About: Lindane

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An Entity of Type : http://linked.opendata.cz/ontology/drugbank/Drug, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	http://linked.opendata.cz/ontology/drugbank/Drug
http://linked.open...gbank/description	An organochlorine insecticide that has been used as a pediculicide and a scabicide. Lindane has been banned in California, United Kingdom, Australia, and many western countries due to concerns about neurotoxicity and adverse effects on the environment. In Canada, Lindane is not recommmended as a first-line therapy due to reports of resistance, neurotoxicity, and bone marrow suppression, but has been approved by the FDA as a second-line therapy for topical treatment of pediculosis capitis (head lice), pediculosis pubis (pubic lice), or scabies in patients greater than two years of age who cannot tolerate or have failed first-line treatment. Lindane is still allowed for pharmaceutical use until 2015. (en)
http://linked.open...y/drugbank/dosage	http://linked.opendata.cz/resource/drugbank/dosage/271B4CBD-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/dosage/271B4CBE-363D-11E5-9242-09173F13E4C5
http://linked.open...generalReferences	# Brown VJ: Life after lindane in California. Environ Health Perspect. 2008 Mar;116(3):A128. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/18335087 # Strong M, Johnstone PW: Interventions for treating scabies. Cochrane Database Syst Rev. 2007 Jul 18;(3):CD000320. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/17636630 (en)
http://linked.open...gy/drugbank/group	approved (en) withdrawn (en)
http://linked.open...drugbank/halfLife	18 hours (en)
http://linked.open...ugbank/indication	For the treatment of patients infested with Sarcoptes scabiei or pediculosis capitis who have either failed to respond to adequate doses, or are intolerant of other approved therapies. (en)
http://linked.open...bank/manufacturer	Bristol myers squibb co Banner pharmacaps inc Chase chemical co lp Everylife Impax laboratories inc
sameAs	Lindane Lindane
Title	Lindane (en)
adms:identifier	http://linked.opendata.cz/resource/drugbank/drug/DB00431/identifier/chebi/32888 http://linked.opendata.cz/resource/drugbank/drug/DB00431/identifier/drugbank/DB00431 http://linked.opendata.cz/resource/drugbank/drug/DB00431/identifier/kegg-compound/C07075 http://linked.opendata.cz/resource/drugbank/drug/DB00431/identifier/kegg-drug/D00360 http://linked.opendata.cz/resource/drugbank/drug/DB00431/identifier/national-drug-code-directory/45068-100-01 http://linked.opendata.cz/resource/drugbank/drug/DB00431/identifier/pharmgkb/PA164754914 http://linked.opendata.cz/resource/drugbank/drug/DB00431/identifier/wikipedia/Lindane
http://linked.open...mechanismOfAction	Lindane is an organochloride insecticide that has similar neurotoxic protperties to DDT. It exerts its parasiticidal action by being directly absorbed through the parasite's exoskeleton (primarily lice, or scabies) and their ova. The gamma-aminobutyric acid (GABA(1)) receptor/chloride ionophore complex is the primary site of action for lindane, and other insecticides such as endosulfan, and fipronil. Blockage of the GABA-gated chloride channel reduces neuronal inhibition, which leads to hyperexcitation of the central nervous system. This results in paralysis, convulsions, and death. Lindane has very low ovicidal activity. (en)
http://linked.open...drugbank/packager	Pfizer Inc. Alliant Pharmaceuticals Inc. Apotheca Inc. Century Pharmaceuticals Inc. Dept Health Central Pharmacy Dispensing Solutions Major Pharmaceuticals Eli lilly and co App pharmaceuticals llc Orit laboratories llc Pharmachemie bv Strides arcolab ltd
http://linked.open.../drugbank/synonym	Kwell (en) Benzene hexachloride (en) Lindan (en) gamma-BHC (en) gamma-HCH (en) gamma-Hexachlorocyclohexane (en) γ-Hexachlorzyklohexan (en) γ-hexachlorocyclohexane (en) γ-lindane (en) 1,2,3,4,5,6-Hexachlorocyclohexane (en) Gammallin (en) Gammaxene (en) (1R,2c,3t,4c,5c,6t)-1,2,3,4,5,6-Hexachlorocyclohexane (en) gamma-1,2,3,4,5,6-Hexachlorocyclohexane (en) gamma-Benzene hexachloride (en) gamma-Hexachlorzyklohexan (en) gamma-Lindane (en) (1alpha,2alpha,3beta,4alpha,5alpha,6beta)-1,2,3,4,5,6-Hexachlorocyclohexane (en)
http://linked.open...drugbank/toxicity	Lindane is a moderately toxic compound via oral exposure, with a reported oral LD<sub>50</sub> of 88 to 190 mg/kg in rats. Gamma-HCH (which constitutes 99% of lindane) is generally considered to be the most acutely toxic of the isomers following single administration. It is moderately toxic via the dermal route as well, with reported dermal LD<sub>50</sub> values of 500 to 1000 mg/kg in rats, 300 mg/kg in mice, 400 mg/kg in guinea pigs, and 300 mg/kg in rabbits. Acute exposure to lindane may lead to central nervous system stimulation (usually developing within 1 hour), mental/motor impairment, excitation, clonic (intermittent) and tonic (continuous) convulsion. Other adverse reactions include central nervous system toxicity, as well as skin and gastrointestinal changes. (en)
