R, Cotte J, Berthier JC, Fraisse D, Bobenrieth MJ: [Use of thiopental in man. Determination of this drug and its metabolites in plasma and urine by liquid phase chromatography and mass spectrometry] C R Acad Sci III. 1986;303(1):7-12. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/3093002 (en)
http://linked.open...gy/drugbank/group	approved (en)
http://linked.open...drugbank/halfLife	3-8 hours (en)
http://linked.open...ugbank/indication	For use as the sole anesthetic agent for brief (15 minute) procedures, for induction of anesthesia prior to administration of other anesthetic agents, to supplement regional anesthesia, to provide hypnosis during balanced anesthesia with other agents for analgesia or muscle relaxation, for the control of convulsive states during or following inhalation anesthesia or local anesthesia, in neurosurgical patients with increased intracranial pressure, and for narcoanalysis and narcosynthesis in psychiatric disorders. (en)
http://linked.open...bank/manufacturer	Abbott laboratories hosp products div
sameAs	Thiopental Thiopental
Title	Thiopental (en)
adms:identifier	http://linked.opendata.cz/resource/drugbank/drug/DB00599/identifier/chebi/102166 http://linked.opendata.cz/resource/drugbank/drug/DB00599/identifier/chemspider/2272258 http://linked.opendata.cz/resource/drugbank/drug/DB00599/identifier/drugbank/DB00599 http://linked.opendata.cz/resource/drugbank/drug/DB00599/identifier/guide-to-pharmacology/2579 http://linked.opendata.cz/resource/drugbank/drug/DB00599/identifier/iuphar/2579 http://linked.opendata.cz/resource/drugbank/drug/DB00599/identifier/kegg-compound/C07521 http://linked.opendata.cz/resource/drugbank/drug/DB00599/identifier/pharmgkb/PA451664 http://linked.opendata.cz/resource/drugbank/drug/DB00599/identifier/pubchem-compound/3000715 http://linked.opendata.cz/resource/drugbank/drug/DB00599/identifier/pubchem-substance/46504621 http://linked.opendata.cz/resource/drugbank/drug/DB00599/identifier/wikipedia/Thiopental
http://linked.open...mechanismOfAction	Thiopental binds at a distinct binding site associated with a Cl<sup>-</sup> ionopore at the GABA<sub>A</sub> receptor, increasing the duration of time for which the Cl<sup>-</sup> ionopore is open. The post-synaptic inhibitory effect of GABA in the thalamus is, therefore, prolonged. (en)
http://linked.open...drugbank/packager	Baxter International Inc. Hospira Inc. Lannett holdings inc
http://linked.open.../drugbank/synonym	Thiopental (en) Trapanal (en) Penthiobarbital (en) Pentothiobarbital (en) Thiopentobarbital (en) Thiopentobarbitone (en) Thiopentobarbituric acid (en) Thiopentone (en) (+-)-Thiopental (en) 2-Thio-5-ethyl-5-sec-pentylbarbituric acid (en) Bitaryl (en) Omexolon (en) Sodium Pentothal (en) Thiomebumalum (en) Tiopentale (en) 5-Ethyl-5-(1-methyl-butyl)-2-thioxo-dihydro-pyrimidine-4,6-dione (en)
http://linked.open...drugbank/toxicity	Overdosage may occur from too rapid or repeated injections. Too rapid injection may be followed by an alarming fall in blood pressure even to shock levels. Apnea, occasional laryngospasm, coughing and other respiratory difficulties with excessive or too rapid injections may occur. Lethal blood levels may be as low as 1 mg/100 mL for short-acting barbiturates; less if other depressant drugs or alcohol are also present. (en)
http://linked.open.../drug/hasAHFSCode	http://linked.opendata.cz/resource/AHFS/28-04-00
http://linked.open.../drugbank/mixture	Thiotal 5g
http://linked.open...nk/proteinBinding	Approximately 80% of the drug in the blood is bound to plasma protein. (en)
http://linked.open...y/mesh/hasConcept	http://linked.opendata.cz/resource/mesh/concept/M0021364
