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rdf:type
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http://linked.open...gbank/description
| - An important regulator of gene expression during growth and development, and in neoplasms. Tretinoin, also known as retinoic acid and derived from maternal vitamin A, is essential for normal growth; and embryonic development. An excess of tretinoin can be teratogenic. It is used in the treatment of psoriasis; acne vulgaris; and several other skin diseases. It has also been approved for use in promyelocytic leukemia (leukemia, promyelocytic, acute). [PubChem] (en)
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http://linked.open...y/drugbank/dosage
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http://linked.open...gy/drugbank/group
| - approved (en)
- investigational (en)
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http://linked.open...ugbank/indication
| - For topical treatment of cutaneous lesions in patients with AIDS-related Kaposi's sarcoma. (en)
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http://linked.open...bank/manufacturer
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sameAs
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Title
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adms:identifier
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http://linked.open...mechanismOfAction
| - Alitretinoin binds to and activates all known intracellular retinoid receptor subtypes (RARa, RARb, RARg, RXRa, RXRb and RXRg). Once activated these receptors function as transcription factors that regulate the expression of genes that control the process of cellular differentiation and proliferation in both normal and neoplastic cells. (en)
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http://linked.open...drugbank/packager
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http://linked.open...y/drugbank/patent
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http://linked.open.../drugbank/synonym
| - Alitretinoin (en)
- Panretin (en)
- Panretyn (en)
- 9-cis-Retinoic acid (en)
- (7e,9Z,11e,13e)-Retinoic acid (en)
- 9(Z)-Retinoic acid (en)
- 9-cis-Tretinoin (en)
- Alitretinoinum (en)
- Alitretinoína (en)
- Alitrétinoïne (en)
- (2e,4e,6Z,8e)-3,7-Dimethyl-9-(2,6,6-trimethyl-1-cyclohexen-1-yl)-2,4,6,8-nonatetraenoic acid (en)
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http://linked.open.../drug/hasAHFSCode
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http://linked.open...ynthesisReference
| - Hector F. DeLuca, Praveen K. Tadikonda, "Method of synthesis of retinoic acid." U.S. Patent US5808120, issued December, 1975. (en)
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http://linked.open...y/mesh/hasConcept
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foaf:page
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http://linked.open...ugbank/IUPAC-Name
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http://linked.open...gy/drugbank/InChI
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http://linked.open...Molecular-Formula
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http://linked.open.../Molecular-Weight
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http://linked.open...noisotopic-Weight
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http://linked.open...y/drugbank/SMILES
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http://linked.open.../Water-Solubility
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http://linked.open...ogy/drugbank/logP
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http://linked.open...ogy/drugbank/logS
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http://linked.open...l/drug/hasATCCode
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http://linked.open...nd-Acceptor-Count
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http://linked.open...-Bond-Donor-Count
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http://linked.open...drugbank/InChIKey
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http://linked.open...urface-Area--PSA-
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http://linked.open...nk/Polarizability
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http://linked.open...bank/Refractivity
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http://linked.open...atable-Bond-Count
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http://linked.open.../affectedOrganism
| - Humans and other mammals (en)
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http://linked.open...casRegistryNumber
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http://linked.open...drugbank/category
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http://linked.open...gbank/containedIn
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http://linked.open...k/Bioavailability
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http://linked.open...bank/Ghose-Filter
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http://linked.open...nk/MDDR-Like-Rule
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http://linked.open...ank/Melting-Point
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http://linked.open...k/Number-of-Rings
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http://linked.open...siological-Charge
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http://linked.open...bank/Rule-of-Five
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