| Attributes | Values |
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| rdf:type
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| http://linked.open...gbank/description
| - 17-Hydroxy-6-methylpregna-3,6-diene-3,20-dione. A progestational hormone used most commonly as the acetate ester. As the acetate, it is more potent than progesterone both as a progestagen and as an ovulation inhibitor. It has also been used in the palliative treatment of breast cancer. [PubChem] (en)
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| http://linked.open...y/drugbank/dosage
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| http://linked.open...generalReferences
| - # Berenstein EG, Ortiz Z: Megestrol acetate for the treatment of anorexia-cachexia syndrome. Cochrane Database Syst Rev. 2005 Apr 18;(2):CD004310. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/15846706 # Pascual Lopez A, Roque i Figuls M, Urrutia Cuchi G, Berenstein EG, Almenar Pasies B, Balcells Alegre M, Herdman M: Systematic review of megestrol acetate in the treatment of anorexia-cachexia syndrome. J Pain Symptom Manage. 2004 Apr;27(4):360-9. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/15050664 # Rao GG, Miller DS: Hormonal therapy in epithelial ovarian cancer. Expert Rev Anticancer Ther. 2006 Jan;6(1):43-7. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/16375643 # Schindler AE, Campagnoli C, Druckmann R, Huber J, Pasqualini JR, Schweppe KW, Thijssen JH: Classification and pharmacology of progestins. Maturitas. 2008 Sep-Oct;61(1-2):171-80. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/19434889 # Orme LM, Bond JD, Humphrey MS, Zacharin MR, Downie PA, Jamsen KM, Mitchell SL, Robinson JM, Grapsas NA, Ashley DM: Megestrol acetate in pediatric oncology patients may lead to severe, symptomatic adrenal suppression. Cancer. 2003 Jul 15;98(2):397-405. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/12872362 (en)
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| http://linked.open...gy/drugbank/group
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| http://linked.open...drugbank/halfLife
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| http://linked.open...ugbank/indication
| - For the treatment of anorexia, cachexia, or an unexplained, significant weight loss in patients with a diagnosis of acquired immunodeficiency syndrome (AIDS). Also used for the palliative management of recurrent, inoperable, or metastatic breast cancer, endometrial cancer, and prostate cancer in Canada and some other countries. (en)
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| http://linked.open...bank/manufacturer
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| sameAs
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| Title
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| adms:identifier
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| http://linked.open...mechanismOfAction
| - The precise mechanism by which megestrol acetate produces effects in anorexia and cachexia is unknown at the present time, but its progestin antitumour activity may involve suppression of luteinizing hormone by inhibition of pituitary function. Studies also suggest that the megestrol's weight gain effect is related to its appetite-stimulant or metabolic effects rather than its glucocorticoid-like effects or the production of edema. It has also been suggested that megestrol may alter metabolic pathyways via interferences with the production or action of mediators such as cachectin, a hormone that inhibits adipocyte lipogenic enzymes. (en)
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| http://linked.open...drugbank/packager
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| http://linked.open...y/drugbank/patent
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| http://linked.open...outeOfElimination
| - The major route of drug elimination in humans is urine. Respiratory excretion as labeled carbon dioxide and fat storage may have accounted for at least part of the radioactivity not found in urine and feces. (en)
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| http://linked.open.../drugbank/synonym
| - Magestin (en)
- Megace (en)
- Megeron (en)
- Niagestin (en)
- Ovaban (en)
- Ovarid (en)
- MGA (en)
- 17α-Hydroxy-6-methylpregna-4,6-diene-3,20-dione acetate (en)
- 6-Methyl-delta(sup 4,6)-pregnadien-17α-ol-3,20-dione acetate (en)
- 17-Acetoxy-6-methylpregna-4,6-diene-3,20-dione (en)
- 17alpha-Acetoxy-6-dehydro-6-methylprogesterone (en)
- 17α-Acetoxy-6-dehydro-6-methylprogesterone (en)
- 6-Dehydro-6-methyl-17alpha-acetoxyprogesterone (en)
- 6-Dehydro-6-methyl-17α-acetoxyprogesterone (en)
- 6-Methyl-17α-acetoxypregna-4,6-diene-3,20-dione (en)
- 6-Methyl-6-dehydro-17alpha-acetoxyprogesterone (en)
- 6-Methyl-6-dehydro-17α-acetoxyprogesterone (en)
- 6-Methyl-delta(sup 4,6)-pregnadien-17alpha-ol-3,20-dione acetate (en)
- Maygace (en)
- Megestat (en)
- Megestil (en)
- Megestin (en)
- 6-Methyl-17alpha-acetoxypregna-4,6-diene-3,20-dione (en)
- 6-Methyl-17alpha-hydroxy-delta(sup 6)-progesterone acetate (en)
- Volidan (en)
- 6-Methyl-delta(sup 6)-dehydro-17alpha-acetoxyprogesterone (en)
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