About: Phenytoin

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An Entity of Type : http://linked.opendata.cz/ontology/drugbank/Drug, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	http://linked.opendata.cz/ontology/drugbank/Drug
http://linked.open...gbank/description	An anticonvulsant that is used in a wide variety of seizures. It is also an anti-arrhythmic and a muscle relaxant. The mechanism of therapeutic action is not clear, although several cellular actions have been described including effects on ion channels, active transport, and general membrane stabilization. The mechanism of its muscle relaxant effect appears to involve a reduction in the sensitivity of muscle spindles to stretch. Phenytoin has been proposed for several other therapeutic uses, but its use has been limited by its many adverse effects and interactions with other drugs. [PubChem] (en)
http://linked.open...y/drugbank/dosage	http://linked.opendata.cz/resource/drugbank/dosage/271B3F4A-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/dosage/271B3F4B-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/dosage/271B3F4C-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/dosage/271B3F4D-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/dosage/271B3F4E-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/dosage/271B3F4F-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/dosage/271B3F50-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/dosage/271B3F51-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/dosage/271B3F52-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/dosage/271B3F53-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/dosage/271B3F54-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/dosage/271B3F55-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/dosage/271B3F56-363D-11E5-9242-09173F13E4C5
http://linked.open...generalReferences	# https://www.pharmgkb.org/pathway/PA145011115 (en)
http://linked.open...gy/drugbank/group	approved (en)
http://linked.open...drugbank/halfLife	22 hours (range of 7 to 42 hours) (en)
http://linked.open...ugbank/indication	For the control of generalized tonic-clonic (grand mal) and complex partial (psychomotor, temporal lobe) seizures and prevention and treatment of seizures occurring during or following neurosurgery. (en)
http://linked.open...bank/manufacturer	Parke davis div warner lambert co Actavis mid atlantic llc APP Pharmaceuticals B. Braun Melsungen AG Baxter International Inc. Cardinal Health Lannett co inc Amneal pharmaceuticals ny llc Barr laboratories inc Mylan pharmaceuticals inc Pliva inc Sun pharmaceutical industries ltd Wockhardt ltd Dispensing Solutions Mylan Nucare Pharmaceuticals Inc. Ivax pharmaceuticals inc sub teva pharmaceuticals usa Physicians Total Care Inc. App pharmaceuticals llc Baxter healthcare corp American therapeutics inc Barr laboratories inc Marsam pharmaceuticals llc Novartis pharmaceuticals corp Sandoz inc Solopak medical products inc Vitarine pharmaceuticals inc
sameAs	Phenytoin Phenytoin
Title	Phenytoin (en)
adms:identifier	http://linked.opendata.cz/resource/drugbank/drug/DB00252/identifier/chebi/8107 http://linked.opendata.cz/resource/drugbank/drug/DB00252/identifier/chemspider/1710 http://linked.opendata.cz/resource/drugbank/drug/DB00252/identifier/drugbank/DB00252 http://linked.opendata.cz/resource/drugbank/drug/DB00252/identifier/guide-to-pharmacology/2624 http://linked.opendata.cz/resource/drugbank/drug/DB00252/identifier/iuphar/2624 http://linked.opendata.cz/resource/drugbank/drug/DB00252/identifier/kegg-compound/C07443 http://linked.opendata.cz/resource/drugbank/drug/DB00252/identifier/kegg-drug/D00512 http://linked.opendata.cz/resource/drugbank/drug/DB00252/identifier/national-drug-code-directory/51672-4069-1 http://linked.opendata.cz/resource/drugbank/drug/DB00252/identifier/pharmgkb/PA450947 http://linked.opendata.cz/resource/drugbank/drug/DB00252/identifier/pubchem-compound/1775 http://linked.opendata.cz/resource/drugbank/drug/DB00252/identifier/pubchem-substance/46508847 http://linked.opendata.cz/resource/drugbank/drug/DB00252/identifier/wikipedia/Phenytoin
http://linked.open...mechanismOfAction	Phenytoin acts on sodium channels on the neuronal cell membrane, limiting the spread of seizure activity and reducing seizure propagation. By promoting sodium efflux from neurons, phenytoin tends to stabilize the threshold against hyperexcitability caused by excessive stimulation or environmental changes capable of reducing membrane sodium gradient. This includes the reduction of post-tetanic potentiation at synapses. Loss of post-tetanic potentiation prevents cortical seizure foci from detonating adjacent cortical areas. (en)
http://linked.open...drugbank/packager	Actavis Group Amerisource Health Services Corp. Amneal Pharmaceuticals Apotheca Inc. A-S Medication Solutions LLC ALK-Abello Inc. Baxter International Inc. Medisca Inc. Bryant Ranch Prepack C.O. Truxton Inc. Caraco Pharmaceutical Labs Cardinal Health Carlisle Laboratories Inc. Pharmaceutical Utilization Management Program VA Inc. Coupler Enterprises Inc. Direct Dispensing Inc. Dispensing Solutions Akorn Inc. Baxter International Inc. F Hoffmann-La Roche Ltd. APP Pharmaceuticals Akorn inc Ebewe Pharma Hospira Inc. Lake Erie Medical and Surgical Supply Sandoz Medisca Inc. Murfreesboro Pharmaceutical Nursing Supply App pharmaceuticals llc Ebewe pharma ges mbh nfg kg Fresenius kabi oncology plc Hospira inc A-S Medication Solutions LLC Dispensing Solutions Pfizer Inc. Pfizer Inc. Lake Erie Medical and Surgical Supply Physicians Total Care Inc.

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