About: Chlorpromazine     Goto   Sponge   NotDistinct   Permalink

An Entity of Type : http://linked.opendata.cz/ontology/drugbank/Drug, within Data Space : linked.opendata.cz associated with source document(s)

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http://linked.open...gbank/description
  • The prototypical phenothiazine antipsychotic drug. Like the other drugs in this class, chlorpromazine's antipsychotic actions are thought to be due to long-term adaptation by the brain to blocking dopamine receptors. Chlorpromazine has several other actions and therapeutic uses, including as an antiemetic and in the treatment of intractable hiccup. [PubChem] (en)
http://linked.open...y/drugbank/dosage
http://linked.open...generalReferences
  • # Leucht S, Wahlbeck K, Hamann J, Kissling W: New generation antipsychotics versus low-potency conventional antipsychotics: a systematic review and meta-analysis. Lancet. 2003 May 10;361(9369):1581-9. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/12747876 (en)
http://linked.open...gy/drugbank/group
  • approved (en)
http://linked.open...drugbank/halfLife
  • ~ 30 hours (en)
http://linked.open...ugbank/indication
  • For the treatment of schizophrenia, control nausea and vomiting, For relief of restlessness and apprehension before surgery, adjunct in the treatment of tetanus, control the manifestations of the manic type of manic-depressive illness. (en)
http://linked.open...bank/manufacturer
sameAs
Title
  • Chlorpromazine (en)
adms:identifier
http://linked.open...mechanismOfAction
  • Chlorpromazine acts as an antagonist (blocking agent) on different postsysnaptic receptors -on dopaminergic-receptors (subtypes D1, D2, D3 and D4 - different antipsychotic properties on productive and unproductive symptoms), on serotonergic-receptors (5-HT1 and 5-HT2, with anxiolytic, antidepressive and antiaggressive properties as well as an attenuation of extrapypramidal side-effects, but also leading to weight gain, fall in blood pressure, sedation and ejaculation difficulties), on histaminergic-receptors (H1-receptors, sedation, antiemesis, vertigo, fall in blood pressure and weight gain), alpha1/alpha2-receptors (antisympathomimetic properties, lowering of blood pressure, reflex tachycardia, vertigo, sedation, hypersalivation and incontinence as well as sexual dysfunction, but may also attenuate pseudoparkinsonism - controversial) and finally on muscarinic (cholinergic) M1/M2-receptors (causing anticholinergic symptoms like dry mouth, blurred vision, obstipation, difficulty/inability to urinate, sinus tachycardia, ECG-changes and loss of memory, but the anticholinergic action may attenuate extrapyramidal side-effects). Additionally, Chlorpromazine is a weak presynaptic inhibitor of Dopamine reuptake, which may lead to (mild) antidepressive and antiparkinsonian effects. This action could also account for psychomotor agitation and amplification of psychosis (very rarely noted in clinical use). (en)
http://linked.open...drugbank/packager
http://linked.open...outeOfElimination
  • Kidneys, ~ 37% excreted in urine (en)
http://linked.open.../drugbank/synonym
  • Chlorpromazine (en)
  • Largactil (en)
  • Thorazine (en)
  • Aminazine (en)
  • CPZ (en)
  • Chlorderazin (en)
  • Chloropromazine (en)
  • Chlorpromados (en)
  • Chlorpromazinum (en)
  • Clorpromazina (en)
  • Contomin (en)
  • N-(3-Dimethylaminopropyl)-3-chlorophenothiazine (en)
  • 3-(2-chloro-10H-Phenothiazin-10-yl)-N,N-dimethyl-1-propanamine (en)
  • 3-(2-Chlorophenothiazin-10-yl)-N,N-dimethyl-propan-1-amine (en)
http://linked.open...drugbank/toxicity
  • Agitation, coma, convulsions, difficulty breathing, difficulty swallowing, dry mouth, extreme sleepiness, fever, intestinal blockage, irregular heart rate, low blood pressure, restlessness (en)
http://linked.open...umeOfDistribution
  • * 20 L/kg (en)
http://linked.open.../drug/hasAHFSCode
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