About: Omeprazole

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An Entity of Type : http://linked.opendata.cz/ontology/drugbank/Drug, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	http://linked.opendata.cz/ontology/drugbank/Drug
http://linked.open...gbank/description	A highly effective inhibitor of gastric acid secretion used in the therapy of stomach ulcers and Zollinger-Ellison syndrome. Omeprazole belongs to a class of antisecretory compounds, the substituted benzimidazoles, that suppress gastric acid secretion by specific inhibition of the H+/K+ ATPase enzyme system at the secretory surface of the gastric parietal cell. (en)
http://linked.open...y/drugbank/dosage	http://linked.opendata.cz/resource/drugbank/dosage/271B59DA-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/dosage/271B59DB-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/dosage/271B59DC-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/dosage/271B59DD-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/dosage/271B59DE-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/dosage/271B59DF-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/dosage/271B59E0-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/dosage/271B59E1-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/dosage/271B59E2-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/dosage/271B59E3-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/dosage/271B59E4-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/dosage/271B59E5-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/dosage/271B59E6-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/dosage/271B59E7-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/dosage/271B59E8-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/dosage/271B59E9-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/dosage/271B59EA-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/dosage/271B59EB-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/dosage/271B59EC-363D-11E5-9242-09173F13E4C5
http://linked.open...generalReferences	# Yang YX, Lewis JD, Epstein S, Metz DC: Long-term proton pump inhibitor therapy and risk of hip fracture. JAMA. 2006 Dec 27;296(24):2947-53. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/17190895 # FDA label (en)
http://linked.open...gy/drugbank/group	approved (en) investigational (en)
http://linked.open...drugbank/halfLife	0.5-1 hour (healthy subjects, delayed-release capsule); 3 hours (hepatic impairment) (en)
http://linked.open...ugbank/indication	Omeprazole is indicated for the treatment of duodenal ulcers, benign gastric ulcers, gastroesophageal reflux disease (GERD), heartburn and other symptoms associated with GERD, erosive esophagitis, and long-term treatment of pathological hypersecretory conditions like Zollinger-Ellison syndrome, multiple endocrine adenomas, and systemic mastocytosis. (en)
http://linked.open...bank/manufacturer	Actavis Group Aidarex Pharmacuticals LLC Alphagen Laboratories Inc. American Regent Amerisource Health Services Corp. Amneal Pharmaceuticals Apotheca Inc. APP Pharmaceuticals A-S Medication Solutions LLC Athlon Pharmaceuticals Inc. Atley Pharmaceuticals
sameAs	Omeprazole Omeprazole
Title	Omeprazole (en)
adms:identifier	http://linked.opendata.cz/resource/drugbank/drug/DB00338/identifier/bindingdb/50241343 http://linked.opendata.cz/resource/drugbank/drug/DB00338/identifier/chebi/7772 http://linked.opendata.cz/resource/drugbank/drug/DB00338/identifier/chemspider/4433 http://linked.opendata.cz/resource/drugbank/drug/DB00338/identifier/drugbank/DB00338 http://linked.opendata.cz/resource/drugbank/drug/DB00338/identifier/guide-to-pharmacology/4279 http://linked.opendata.cz/resource/drugbank/drug/DB00338/identifier/iuphar/4279 http://linked.opendata.cz/resource/drugbank/drug/DB00338/identifier/kegg-compound/C07324 http://linked.opendata.cz/resource/drugbank/drug/DB00338/identifier/kegg-drug/D00455 http://linked.opendata.cz/resource/drugbank/drug/DB00338/identifier/national-drug-code-directory/63739-358-10 http://linked.opendata.cz/resource/drugbank/drug/DB00338/identifier/pubchem-compound/4594 http://linked.opendata.cz/resource/drugbank/drug/DB00338/identifier/pubchem-substance/46509065 http://linked.opendata.cz/resource/drugbank/drug/DB00338/identifier/pharmgkb/PA450704 http://linked.opendata.cz/resource/drugbank/drug/DB00338/identifier/wikipedia/Omeprazole
http://linked.open...mechanismOfAction	Omeprazole is a proton pump inhibitor that suppresses gastric acid secretion by specific inhibition of the H<sup>+</sup>/K<sup>+</sup>-ATPase in the gastric parietal cell. By acting specifically on the proton pump, omeprazole blocks the final step in acid production, thus reducing gastric acidity. (en)
http://linked.open...drugbank/packager	Aidarex Pharmacuticals LLC Altura Pharmaceuticals Inc. Amerisource Health Services Corp. Abbott laboratories pharmaceutical products div A-S Medication Solutions LLC Endo Pharmaceuticals Inc. AstraZeneca Inc. Advanced Pharmaceutical Services Inc. Amerisource Health Services Corp. Apotex Inc. Ivax pharmaceuticals inc sub teva pharmaceuticals usa Bristol-Myers Squibb Co. Cardinal Health Comprehensive Consultant Services Inc. Dept Health Central Pharmacy Corepharma LLC Coupler Enterprises Inc. CVS Pharmacy Dept Health Central Pharmacy Dexcel Ltd. DHHS Program Support Center Supply Service Center Dispensing Solutions Diversified Healthcare Services Inc. Doctor Reddys Laboratories Ltd. Pharmascience Inc. Alra laboratories inc Golden State Medical Supply Inc. Dr reddys laboratories inc Heartland Repack Services LLC Alaven Pharmaceutical Sandoz General Injectables and Vaccines Inc. Keltman Pharmaceuticals Inc. Advanced Pharmaceutical Services Inc. AG Marin Pharmaceuticals Alaven Pharmaceutical Advanced Pharmaceutical Services Inc. AQ Pharmaceuticals Inc. A-S Medication Solutions LLC AstraZeneca Inc. Atlantic Biologicals Corporation Bio Pharm Inc. Bradley Pharmaceuticals Inc. Breckenridge Pharmaceuticals Bristol-Myers Squibb Co. Cardinal Health

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