About: Streptozocin

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About: Streptozocin Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/drugbank/Drug, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	http://linked.opendata.cz/ontology/drugbank/Drug
http://linked.open...gbank/description	An antibiotic that is produced by Stretomyces achromogenes. It is used as an antineoplastic agent and to induce diabetes in experimental animals. [PubChem] (en)
http://linked.open...y/drugbank/dosage	http://linked.opendata.cz/resource/drugbank/dosage/271B4C48-363D-11E5-9242-09173F13E4C5
http://linked.open...generalReferences	# "Link":http://www.bccancer.bc.ca/HPI/DrugDatabase/DrugIndexPro/Streptozocin.htm # Brentjens R, Saltz L: Islet cell tumors of the pancreas: the medical oncologist's perspective. Surg Clin North Am. 2001 Jun;81(3):527-42. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/11459269 # Wang Z, Gleichmann H: GLUT2 in pancreatic islets: crucial target molecule in diabetes induced with multiple low doses of streptozotocin in mice. Diabetes. 1998 Jan;47(1):50-6. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/9421374 # Schnedl WJ, Ferber S, Johnson JH, Newgard CB: STZ transport and cytotoxicity. Specific enhancement in GLUT2-expressing cells. Diabetes. 1994 Nov;43(11):1326-33. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/7926307 # VAVRA JJ, DEBOER C, DIETZ A, HANKA LJ, SOKOLSKI WT: Streptozotocin, a new antibacterial antibiotic. Antibiot Annu. 1959-1960;7:230-5. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/13841501 # Mansford KR, Opie L: Comparison of metabolic abnormalities in diabetes mellitus induced by streptozotocin or by alloxan. Lancet. 1968 Mar 30;1(7544):670-1. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/4170654 (en)
http://linked.open...gy/drugbank/group	approved (en)
http://linked.open...drugbank/halfLife	5-15 minutes (en)
http://linked.open...ugbank/indication	For the treatment of malignant neoplasms of pancreas (metastatic islet cell carcinoma). (en)
http://linked.open...bank/manufacturer	Alza Corp.
sameAs	Streptozocin Streptozocin
Title	Streptozocin (en)
adms:identifier	http://linked.opendata.cz/resource/drugbank/drug/DB00428/identifier/chebi/9288 http://linked.opendata.cz/resource/drugbank/drug/DB00428/identifier/chemspider/27273 http://linked.opendata.cz/resource/drugbank/drug/DB00428/identifier/drugbank/DB00428 http://linked.opendata.cz/resource/drugbank/drug/DB00428/identifier/kegg-drug/D05932 http://linked.opendata.cz/resource/drugbank/drug/DB00428/identifier/national-drug-code-directory/0703-4636-01 http://linked.opendata.cz/resource/drugbank/drug/DB00428/identifier/pubchem-compound/29327 http://linked.opendata.cz/resource/drugbank/drug/DB00428/identifier/pubchem-substance/46508872 http://linked.opendata.cz/resource/drugbank/drug/DB00428/identifier/pharmgkb/PA451514 http://linked.opendata.cz/resource/drugbank/drug/DB00428/identifier/wikipedia/Streptozocin
http://linked.open...mechanismOfAction	Although its mechanism of action is not completely clear, streptozocin is known to inhibit DNA synthesis, interfere with biochemical reactions of NAD and NADH, and inhibit some enzymes involved in gluconeogenesis. Its activity appears to occur as a result of formation of methylcarbonium ions, which alkylate or bind with many intracellular molecular structures including nucleic acids. Its cytotoxic action is probably due to cross-linking of strands of DNA, resulting in inhibition of DNA synthesis. (en)
http://linked.open...drugbank/packager	AAIPharma Inc. Actavis Group Advanced Pharmaceutical Services Inc.
http://linked.open...outeOfElimination	As much as 20% of the drug (or metabolites containing an N-nitrosourea group) is metabolized and/or excreted by the kidney. (en)
http://linked.open.../drugbank/synonym	Streptozocin (en) Zanosar (en) Streptozotocin (en) 2-Deoxy-2-(3-methyl-3-nitrosoureido)-D-glucopyranose (en) Estreptozocina (en) N-D-Glucosyl-(2)-n'-nitrosomethylharnstoff (en) N-D-Glucosyl-(2)-n'-nitrosomethylurea (en) Streptozocine (en) Streptozocinium (en) Streptozocinum (en) 2-Deoxy-2-(((methylnitrosoamino)carbonyl)amino)-D-glucopyranose (en)
http://linked.open...drugbank/toxicity	Symptoms of overdose include nausea and vomiting, anorexia, myelosuppression; and nephrotoxicity. (en)
http://linked.open.../drug/hasAHFSCode	http://linked.opendata.cz/resource/AHFS/10-00-00
foaf:page	http://www.drugs.com/cdi/streptozocin.html http://www.rxlist.com/cgi/generic/zanosar.htm
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http://linked.open...ugbank/absorption	Poor oral absorption (17-25%) (en)
http://linked.open.../affectedOrganism	Humans and other mammals (en)
http://linked.open...casRegistryNumber	18883-66-4 (en)
http://linked.open...drugbank/category	(en)
http://linked.open...gbank/containedIn	Apo-Perphenazine 4 mg Tablet
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