About: Trihexyphenidyl

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An Entity of Type : http://linked.opendata.cz/ontology/drugbank/Drug, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	http://linked.opendata.cz/ontology/drugbank/Drug
http://linked.open...gbank/description	One of the centrally acting muscarinic antagonists used for treatment of parkinsonian disorders and drug-induced extrapyramidal movement disorders and as an antispasmodic. [PubChem] (en)
http://linked.open...y/drugbank/dosage	http://linked.opendata.cz/resource/drugbank/dosage/271B63ED-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/dosage/271B63EE-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/dosage/271B63EF-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/dosage/271B63F0-363D-11E5-9242-09173F13E4C5
http://linked.open...gy/drugbank/group	approved (en)
http://linked.open...drugbank/halfLife	3.3-4.1 hours (en)
http://linked.open...ugbank/indication	Indicated for the treatment of parkinson's disease and extrapyramidal reactions caused by drugs. (en)
http://linked.open...bank/manufacturer	Lederle laboratories div american cyanamid co Mikart inc Bristol myers co Pharmaceutical ventures ltd Schering corp sub schering plough corp Nylos trading co inc Vangard laboratories inc div midway medical co Vintage pharmaceuticals inc Watson laboratories inc West ward pharmaceutical corp
sameAs	Trihexyphenidyl Trihexyphenidyl
Title	Trihexyphenidyl (en)
adms:identifier	http://linked.opendata.cz/resource/drugbank/drug/DB00376/identifier/chemspider/5371 http://linked.opendata.cz/resource/drugbank/drug/DB00376/identifier/drugbank/DB00376 http://linked.opendata.cz/resource/drugbank/drug/DB00376/identifier/kegg-compound/C07171 http://linked.opendata.cz/resource/drugbank/drug/DB00376/identifier/national-drug-code-directory/61748-054-36 http://linked.opendata.cz/resource/drugbank/drug/DB00376/identifier/pubchem-compound/5572 http://linked.opendata.cz/resource/drugbank/drug/DB00376/identifier/pubchem-substance/46507717 http://linked.opendata.cz/resource/drugbank/drug/DB00376/identifier/pharmgkb/PA164747026 http://linked.opendata.cz/resource/drugbank/drug/DB00376/identifier/wikipedia/Trihexyphenidyl
http://linked.open...mechanismOfAction	Trihexyphenidyl is a selective M1 muscarinic acetylcholine receptor antagonist. It is able to discriminate between the M1 (cortical or neuronal) and the peripheral muscarinic subtypes (cardiac and glandular). Trihexyphenidyl partially blocks cholinergic activity in the CNS, which is responsible for the symptoms of Parkinson's disease. It is also thought to increase the availability of dopamine, a brain chemical that is critical in the initiation and smooth control of voluntary muscle movement. (en)
http://linked.open...drugbank/packager	Advanced Pharmaceutical Services Inc. Amerisource Health Services Corp. Comprehensive Consultant Services Inc. Direct Dispensing Inc. American therapeutics inc DSM Corp. Gilead Sciences Inc. Mikart Inc. 21st Century Healthcare Inc. Equaline Vitamins Freeda Vitamins Pharmaceutical Utilization Management Program VA Inc. APP Pharmaceuticals APPD Baxter International Inc. Bedford Labs Ben Venue Laboratories Inc. Bristol-Myers Squibb Co. Mead Johnson and Co. Pharmachemie BV Sicor Pharmaceuticals Teva Pharmaceutical Industries Ltd. App pharmaceuticals llc West-Ward Pharmaceuticals
http://linked.open.../drugbank/synonym	Trihexyphenidyl (en) Apo-trihex (en) Benzhexol Hydrochloride (en) Trihexifenidilo (en) Trihexyphenidylum (en) Trihexyphénidyle (en) (RS)-1-cyclohexyl-1-phenyl-3-(1-piperidyl)propan-1-ol (en)
