| Attributes | Values |
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| rdf:type
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| http://linked.open...gbank/description
| - Tolnaftate is a synthetic over-the-counter anti-fungal agent. It may come as a cream, powder, spray, or liquid aerosol, and is used to treat jock itch, athlete's foot and ringworm. It is sold under several brand names, most notably Tinactin and Odor Eaters. (en)
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| http://linked.open...y/drugbank/dosage
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| http://linked.open...generalReferences
| - # Barrett-Bee K, Dixon G: Ergosterol biosynthesis inhibition: a target for antifungal agents. Acta Biochim Pol. 1995;42(4):465-79. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/8852337 # Ryder NS, Frank I, Dupont MC: Ergosterol biosynthesis inhibition by the thiocarbamate antifungal agents tolnaftate and tolciclate. Antimicrob Agents Chemother. 1986 May;29(5):858-60. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/3524433 (en)
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| http://linked.open...gy/drugbank/group
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| http://linked.open...ugbank/indication
| - Tolnaftate topical is used to treat skin infections such as athlete's foot, jock itch, and ringworm infections. Tolnaftate is also used, along with other antifungals, to treat infections of the nails, scalp, palms, and soles of the feet. The powder and powder aerosol may be used to prevent athlete's foot. (en)
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| sameAs
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| Title
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| adms:identifier
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| http://linked.open...mechanismOfAction
| - Tolnaftate is a topical fungicide. Though its exact mechanism unknown, it is believed to prevent ergosterol biosynthesis by inhibiting squalene epoxidase. It has also been reported to distort the hyphae and to stunt mycelial growth in susceptible organisms. (en)
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| http://linked.open...drugbank/packager
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| http://linked.open.../drugbank/synonym
| - 2-Naphthyl N-methyl-N-(3-tolyl)thionocarbamate (en)
- Separin (en)
- Tinactin (en)
- Tolnaphthate (en)
- N-Methyl-N-(3-methylphenyl)-1-(naphthalen-2-yloxy)methanethioamide (en)
- O-2-Naphthyl m,N-dimethylthiocarbanilate (en)
- Tolnaftato (en)
- Tolnaftatum (en)
- m,N-Dimethylthiocarbanilic acid O-2-naphthyl ester (en)
- Methyl (3-methylphenyl)carbamothioic acid O-2-naphthalenyl ester (en)
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| http://linked.open...drugbank/toxicity
| - Oral rat LD50: 891 mg/kg. Inhalation rat LC50: > 900 mg/m3/1hr. Irritation: skin rabbit: 500 mg/24H mild. Eye rabbit: 100 mg severe. Investigated a mutagen and reproductive effector. (en)
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| http://linked.open.../drug/hasAHFSCode
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| http://linked.open.../drugbank/mixture
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| http://linked.open...ynthesisReference
| - Chris E. Platt, "Topical preparation of tolnaftate and hydrocortisone to treat fungal infections of the skin." U.S. Patent US5496812, issued November, 1989. (en)
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| foaf:page
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| http://linked.open...ugbank/IUPAC-Name
| |
| http://linked.open...gy/drugbank/InChI
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| http://linked.open...Molecular-Formula
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| http://linked.open.../Molecular-Weight
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| http://linked.open...noisotopic-Weight
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| http://linked.open...y/drugbank/SMILES
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| http://linked.open.../Water-Solubility
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| http://linked.open...ogy/drugbank/logP
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| http://linked.open...ogy/drugbank/logS
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| http://linked.open...l/drug/hasATCCode
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| http://linked.open...nd-Acceptor-Count
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| http://linked.open...-Bond-Donor-Count
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| http://linked.open...drugbank/InChIKey
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| http://linked.open...urface-Area--PSA-
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| http://linked.open...nk/Polarizability
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| http://linked.open...bank/Refractivity
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| http://linked.open...atable-Bond-Count
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| http://linked.open.../affectedOrganism
| - Yeast and other fungi (en)
|
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