About: Terconazole     Goto   Sponge   NotDistinct   Permalink

An Entity of Type : http://linked.opendata.cz/ontology/drugbank/Drug, within Data Space : linked.opendata.cz associated with source document(s)

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  • Terconazole is an anti-fungal medication, primarily used to treat vaginal fungal infections. [Wikipedia] (en)
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  • approved (en)
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  • 6.9 hours (range 4.0-11.3) (en)
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  • For the treatment of candidiasis (a yeast-like fungal infection) of the vulva and vagina. (en)
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Title
  • Terconazole (en)
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  • Terconazole may exert its antifungal activity by disrupting normal fungal cell membrane permeability. Terconazole and other triazole antifungal agents inhibit cytochrome P450 14-alpha-demethylase in susceptible fungi, which leads to the accumulation of lanosterol and other methylated sterols and a decrease in ergosterol concentration. Depletion of ergosterol in the membrane disrupts the structure and function of the fungal cell leading to a decrease or inhibition of fungal growth. (en)
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  • Following oral (30 mg) administration of 14C-labelled terconazole, excretion of radioactivity was both by renal (32-56%) and fecal (47-52%) routes. (en)
http://linked.open.../drugbank/synonym
  • Terazol 3 (en)
http://linked.open...drugbank/toxicity
  • The oral LD<sub>50</sub> values were found to be 1741 and 849 mg/kg for the male and female in rat. (en)
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  • 94.9% (en)
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  • Following intravaginal administration of terconazole in humans, absorption ranged from 5-8% in three hysterectomized subjects and 12-16% in two non-hysterectomized subjects with tubal ligations (en)
http://linked.open.../affectedOrganism
  • Fungi (en)
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  • 67915-31-5 (en)
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  • (en)
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