foaf:page	http://www.drugs.com/cdi/thiopental.html http://www.rxlist.com/cgi/generic3/thiopental.htm
http://linked.open...ugbank/IUPAC-Name	http://linked.opendata.cz/resource/drugbank/property/271B537D-363D-11E5-9242-09173F13E4C5
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http://linked.open...Molecular-Formula	http://linked.opendata.cz/resource/drugbank/property/271B5382-363D-11E5-9242-09173F13E4C5
http://linked.open.../Molecular-Weight	http://linked.opendata.cz/resource/drugbank/property/271B537F-363D-11E5-9242-09173F13E4C5
http://linked.open...noisotopic-Weight	http://linked.opendata.cz/resource/drugbank/property/271B5380-363D-11E5-9242-09173F13E4C5
http://linked.open...y/drugbank/SMILES	http://linked.opendata.cz/resource/drugbank/property/271B5381-363D-11E5-9242-09173F13E4C5
http://linked.open.../Water-Solubility	http://linked.opendata.cz/resource/drugbank/property/271B537B-363D-11E5-9242-09173F13E4C5
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http://linked.open...ogy/drugbank/logS	http://linked.opendata.cz/resource/drugbank/property/271B537A-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/property/271B5394-363D-11E5-9242-09173F13E4C5
http://linked.open...logy/drugbank/pKa	http://linked.opendata.cz/resource/drugbank/property/271B5395-363D-11E5-9242-09173F13E4C5
http://linked.open...l/drug/hasATCCode	Thiopental Thiopental
http://linked.open...nd-Acceptor-Count	http://linked.opendata.cz/resource/drugbank/property/271B5389-363D-11E5-9242-09173F13E4C5
http://linked.open...-Bond-Donor-Count	http://linked.opendata.cz/resource/drugbank/property/271B538A-363D-11E5-9242-09173F13E4C5
http://linked.open...drugbank/InChIKey	http://linked.opendata.cz/resource/drugbank/property/271B5384-363D-11E5-9242-09173F13E4C5
http://linked.open...urface-Area--PSA-	http://linked.opendata.cz/resource/drugbank/property/271B5385-363D-11E5-9242-09173F13E4C5
http://linked.open...nk/Polarizability	http://linked.opendata.cz/resource/drugbank/property/271B5387-363D-11E5-9242-09173F13E4C5
http://linked.open...bank/Refractivity	http://linked.opendata.cz/resource/drugbank/property/271B5386-363D-11E5-9242-09173F13E4C5
http://linked.open...atable-Bond-Count	http://linked.opendata.cz/resource/drugbank/property/271B5388-363D-11E5-9242-09173F13E4C5
http://linked.open...ugbank/absorption	Rapidly absorbed. (en)
http://linked.open.../affectedOrganism	Humans and other mammals (en)
http://linked.open...casRegistryNumber	76-75-5 (en)
http://linked.open...drugbank/category	(en)
http://linked.open...k/Bioavailability	http://linked.opendata.cz/resource/drugbank/property/271B538F-363D-11E5-9242-09173F13E4C5
http://linked.open...bank/Ghose-Filter	http://linked.opendata.cz/resource/drugbank/property/271B5391-363D-11E5-9242-09173F13E4C5
http://linked.open...nk/MDDR-Like-Rule	http://linked.opendata.cz/resource/drugbank/property/271B5392-363D-11E5-9242-09173F13E4C5
http://linked.open...k/Number-of-Rings	http://linked.opendata.cz/resource/drugbank/property/271B538E-363D-11E5-9242-09173F13E4C5
http://linked.open...siological-Charge	http://linked.opendata.cz/resource/drugbank/property/271B538D-363D-11E5-9242-09173F13E4C5
http://linked.open...bank/Rule-of-Five	http://linked.opendata.cz/resource/drugbank/property/271B5390-363D-11E5-9242-09173F13E4C5
http://linked.open...tional-IUPAC-Name	http://linked.opendata.cz/resource/drugbank/property/271B537E-363D-11E5-9242-09173F13E4C5
http://linked.open...strongest-acidic-	http://linked.opendata.cz/resource/drugbank/property/271B538B-363D-11E5-9242-09173F13E4C5
http://linked.open...-strongest-basic-	http://linked.opendata.cz/resource/drugbank/property/271B538C-363D-11E5-9242-09173F13E4C5

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