http://linked.open...drugbank/toxicity	Symptoms of overdose include mydriasis, dryness of mucous membranes, red face, atonic states of bowels and bladder, and hyperthermia in high doses. Central consequences are agitation, confusion, and hallucinations. An untreated overdose may be fatal, particular in children. Premortal signs are respiratory depression and cardiac arrest. (en)
http://linked.open.../drug/hasAHFSCode	http://linked.opendata.cz/resource/AHFS/12-08-04
http://linked.open.../drugbank/mixture	Hexiflu-T Krisp-T Lacalm Plus
http://linked.open...ogy/drugbank/salt	(en)
http://linked.open...y/mesh/hasConcept	http://linked.opendata.cz/resource/mesh/concept/M0021972
foaf:page	http://www.drugs.com/cdi/trihexyphenidyl.html http://www.rxlist.com/cgi/generic3/trihexyphen.htm
http://linked.open...ugbank/IUPAC-Name	http://linked.opendata.cz/resource/drugbank/property/271B63F5-363D-11E5-9242-09173F13E4C5
http://linked.open...gy/drugbank/InChI	http://linked.opendata.cz/resource/drugbank/property/271B63FB-363D-11E5-9242-09173F13E4C5
http://linked.open...Molecular-Formula	http://linked.opendata.cz/resource/drugbank/property/271B63FA-363D-11E5-9242-09173F13E4C5
http://linked.open.../Molecular-Weight	http://linked.opendata.cz/resource/drugbank/property/271B63F7-363D-11E5-9242-09173F13E4C5
http://linked.open...noisotopic-Weight	http://linked.opendata.cz/resource/drugbank/property/271B63F8-363D-11E5-9242-09173F13E4C5
http://linked.open...y/drugbank/SMILES	http://linked.opendata.cz/resource/drugbank/property/271B63F9-363D-11E5-9242-09173F13E4C5
http://linked.open.../Water-Solubility	http://linked.opendata.cz/resource/drugbank/property/271B63F3-363D-11E5-9242-09173F13E4C5
http://linked.open...ogy/drugbank/logP	http://linked.opendata.cz/resource/drugbank/property/271B63F1-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/property/271B63F4-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/property/271B640C-363D-11E5-9242-09173F13E4C5
http://linked.open...ogy/drugbank/logS	http://linked.opendata.cz/resource/drugbank/property/271B63F2-363D-11E5-9242-09173F13E4C5
http://linked.open...l/drug/hasATCCode	Trihexyphenidyl
http://linked.open...nd-Acceptor-Count	http://linked.opendata.cz/resource/drugbank/property/271B6401-363D-11E5-9242-09173F13E4C5
http://linked.open...-Bond-Donor-Count	http://linked.opendata.cz/resource/drugbank/property/271B6402-363D-11E5-9242-09173F13E4C5
http://linked.open...drugbank/InChIKey	http://linked.opendata.cz/resource/drugbank/property/271B63FC-363D-11E5-9242-09173F13E4C5
http://linked.open...urface-Area--PSA-	http://linked.opendata.cz/resource/drugbank/property/271B63FD-363D-11E5-9242-09173F13E4C5
http://linked.open...nk/Polarizability	http://linked.opendata.cz/resource/drugbank/property/271B63FF-363D-11E5-9242-09173F13E4C5
http://linked.open...bank/Refractivity	http://linked.opendata.cz/resource/drugbank/property/271B63FE-363D-11E5-9242-09173F13E4C5
http://linked.open...atable-Bond-Count	http://linked.opendata.cz/resource/drugbank/property/271B6400-363D-11E5-9242-09173F13E4C5
http://linked.open...ugbank/absorption	Trihexyphenidyl is rapidly absorbed from the gastrointestinal tract. (en)
http://linked.open.../affectedOrganism	Humans and other mammals (en)
http://linked.open...casRegistryNumber	144-11-6 (en)
http://linked.open...drugbank/category	(en)
http://linked.open...gbank/containedIn	Apo-Trihex 2 mg Tablet Apo-Trihex 5 mg Tablet Trihexyphenidyl 2 mg tablet Trihexyphenidyl HCl 2 mg tablet Trihexyphenidyl 5 mg tablet Trihexyphenidyl HCl 5 mg tablet

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