About: Sulfisoxazole

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An Entity of Type : http://linked.opendata.cz/ontology/drugbank/Drug, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	http://linked.opendata.cz/ontology/drugbank/Drug
http://linked.open...gbank/description	A short-acting sulfonamide antibacterial with activity against a wide range of gram- negative and gram-positive organisms. [PubChem] (en)
http://linked.open...gy/drugbank/group	approved (en)
http://linked.open...ugbank/indication	For the treatment of severe, repeated, or long-lasting urinary tract infections, meningococcal meningitis, acute otitis media, trachoma, inclusion conjunctivitis, nocardiosis, chancroid, toxoplasmosis, malaria and other bacterial infections. (en)
http://linked.open...bank/manufacturer	APP Pharmaceuticals BASF Corp. Alra laboratories inc Brighton Pharmaceuticals Barr laboratories inc Bryant Ranch Prepack Caraco Pharmaceutical Labs Ivax pharmaceuticals inc sub teva pharmaceuticals usa Caremark LLC Comfortpak Inc. Corepharma LLC 4uOrtho LLC A-S Medication Solutions LLC Aidarex Pharmacuticals LLC Amend Anip Acquisition Co. A-S Medication Solutions LLC Aurobindo Pharma Ltd. Blenheim Pharmacal Boehringer Ingelheim Ltd.
sameAs	Sulfisoxazole Sulfisoxazole
Title	Sulfisoxazole (en)
adms:identifier	http://linked.opendata.cz/resource/drugbank/drug/DB00263/identifier/bindingdb/50034452 http://linked.opendata.cz/resource/drugbank/drug/DB00263/identifier/chebi/102484 http://linked.opendata.cz/resource/drugbank/drug/DB00263/identifier/chemspider/5151 http://linked.opendata.cz/resource/drugbank/drug/DB00263/identifier/drugbank/DB00263 http://linked.opendata.cz/resource/drugbank/drug/DB00263/identifier/kegg-compound/C07318 http://linked.opendata.cz/resource/drugbank/drug/DB00263/identifier/kegg-drug/D00450 http://linked.opendata.cz/resource/drugbank/drug/DB00263/identifier/national-drug-code-directory/0004-1003-28 http://linked.opendata.cz/resource/drugbank/drug/DB00263/identifier/pubchem-compound/5344 http://linked.opendata.cz/resource/drugbank/drug/DB00263/identifier/pubchem-substance/46505342 http://linked.opendata.cz/resource/drugbank/drug/DB00263/identifier/pharmgkb/PA164748964 http://linked.opendata.cz/resource/drugbank/drug/DB00263/identifier/wikipedia/Sulfisoxazole
http://linked.open...mechanismOfAction	Sulfisoxazole is a competitive inhibitor of the enzyme dihydropteroate synthetase. It inhibits bacterial synthesis of dihydrofolic acid by preventing the condensation of the pteridine with para-aminobenzoic acid (PABA), a substrate of the enzyme dihydropteroate synthetase. The inhibited reaction is necessary in these organisms for the synthesis of folic acid. (en)
http://linked.open...drugbank/packager	Amend Barr Pharmaceuticals Abbott Laboratories Ltd. Actavis Group AG Marin Pharmaceuticals Aidarex Pharmacuticals LLC Altura Pharmaceuticals Inc. Amerisource Health Services Corp. Amneal Pharmaceuticals Preferred Pharmaceuticals Inc. Apotheca Inc. A-S Medication Solutions LLC
http://linked.open...outeOfElimination	The mean urinary excretion recovery following oral administration of sulfisoxazole is 97% within 48 hours, of which 52% is intact drug, with the remaining as the N4-acetylated metabolite. It is excreted in human milk. (en)
http://linked.open.../drugbank/synonym	Sulfafurazole (en) Sulfadimethylisoxazole (en) Sulfafurazol (en) Sulfaisoxazole (en) Sulfasoxazole (en) Sulfisonazole (en) Sulfisoxasole (en) Sulfisoxazol (en) Sulfofurazole (en) Sulphafurazol (en) Sulphafurazole (en) Sulphaisoxazole (en) Sulphisoxazol (en) Sulphofurazole (en) 4-Amino-N-(3,4-dimethyl-5-isoxazolyl)benzenesulfonamide (en) 3,4-Dimethyl-5-sulfanilamidoisoxazole (en) 3,4-Dimethyl-5-sulfonamidoisoxazole (en) 3,4-Dimethyl-5-sulphanilamidoisoxazole (en) 3,4-Dimethyl-5-sulphonamidoisoxazole (en) 3,4-Dimethylisoxazole-5-sulfanilamide (en) 3,4-Dimethylisoxazole-5-sulphanilamide (en) 5-(4-Aminophenylsulfonamido)-3,4-dimethylisoxazole (en) 5-Sulfanilamido-3,4-dimethylisoxazole (en) 5-Sulphanilamido-3,4-dimethyl-isoxazole (en) 5-(P-Aminobenzenesulphonamido)-3,4-dimethylisoxazole (en) N'-(3,4)dimethylisoxazol-5-yl-sulphanilamide (en) N(1)-(3,4-Dimethyl-5-isoxazolyl)sulfanilamide (en) N(1)-(3,4-Dimethyl-5-isoxazolyl)sulphanilamide (en) Sulfafurazolum (en) Sulphadimethylisoxazole (en) 4-Amino-N-(3,4-dimethyl-5-isoxazolyl)benzenesulphonamide (en) 5-(P-Aminobenzenesulfonamido)-3,4-dimethylisoxazole (en)
http://linked.open...drugbank/toxicity	LD<sub>50</sub>=6800 mg/kg (Orally in mice) (en)
http://linked.open.../drug/hasAHFSCode	http://linked.opendata.cz/resource/AHFS/08-12-20
http://linked.open.../drugbank/mixture	Xodol ZAMICET
http://linked.open...ogy/drugbank/salt	(en)
http://linked.open...y/mesh/hasConcept	http://linked.opendata.cz/resource/mesh/concept/M0020779
foaf:page	http://www.drugs.com/mtm/sulfisoxazole-ophthalmic.html
http://linked.open...ugbank/IUPAC-Name	http://linked.opendata.cz/resource/drugbank/property/271B4266-363D-11E5-9242-09173F13E4C5
http://linked.open...gy/drugbank/InChI	http://linked.opendata.cz/resource/drugbank/property/271B426C-363D-11E5-9242-09173F13E4C5
http://linked.open...Molecular-Formula	http://linked.opendata.cz/resource/drugbank/property/271B426B-363D-11E5-9242-09173F13E4C5
http://linked.open.../Molecular-Weight	http://linked.opendata.cz/resource/drugbank/property/271B4268-363D-11E5-9242-09173F13E4C5
http://linked.open...noisotopic-Weight	http://linked.opendata.cz/resource/drugbank/property/271B4269-363D-11E5-9242-09173F13E4C5
http://linked.open...y/drugbank/SMILES	http://linked.opendata.cz/resource/drugbank/property/271B426A-363D-11E5-9242-09173F13E4C5
http://linked.open.../Water-Solubility	http://linked.opendata.cz/resource/drugbank/property/271B4264-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/property/271B427C-363D-11E5-9242-09173F13E4C5
http://linked.open...ogy/drugbank/logP	http://linked.opendata.cz/resource/drugbank/property/271B4262-363D-11E5-9242-09173F13E4C5

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