About: Lymecycline

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About: Lymecycline Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/drugbank/Drug, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	http://linked.opendata.cz/ontology/drugbank/Drug
http://linked.open...gbank/description	A tetracycline with a 7-chloro substitution. [PubChem] (en)
http://linked.open...generalReferences	# "Link":http://www.medsafe.govt.nz/profs/Datasheet/t/Tetralysalcap.htm # Meynadier J, Alirezai M: Systemic antibiotics for acne. Dermatology. 1998;196(1):135-9. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/9557248 (en)
http://linked.open...gy/drugbank/group	approved (en)
http://linked.open...ugbank/indication	For the treatment of infections and to treat acne. It may also be used to treat urinary tract infections, gum disease, and other bacterial infections such as gonorrhea and chlamydia. Lymecycline is also used commonly as a prophylactic treatment for infection by <i>Bacillus anthracis</i> (anthrax). It is also effective against <i>Yersinia pestis</i> and malaria and is also prescribed for the treatment of Lyme disease. (en)
http://linked.open...bank/manufacturer	Bioiberica Sa
sameAs	Lymecycline Lymecycline
Title	Lymecycline (en)
adms:identifier	http://linked.opendata.cz/resource/drugbank/drug/DB00256/identifier/chebi/59040 http://linked.opendata.cz/resource/drugbank/drug/DB00256/identifier/chemspider/23501197 http://linked.opendata.cz/resource/drugbank/drug/DB00256/identifier/drugbank/DB00256 http://linked.opendata.cz/resource/drugbank/drug/DB00256/identifier/kegg-drug/D06884 http://linked.opendata.cz/resource/drugbank/drug/DB00256/identifier/pdb/CTC http://linked.opendata.cz/resource/drugbank/drug/DB00256/identifier/pubchem-compound/24757945 http://linked.opendata.cz/resource/drugbank/drug/DB00256/identifier/pubchem-substance/46505518 http://linked.opendata.cz/resource/drugbank/drug/DB00256/identifier/pharmgkb/PA164747190 http://linked.opendata.cz/resource/drugbank/drug/DB00256/identifier/wikipedia/Lymecycline
http://linked.open...mechanismOfAction	Lymecycline inhibits cell growth by inhibiting translation. It binds to the 30S ribosomal subunit and prevents the amino-acyl tRNA from binding to the A site of the ribosome. The binding is reversible in nature. Lymecycline is lipophilic and can easily pass through the cell membrane or passively diffuses through porin channels in the bacterial membrane. Cells become resistant to lymecycline by at least two mechanisms: efflux and ribosomal protection. In efflux, a resistance gene encodes a membrane protein that actively pumps lymecycline out of the cell. This is the mechanism of action of the tetracycline resistance gene on the artificial plasmid pBR322. In ribosomal protection, a resistance gene encodes a protein which binds to the ribosome and prevents lymecycline from acting on the ribosome. (en)
http://linked.open...drugbank/packager	Baxter International Inc. Murfreesboro Pharmaceutical Nursing Supply
http://linked.open.../drugbank/synonym	N-Lysinomethyltetracycline (en) N6-((4-(Dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,6,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-2-naphthacenecarboxamido)methyl)lysine (en) Limeciclina (en) Lymecyclinum (en) Tetracycline-L-methylene lysine (en) Tetracycline-L-methylenelysine (en) N(2)-(((+)-5-Amino-5-carboxypentylamino)methyl)tetracycline (en) (+)-N-(5-Amino-5-carboxypentylaminomethyl)-4-dimethylamino-1,4,4a,5,5a,6,11,12a-octahydro-3,6,10,12,12a-pentahydroxy-6-methyl-1,11-dioxonaphthacene-2-carboxamide (en)
http://linked.open...drugbank/toxicity	Adverse effects include nausea, vomiting, diarrhoea, glossitis, enterocolitis, dysphagia, dermatitis, hypersensitivity reactions, proctitis, and vaginitis. (en)
http://linked.open...k/foodInteraction	Do not to take any indigestion remedies, iron or zinc supplements at the same time as this medicine. (en)
http://linked.open...ynthesisReference	Willis L. Winstrom, "Process and apparatus for the preparation of chlortetracycline-containing animal feed compositions." U.S. Patent US06844006, issued January 18, 2005. (en)
http://linked.open...y/mesh/hasConcept	http://linked.opendata.cz/resource/mesh/concept/M0012776
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http://linked.open...gy/drugbank/InChI	http://linked.opendata.cz/resource/drugbank/property/271B40B8-363D-11E5-9242-09173F13E4C5
http://linked.open...Molecular-Formula	http://linked.opendata.cz/resource/drugbank/property/271B40B7-363D-11E5-9242-09173F13E4C5
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http://linked.open...l/drug/hasATCCode	Lymecycline
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http://linked.open...ugbank/absorption	Absorption is fast and efficient. Bioavailability is 100% following oral administration. (en)
http://linked.open.../affectedOrganism	Enteric bacteria and other eubacteria (en)
http://linked.open...casRegistryNumber	992-21-2 (en)
http://linked.open...drugbank/category	(en)
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