About: Prochlorperazine

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An Entity of Type : http://linked.opendata.cz/ontology/drugbank/Drug, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	http://linked.opendata.cz/ontology/drugbank/Drug
http://linked.open...gbank/description	A phenothiazine antipsychotic used principally in the treatment of nausea; vomiting; and vertigo. It is more likely than chlorpromazine to cause extrapyramidal disorders. (From Martindale, The Extra Pharmacopoeia, 30th ed, p612) (en)
http://linked.open...y/drugbank/dosage	http://linked.opendata.cz/resource/drugbank/dosage/271B4D67-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/dosage/271B4D68-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/dosage/271B4D69-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/dosage/271B4D6A-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/dosage/271B4D6B-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/dosage/271B4D64-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/dosage/271B4D65-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/dosage/271B4D66-363D-11E5-9242-09173F13E4C5
http://linked.open...gy/drugbank/group	approved (en)
http://linked.open...drugbank/halfLife	6 to 8 hours (en)
http://linked.open...ugbank/indication	For the symptomatic management of psychotic disorders, short term management of nonpsychotic anxiety in patients with generalized anxiety disorder, and for the control of severe nausea and vomiting of various causes. (en)
http://linked.open...bank/manufacturer	Able laboratories inc Corepharma LLC Coupler Enterprises Inc. DAVA Pharmaceuticals Alpharma us pharmaceuticals division DHHS Program Support Center Supply Service Center Baxter healthcare corp anesthesia and critical care Dispensing Solutions Excellium Pharmaceutical Inc. Ivax pharmaceuticals inc sub teva pharmaceuticals usa A-S Medication Solutions LLC Excella GmbH Gilead Sciences Inc. Advanced Pharmaceutical Services Inc. APP Pharmaceuticals Doctor Reddys Laboratories Ltd. AstraZeneca Inc. E.R. Squibb and Sons LLC Endo Pharmaceuticals Inc. App pharmaceuticals llc
sameAs	Prochlorperazine Prochlorperazine
Title	Prochlorperazine (en)
adms:identifier	http://linked.opendata.cz/resource/drugbank/drug/DB00433/identifier/chebi/8435 http://linked.opendata.cz/resource/drugbank/drug/DB00433/identifier/chemspider/4748 http://linked.opendata.cz/resource/drugbank/drug/DB00433/identifier/drugbank/DB00433 http://linked.opendata.cz/resource/drugbank/drug/DB00433/identifier/kegg-compound/C07403 http://linked.opendata.cz/resource/drugbank/drug/DB00433/identifier/kegg-drug/D00493 http://linked.opendata.cz/resource/drugbank/drug/DB00433/identifier/national-drug-code-directory/0574-7226-12 http://linked.opendata.cz/resource/drugbank/drug/DB00433/identifier/pubchem-compound/4917 http://linked.opendata.cz/resource/drugbank/drug/DB00433/identifier/pubchem-substance/46509018 http://linked.opendata.cz/resource/drugbank/drug/DB00433/identifier/pharmgkb/PA451114 http://linked.opendata.cz/resource/drugbank/drug/DB00433/identifier/wikipedia/Prochlorperazine
http://linked.open...mechanismOfAction	The mechanism of action of prochlorperazine has not been fully determined, but may be primarily related to its antidopaminergic effects. Prochlorperazine blocks the D2 somatodendritic autoreceptor, resulting in the blockade of postsynaptic dopamine receptors in the mesolimbic system and an increased dopamine turnover. Prochlorperazine also has anti-emetic effects, which can be attributed to dopamine blockade in the chemoreceptor trigger zone. Prochlorperazine also blocks anticholinergic and alpha-adrenergic receptors, the blockade of alpha(1)-adrenergic receptors resulting in sedation, muscle relaxation, and hypotension. (en)
http://linked.open...drugbank/packager	Alphapharm Party Ltd. Apotex Inc. Bergen Brunswig Bio Pharm Inc. Actavis Group A-S Medication Solutions LLC Alaven Pharmaceutical Baxter International Inc. Bedford Labs Alphagen Laboratories Inc. Bryant Ranch Prepack Amend Anip Acquisition Co. Apotheca Inc. Aristos Pharmaceuticals A-S Medication Solutions LLC A-S Medication Solutions LLC Atlantic Biologicals Corporation Atley Pharmaceuticals Auriga Pharmaceuticals LLC Direct Dispensing Inc. Blansett Pharmacal Co. Inc. Boca Pharmacal Bradley Pharmaceuticals Inc. Breckenridge Pharmaceuticals Bryant Ranch Prepack Abbott Laboratories Ltd. Actavis Group Advanced Pharmaceutical Services Inc. Aidarex Pharmacuticals LLC Amerisource Health Services Corp. Apotex Inc. Apotheca Inc. A-S Medication Solutions LLC Pharmaceutical Utilization Management Program VA Inc. Atlantic Biologicals Corporation Aurobindo Pharma Ltd. Barr Pharmaceuticals Sandoz Bristol-Myers Squibb Co. Bryant Ranch Prepack BTA Pharmaceuticals C.O. Truxton Inc. Cadista Pharmaceuticals Inc. Aurobindo pharma ltd Sandoz Cardinal Health Carlisle Laboratories Inc. Central Texas Community Health Centers Roxane laboratories inc Comprehensive Consultant Services Inc.
http://linked.open.../drugbank/synonym	Capazine (en) Emetiral (en)

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