http://linked.open.../drug/hasAHFSCode	http://linked.opendata.cz/resource/AHFS/84-04-12 http://linked.opendata.cz/resource/AHFS/84-04-92
http://linked.open.../drugbank/mixture	Allergy Sinus Medication - Caplet
http://linked.open...nk/proteinBinding	91% (en)
http://linked.open...y/mesh/hasConcept	http://linked.opendata.cz/resource/mesh/concept/M0002334
foaf:page	http://www.drugs.com/cdi/lindane-lotion.html http://www.rxlist.com/cgi/generic2/lindane.htm
http://linked.open...ugbank/IUPAC-Name	http://linked.opendata.cz/resource/drugbank/property/271B4CC3-363D-11E5-9242-09173F13E4C5
http://linked.open...gy/drugbank/InChI	http://linked.opendata.cz/resource/drugbank/property/271B4CC9-363D-11E5-9242-09173F13E4C5
http://linked.open...Molecular-Formula	http://linked.opendata.cz/resource/drugbank/property/271B4CC8-363D-11E5-9242-09173F13E4C5
http://linked.open.../Molecular-Weight	http://linked.opendata.cz/resource/drugbank/property/271B4CC5-363D-11E5-9242-09173F13E4C5
http://linked.open...noisotopic-Weight	http://linked.opendata.cz/resource/drugbank/property/271B4CC6-363D-11E5-9242-09173F13E4C5
http://linked.open...y/drugbank/SMILES	http://linked.opendata.cz/resource/drugbank/property/271B4CC7-363D-11E5-9242-09173F13E4C5
http://linked.open.../Water-Solubility	http://linked.opendata.cz/resource/drugbank/property/271B4CD7-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/property/271B4CC1-363D-11E5-9242-09173F13E4C5
http://linked.open...ogy/drugbank/logP	http://linked.opendata.cz/resource/drugbank/property/271B4CDA-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/property/271B4CBF-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/property/271B4CC2-363D-11E5-9242-09173F13E4C5
http://linked.open...ogy/drugbank/logS	http://linked.opendata.cz/resource/drugbank/property/271B4CC0-363D-11E5-9242-09173F13E4C5
http://linked.open...l/drug/hasATCCode	Lindane
http://linked.open...nd-Acceptor-Count	http://linked.opendata.cz/resource/drugbank/property/271B4CCF-363D-11E5-9242-09173F13E4C5
http://linked.open...-Bond-Donor-Count	http://linked.opendata.cz/resource/drugbank/property/271B4CD0-363D-11E5-9242-09173F13E4C5
http://linked.open...drugbank/InChIKey	http://linked.opendata.cz/resource/drugbank/property/271B4CCA-363D-11E5-9242-09173F13E4C5
http://linked.open...urface-Area--PSA-	http://linked.opendata.cz/resource/drugbank/property/271B4CCB-363D-11E5-9242-09173F13E4C5
http://linked.open...nk/Polarizability	http://linked.opendata.cz/resource/drugbank/property/271B4CCD-363D-11E5-9242-09173F13E4C5
http://linked.open...bank/Refractivity	http://linked.opendata.cz/resource/drugbank/property/271B4CCC-363D-11E5-9242-09173F13E4C5
http://linked.open...atable-Bond-Count	http://linked.opendata.cz/resource/drugbank/property/271B4CCE-363D-11E5-9242-09173F13E4C5
http://linked.open...ugbank/absorption	Lindane is absorbed significantly through the skin. A mean peak blood concentration of 28 nanograms per mL occurred in infants and children 6 hours after total body application of lindane lotion for scabies. (en)
http://linked.open.../affectedOrganism	Scabies (Sarcoptes scabei) and other insects (en)
http://linked.open...casRegistryNumber	58-89-9 (en)
http://linked.open...drugbank/category	(en)
http://linked.open...gbank/containedIn	Apokyn 30 mg/3 ml cartridge Doxorubicin 50 mg vial Lindane 1% Shampoo 60ml Bottle
http://linked.open...k/Bioavailability	http://linked.opendata.cz/resource/drugbank/property/271B4CD3-363D-11E5-9242-09173F13E4C5
http://linked.open...ank/Boiling-Point	http://linked.opendata.cz/resource/drugbank/property/271B4CD9-363D-11E5-9242-09173F13E4C5
http://linked.open...bank/Ghose-Filter	http://linked.opendata.cz/resource/drugbank/property/271B4CD5-363D-11E5-9242-09173F13E4C5
http://linked.open...nk/MDDR-Like-Rule	http://linked.opendata.cz/resource/drugbank/property/271B4CD6-363D-11E5-9242-09173F13E4C5
http://linked.open...ank/Melting-Point	http://linked.opendata.cz/resource/drugbank/property/271B4CD8-363D-11E5-9242-09173F13E4C5
http://linked.open...k/Number-of-Rings	http://linked.opendata.cz/resource/drugbank/property/271B4CD2-363D-11E5-9242-09173F13E4C5
http://linked.open...siological-Charge	http://linked.opendata.cz/resource/drugbank/property/271B4CD1-363D-11E5-9242-09173F13E4C5
http://linked.open...bank/Rule-of-Five	http://linked.opendata.cz/resource/drugbank/property/271B4CD4-363D-11E5-9242-09173F13E4C5
http://linked.open...tional-IUPAC-Name	http://linked.opendata.cz/resource/drugbank/property/271B4CC4-363D-11E5-9242-09173F13E4C5

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