About: Buspirone

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An Entity of Type : http://linked.opendata.cz/ontology/drugbank/Drug, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	http://linked.opendata.cz/ontology/drugbank/Drug
http://linked.open...gbank/description	An anxiolytic agent and a serotonin receptor agonist belonging to the azaspirodecanedione class of compounds. Its structure is unrelated to those of the benzodiazepines, but it has an efficacy comparable to diazepam. [PubChem] (en)
http://linked.open...y/drugbank/dosage	http://linked.opendata.cz/resource/drugbank/dosage/271B5D4E-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/dosage/271B5D4F-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/dosage/271B5D50-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/dosage/271B5D51-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/dosage/271B5D52-363D-11E5-9242-09173F13E4C5
http://linked.open...gy/drugbank/group	approved (en) investigational (en)
http://linked.open...drugbank/halfLife	2-3 hours (although the action of a single dose is much longer than the short halflife indicates). (en)
http://linked.open...ugbank/indication	For the management of anxiety disorders or the short-term relief of the symptoms of anxiety, and also as an augmention of SSRI-treatment against depression. (en)
http://linked.open...bank/manufacturer	Dispensing Solutions Actavis totowa llc Apotex inc Dr reddys laboratories ltd Janssen-Ortho Inc. Ivax pharmaceuticals inc sub teva pharmaceuticals usa Kv pharmaceutical co McNeil Laboratories Amerisource Health Services Corp. Atlantic Biologicals Corporation Comprehensive Consultant Services Inc.
sameAs	Buspirone Buspirone
Title	Buspirone (en)
adms:identifier	http://linked.opendata.cz/resource/drugbank/drug/DB00490/identifier/chebi/3223 http://linked.opendata.cz/resource/drugbank/drug/DB00490/identifier/chemspider/2383 http://linked.opendata.cz/resource/drugbank/drug/DB00490/identifier/drugbank/DB00490 http://linked.opendata.cz/resource/drugbank/drug/DB00490/identifier/guide-to-pharmacology/36 http://linked.opendata.cz/resource/drugbank/drug/DB00490/identifier/iuphar/36 http://linked.opendata.cz/resource/drugbank/drug/DB00490/identifier/kegg-compound/C06861 http://linked.opendata.cz/resource/drugbank/drug/DB00490/identifier/national-drug-code-directory/0378-1140-01 http://linked.opendata.cz/resource/drugbank/drug/DB00490/identifier/pharmgkb/PA448689 http://linked.opendata.cz/resource/drugbank/drug/DB00490/identifier/pubchem-compound/2477 http://linked.opendata.cz/resource/drugbank/drug/DB00490/identifier/pubchem-substance/46508113 http://linked.opendata.cz/resource/drugbank/drug/DB00490/identifier/wikipedia/Buspirone
http://linked.open...mechanismOfAction	Buspirone binds to 5-HT type 1A serotonin receptors on presynaptic neurons in the dorsal raphe and on postsynaptic neurons in the hippocampus, thus inhibiting the firing rate of 5-HT-containing neurons in the dorsal raphe. Buspirone also binds at dopamine type 2 (DA2) receptors, blocking presynaptic dopamine receptors. Buspirone increases firing in the locus ceruleus, an area of brain where norepinephrine cell bodies are found in high concentration. The net result of buspirone actions is that serotonergic activity is suppressed while noradrenergic and dopaminergic cell firing is enhanced. (en)
http://linked.open...drugbank/packager	Advanced Pharmaceutical Services Inc. Advanced Pharmaceutical Services Inc. Amend AQ Pharmaceuticals Inc. A-S Medication Solutions LLC Apothecary Shop Wholesale AQ Pharmaceuticals Inc. A-S Medication Solutions LLC Pfizer Inc. Bryant Ranch Prepack C.O. Truxton Inc. Cadista Pharmaceuticals Inc. Cardinal Health Carlisle Laboratories Inc. Comprehensive Consultant Services Inc. Corepharma LLC Darby Dental Supply Co. Inc. Dept Health Central Pharmacy Direct Dispensing Inc. Dispensing Solutions Diversified Healthcare Services Inc. H.J. Harkins Co. Inc. Heartland Repack Services LLC Innoviant Pharmacy Inc. Kaiser Foundation Hospital Keltman Pharmaceuticals Inc. Lake Erie Medical and Surgical Supply Liberty Pharmaceuticals Major Pharmaceuticals Mckesson Corp. Pharmaceutical Utilization Management Program VA Inc. Cephalon Inc. Diversified Healthcare Services Inc. Heartland Repack Services LLC Innoviant Pharmacy Inc. Nucare Pharmaceuticals Inc. Advanced Pharmaceutical Services Inc. Amerisource Health Services Corp. Apotex Inc. Apotheca Inc. Apothecon AQ Pharmaceuticals Inc. A-S Medication Solutions LLC PCA LLC PD-Rx Pharmaceuticals Inc. Perrigo Co. Pharmacia Inc. Pharmedix Physicians Total Care Inc. Preferred Pharmaceuticals Inc. Prepackage Specialists Prepak Systems Inc. Prescription Dispensing Service Inc. Alza Corp. Atlantic Biologicals Corporation Cardinal Health Dept Health Central Pharmacy
http://linked.open...outeOfElimination	In a single-dose study using 14C-labeled buspirone, 29% to 63% of the dose was excreted in the urine within 24 hours, primarily as metabolites; fecal excretion accounted for 18% to 38% of the dose. (en)
http://linked.open.../drugbank/synonym	Buspirone (en) 8-(4-(4-(2-Pyrimidinyl)-1-piperizinyl)butyl)-8-azaspiro(4,5)decane-7,9-dione (en) Buspiron (en) Buspirona (en) Buspironum (en)

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