About: Metoprolol

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An Entity of Type : http://linked.opendata.cz/ontology/drugbank/Drug, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	http://linked.opendata.cz/ontology/drugbank/Drug
http://linked.open...gbank/description	Metoprolol is a cardioselective β1-adrenergic blocking agent used for acute myocardial infarction (MI), heart failure, angina pectoris and mild to moderate hypertension. It may also be used for supraventricular and tachyarrhythmias and prophylaxis for migraine headaches. Metoprolol is structurally similar to bisoprolol, acebutolol and atenolol in that it has two substituents in the <i>para</i> position of the benzene ring. The β1-selectivity of these agents is thought to be due in part to the large substituents in the <i>para</i> position. At low doses, metoprolol selectively blocks cardiac β1-adrenergic receptors with little activity against β2-adrenergic receptors of the lungs and vascular smooth muscle. Receptor selectivity decreases with higher doses. Unlike propranolol and pindolol, metoprolol does not exhibit membrane-stabilizing or intrinsic sympathomimetic activity. Membrane-stabilizing effects are only observed at doses much higher than those needed for β-adrenergic blocking activity. Metoprolol possesses a single chiral centre and is administered as a racemic mixture. (en)
http://linked.open...y/drugbank/dosage	http://linked.opendata.cz/resource/drugbank/dosage/271B4325-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/dosage/271B4326-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/dosage/271B4327-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/dosage/271B4328-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/dosage/271B4329-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/dosage/271B432A-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/dosage/271B432B-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/dosage/271B432C-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/dosage/271B432D-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/dosage/271B432E-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/dosage/271B432F-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/dosage/271B4330-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/dosage/271B4331-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/dosage/271B4332-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/dosage/271B4333-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/dosage/271B4334-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/dosage/271B4335-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/dosage/271B4336-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/dosage/271B4337-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/dosage/271B4338-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/dosage/271B4339-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/dosage/271B433A-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/dosage/271B433B-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/dosage/271B433C-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/dosage/271B433D-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/dosage/271B433E-363D-11E5-9242-09173F13E4C5
http://linked.open...generalReferences	# : Effect of metoprolol CR/XL in chronic heart failure: Metoprolol CR/XL Randomised Intervention Trial in Congestive Heart Failure (MERIT-HF) Lancet. 1999 Jun 12;353(9169):2001-7. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/10376614 (en)
http://linked.open...gy/drugbank/group	approved (en) investigational (en)
http://linked.open...drugbank/halfLife	3-7 hours (en)
http://linked.open...ugbank/indication	For the management of acute myocardial infarction, angina pectoris, heart failure and mild to moderate hypertension. May be used to treat supraventricular and tachyarrhythmias and as prophylaxis for migraine headaches. (en)
http://linked.open...bank/manufacturer	Neuman Distributors Inc. Kv pharmaceutical co Nucare Pharmaceuticals Inc. Palmetto Pharmaceuticals Inc. PD-Rx Pharmaceuticals Inc. Pfizer Inc. Pharmaceutical Utilization Management Program VA Inc. Hikma farmaceutica (portugal) sa Hospira inc Luitpold pharmaceuticals inc Prasco Labs Sandoz canada inc Preferred Pharmaceuticals Inc. Apothecon inc div bristol myers squibb Aurobindo pharma ltd Caraco pharmaceutical laboratories ltd Bayer pharmaceuticals corp Mallinckrodt medical inc Mylan pharmaceuticals inc Purepac pharmaceutical co RP Scherer Canada Inc. Sandhills Packaging Inc. Schering Corp.
sameAs	Metoprolol Metoprolol
Title	Metoprolol (en)
adms:identifier	http://linked.opendata.cz/resource/drugbank/drug/DB00264/identifier/bindingdb/25756 http://linked.opendata.cz/resource/drugbank/drug/DB00264/identifier/chebi/6904 http://linked.opendata.cz/resource/drugbank/drug/DB00264/identifier/chemspider/4027 http://linked.opendata.cz/resource/drugbank/drug/DB00264/identifier/drugbank/DB00264 http://linked.opendata.cz/resource/drugbank/drug/DB00264/identifier/guide-to-pharmacology/553 http://linked.opendata.cz/resource/drugbank/drug/DB00264/identifier/iuphar/553 http://linked.opendata.cz/resource/drugbank/drug/DB00264/identifier/kegg-compound/C07202 http://linked.opendata.cz/resource/drugbank/drug/DB00264/identifier/kegg-drug/D02358 http://linked.opendata.cz/resource/drugbank/drug/DB00264/identifier/national-drug-code-directory/58177-293-04 http://linked.opendata.cz/resource/drugbank/drug/DB00264/identifier/pubchem-compound/4171 http://linked.opendata.cz/resource/drugbank/drug/DB00264/identifier/pubchem-substance/46506211 http://linked.opendata.cz/resource/drugbank/drug/DB00264/identifier/pharmgkb/PA450480 http://linked.opendata.cz/resource/drugbank/drug/DB00264/identifier/wikipedia/Metoprolol
http://linked.open...mechanismOfAction	Metoprolol competes with adrenergic neurotransmitters such as catecholamines for binding at beta(1)-adrenergic receptors in the heart. Beta(1)-receptor blockade results in a decrease in heart rate, cardiac output, and blood pressure. (en)
http://linked.open...drugbank/packager	Sandoz Amerisource Health Services Corp. Apothecon AQ Pharmaceuticals Inc. A-S Medication Solutions LLC Patient First Corp. AstraZeneca Inc. Atlantic Biologicals Corporation Aurobindo Pharma Ltd. Bedford Labs Ben Venue Laboratories Inc. Boca Pharmacal Ben Venue Laboratories Inc. Actavis totowa llc Apotex inc etobicoke site Aurobindo pharma ltd Beijing double crane pharmaceutical co ltd Beijing yabao biopharmaceutical co ltd Advanced Pharmaceutical Services Inc. Amneal Pharmaceuticals Apotex Inc. Apotheca Inc. A-S Medication Solutions LLC Atlantic Biologicals Corporation Sandoz Allergy Laboratories Inc. Ben Venue Laboratories Inc.

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