About: Amsacrine     Goto   Sponge   NotDistinct   Permalink

An Entity of Type : http://linked.opendata.cz/ontology/drugbank/Drug, within Data Space : linked.opendata.cz associated with source document(s)

AttributesValues
rdf:type
http://linked.open...gbank/description
  • Aminoacridine derivative that is a potent intercalating antineoplastic agent. It is effective in the treatment of acute leukemias and malignant lymphomas, but has poor activity in the treatment of solid tumors. It is frequently used in combination with other antineoplastic agents in chemotherapy protocols. It produces consistent but acceptable myelosuppression and cardiotoxic effects. [PubChem] (en)
http://linked.open...generalReferences
  • # "Link":http://www.bccancer.bc.ca/HPI/DrugDatabase/DrugIndexPro/Amsacrine.htm (en)
http://linked.open...gy/drugbank/group
  • approved (en)
http://linked.open...drugbank/halfLife
  • 8-9 hours (en)
http://linked.open...ugbank/indication
  • For treatment of acute myeloid leukaemia. (en)
sameAs
Title
  • Amsacrine (en)
adms:identifier
http://linked.open...mechanismOfAction
  • Amsacrine binds to DNA through intercalation and external binding. It has a base specificity for A-T pairs. Rapidly dividing cells are two to four times more sensitive to amsacrine than are resting cells. Amsacrine appears to cleave DNA by inducing double stranded breaks. Amsacrine also targets and inhibits topoisomerase II. Cytotoxicity is greatest during the S phase of the cell cycle when topoisomerase levels are at a maximum. (en)
http://linked.open.../drugbank/synonym
  • Amsacrine (en)
  • m-AMSA (en)
  • 4'-(9-Acridinylamino)methanesulfon-m-anisidide (en)
  • 4'-(9-Acridinylamino)methanesulfon-meta-anisidide (en)
  • 4'-(9-Acridinylamino)methanesulphon-m-anisidide (en)
  • Acridinyl anisidide (en)
  • mAMSA (en)
  • 4'-(9-Acridinylamino)-3'-methoxymethanesulfonanilide (en)
http://linked.open...drugbank/toxicity
  • Symptoms of overdose include nausea and vomiting, diarrhea, some cardiotoxicity (rarely). (en)
http://linked.open.../drug/hasAHFSCode
http://linked.open...nk/proteinBinding
  • 96-98% (en)
http://linked.open...y/mesh/hasConcept
http://linked.open...ugbank/IUPAC-Name
http://linked.open...gy/drugbank/InChI
http://linked.open...Molecular-Formula
http://linked.open.../Molecular-Weight
http://linked.open...noisotopic-Weight
http://linked.open...y/drugbank/SMILES
http://linked.open.../Water-Solubility
http://linked.open...ogy/drugbank/logP
http://linked.open...ogy/drugbank/logS
http://linked.open...l/drug/hasATCCode
http://linked.open...nd-Acceptor-Count
http://linked.open...-Bond-Donor-Count
http://linked.open...drugbank/InChIKey
http://linked.open...urface-Area--PSA-
http://linked.open...nk/Polarizability
http://linked.open...bank/Refractivity
http://linked.open...atable-Bond-Count
http://linked.open...ugbank/absorption
  • Poorly absorbed (en)
http://linked.open.../affectedOrganism
  • Humans and other mammals (en)
http://linked.open...casRegistryNumber
  • 51264-14-3 (en)
http://linked.open...drugbank/category
  • (en)
http://linked.open...k/Bioavailability
http://linked.open...bank/Ghose-Filter
http://linked.open...nk/MDDR-Like-Rule
http://linked.open...ank/Melting-Point
http://linked.open...k/Number-of-Rings
http://linked.open...siological-Charge
http://linked.open...bank/Rule-of-Five
http://linked.open...tional-IUPAC-Name
http://linked.open...strongest-acidic-
http://linked.open...-strongest-basic-
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