About: Azithromycin

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An Entity of Type : http://linked.opendata.cz/ontology/drugbank/Drug, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	http://linked.opendata.cz/ontology/drugbank/Drug
http://linked.open...gbank/description	Azithromycin is a semi-synthetic macrolide antibiotic of the azalide class. Like other macrolide antibiotics, azithromycin inhibits bacterial protein synthesis by binding to the 50S ribosomal subunit of the bacterial 70S ribosome. Binding inhibits peptidyl transferase activity and interferes with amino acid translocation during the process of translation. Its effects may be bacteriostatic or bactericidal depending of the organism and the drug concentration. Its long half life, which enables once daily dosing and shorter administration durations, is a property distinct from other macrolides. (en)
http://linked.open...y/drugbank/dosage	http://linked.opendata.cz/resource/drugbank/dosage/271B5BD5-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/dosage/271B5BD6-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/dosage/271B5BD7-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/dosage/271B5BD8-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/dosage/271B5BD9-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/dosage/271B5BDA-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/dosage/271B5BDB-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/dosage/271B5BDC-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/dosage/271B5BDD-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/dosage/271B5BDE-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/dosage/271B5BDF-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/dosage/271B5BE0-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/dosage/271B5BE1-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/dosage/271B5BE2-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/dosage/271B5BE3-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/dosage/271B5BE4-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/dosage/271B5BE5-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/dosage/271B5BE6-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/dosage/271B5BE7-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/dosage/271B5BE8-363D-11E5-9242-09173F13E4C5
http://linked.open...generalReferences	# Noedl H, Krudsood S, Chalermratana K, Silachamroon U, Leowattana W, Tangpukdee N, Looareesuwan S, Miller RS, Fukuda M, Jongsakul K, Sriwichai S, Rowan J, Bhattacharyya H, Ohrt C, Knirsch C: Azithromycin combination therapy with artesunate or quinine for the treatment of uncomplicated Plasmodium falciparum malaria in adults: a randomized, phase 2 clinical trial in Thailand. Clin Infect Dis. 2006 Nov 15;43(10):1264-71. Epub 2006 Oct 12. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/17051490 (en)
http://linked.open...gy/drugbank/group	approved (en)
http://linked.open...drugbank/halfLife	68 hours (en)
http://linked.open...ugbank/indication	For the treatment of patients with mild to moderate infections caused by susceptible strains of the designated microorganisms in the specific conditions: <i>H. influenzae</i>, <i>M. catarrhalis</i>, <i>S. pneumoniae</i>, <i>C. pneumoniae</i>, <i>M. pneumoniae</i>, <i>S. pyogenes</i>, <i>S. aureus</i>, <i>S. agal</i> (en)
http://linked.open...bank/manufacturer	Akorn inc Alcon inc Alcon research ltd Bausch and lomb pharmaceuticals inc Sandoz canada inc Pfizer central research Allergan, Inc Gland pharma ltd Hospira inc Pliva hrvatska doo Sagent strides llc Teva parenteral medicines inc Pfizer inc Inspire pharmaceuticals inc Mylan pharmaceuticals inc Teva pharmaceuticals usa inc Amerisource Health Services Corp.
sameAs	Azithromycin Azithromycin
Title	Azithromycin (en)
adms:identifier	http://linked.opendata.cz/resource/drugbank/drug/DB00207/identifier/bindingdb/50197040 http://linked.opendata.cz/resource/drugbank/drug/DB00207/identifier/chebi/2955 http://linked.opendata.cz/resource/drugbank/drug/DB00207/identifier/drugbank/DB00207 http://linked.opendata.cz/resource/drugbank/drug/DB00207/identifier/kegg-compound/C06838 http://linked.opendata.cz/resource/drugbank/drug/DB00207/identifier/national-drug-code-directory/0069-3060-30 http://linked.opendata.cz/resource/drugbank/drug/DB00207/identifier/pdb/ZIT http://linked.opendata.cz/resource/drugbank/drug/DB00207/identifier/pharmgkb/PA448519 http://linked.opendata.cz/resource/drugbank/drug/DB00207/identifier/wikipedia/Azithromycin
http://linked.open...mechanismOfAction	Azithromycin binds to the 50S subunit of the 70S bacterial ribosomes, and therefore inhibits RNA-dependent protein synthesis in bacterial cells. (en)
http://linked.open...drugbank/packager	Aidarex Pharmacuticals LLC Amerisource Health Services Corp. Apotheca Inc. APP Pharmaceuticals AQ Pharmaceuticals Inc. A-S Medication Solutions LLC Baxter International Inc. APP Pharmaceuticals Baxter International Inc. C.O. Truxton Inc. Dept Health Central Pharmacy Pfizer Inc. Dispensing Solutions Sandoz Davis and geck div american cyanamid co Greenstone LLC H.J. Harkins Co. Inc. Hospira Inc. Innoviant Pharmacy Inc. Inspire Pharmaceuticals Kaiser Foundation Hospital Lake Erie Medical and Surgical Supply AAIPharma Inc. Actavis Group Amerisource Health Services Corp. Caraco Pharmaceutical Labs Cedar Pharmaceuticals LLC Centrix Pharmaceuticals Dispensing Solutions Eon Labs Heartland Repack Services LLC Pfizer Inc. Pharmaceutical Utilization Management Program VA Inc. AQ Pharmaceuticals Inc. Pharmaceutical Utilization Management Program VA Inc. Ivax pharmaceuticals inc sub teva pharmaceuticals usa Barr Pharmaceuticals Bristol-Myers Squibb Co. Dept Health Central Pharmacy Kaiser Foundation Hospital Murfreesboro Pharmaceutical Nursing Supply Mylan Physicians Total Care Inc. Prepak Systems Inc. Sandoz

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