About: Ritonavir     Goto   Sponge   NotDistinct   Permalink

An Entity of Type : http://linked.opendata.cz/ontology/drugbank/Drug, within Data Space : linked.opendata.cz associated with source document(s)

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http://linked.open...gbank/description
  • An HIV protease inhibitor that works by interfering with the reproductive cycle of HIV. [PubChem] (en)
http://linked.open...y/drugbank/dosage
http://linked.open...gy/drugbank/group
  • approved (en)
  • investigational (en)
http://linked.open...drugbank/halfLife
  • 3-5 hours (en)
http://linked.open...ugbank/indication
  • Indicated in combination with other antiretroviral agents for the treatment of HIV-infection. (en)
http://linked.open...bank/manufacturer
sameAs
Title
  • Ritonavir (en)
adms:identifier
http://linked.open...mechanismOfAction
  • Ritonavir inhibits the HIV viral proteinase enzyme which prevents cleavage of the gag-pol polyprotein, resulting in noninfectious, immature viral particles. (en)
http://linked.open...drugbank/packager
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  • Ritonavir (en)
  • Norvir (en)
  • Ritonavirum (en)
http://linked.open...drugbank/toxicity
  • Human experience of acute overdose with ritonavir is limited. One patient in clinical trials took ritonavir 1500 mg/day for two days. The patient reported paresthesias which resolved after the dose was decreased. A post-marketing case of renal failure with eosinophilia has been reported with ritonavir overdose. The approximate lethal dose was found to be greater than 20 times the related human dose in rats and 10 times the related human dose in mice. (en)
http://linked.open.../drug/hasAHFSCode
http://linked.open...k/foodInteraction
  • Avoid St.John's Wort. (en)
  • Take with food. (en)
http://linked.open.../drugbank/mixture
http://linked.open...nk/proteinBinding
  • 98-99% (en)
http://linked.open...ynthesisReference
  • "DrugSyn.org":http://www.drugsyn.org/Ritonavir.htm (en)
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foaf:page
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  • The absolute bioavailability of ritonavir has not been determined. (en)
http://linked.open.../affectedOrganism
  • Human Immunodeficiency Virus (en)
http://linked.open...casRegistryNumber
  • 155213-67-5 (en)
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http://linked.open...-strongest-basic-
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