About: Fluconazole

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An Entity of Type : http://linked.opendata.cz/ontology/drugbank/Drug, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	http://linked.opendata.cz/ontology/drugbank/Drug
http://linked.open...gbank/description	Triazole antifungal agent that is used to treat oropharyngeal candidiasis and cryptococcal meningitis in AIDS. [PubChem] (en)
http://linked.open...y/drugbank/dosage	http://linked.opendata.cz/resource/drugbank/dosage/271B57C2-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/dosage/271B57C3-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/dosage/271B57C4-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/dosage/271B57C5-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/dosage/271B57C6-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/dosage/271B57C7-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/dosage/271B57C8-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/dosage/271B57C9-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/dosage/271B57CA-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/dosage/271B57CB-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/dosage/271B57CC-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/dosage/271B57CD-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/dosage/271B57CE-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/dosage/271B57CF-363D-11E5-9242-09173F13E4C5
http://linked.open...gy/drugbank/group	approved (en)
http://linked.open...drugbank/halfLife	30 hours (range 20-50 hours) (en)
http://linked.open...ugbank/indication	For the treatment of fungal infections. (en)
http://linked.open...bank/manufacturer	Pfizer chemicals div pfizer inc Aurobindo pharma usa inc Ivax pharmaceuticals inc sub teva pharmaceuticals usa Bausch & Lomb Inc. Dispensing Solutions Taro pharmaceutical industries ltd Falcon Pharmaceuticals Ltd. Acs dobfar info sa Apotex inc richmond hill Hospira inc App pharmaceuticals llc Bedford laboratories div ben venue laboratories inc Claris lifesciences ltd Hikma farmaceutica portugal lda Teva parenteral medicines inc Baxter healthcare corp Bedford laboratories Pfizer central research Apotex inc Aurobindo pharma ltd Apotheca Inc. A-S Medication Solutions LLC Bryant Ranch Prepack C.O. Truxton Inc. AAIPharma Inc. Abbott Laboratories Ltd. Actavis Group Advanced Pharmaceutical Services Inc. Aidarex Pharmacuticals LLC
sameAs	Fluconazole Fluconazole
Title	Fluconazole (en)
adms:identifier	http://linked.opendata.cz/resource/drugbank/drug/DB00196/identifier/bindingdb/25817 http://linked.opendata.cz/resource/drugbank/drug/DB00196/identifier/chebi/46081 http://linked.opendata.cz/resource/drugbank/drug/DB00196/identifier/chemspider/3248 http://linked.opendata.cz/resource/drugbank/drug/DB00196/identifier/drugbank/DB00196 http://linked.opendata.cz/resource/drugbank/drug/DB00196/identifier/kegg-drug/D00322 http://linked.opendata.cz/resource/drugbank/drug/DB00196/identifier/national-drug-code-directory/0054-0002-85 http://linked.opendata.cz/resource/drugbank/drug/DB00196/identifier/pdb/TPF http://linked.opendata.cz/resource/drugbank/drug/DB00196/identifier/pharmgkb/PA449653 http://linked.opendata.cz/resource/drugbank/drug/DB00196/identifier/pubchem-compound/3365 http://linked.opendata.cz/resource/drugbank/drug/DB00196/identifier/pubchem-substance/46505735 http://linked.opendata.cz/resource/drugbank/drug/DB00196/identifier/wikipedia/Fluconazole
http://linked.open...mechanismOfAction	Fluconazole interacts with 14-α demethylase, a cytochrome P-450 enzyme necessary to convert lanosterol to ergosterol. As ergosterol is an essential component of the fungal cell membrane, inhibition of its synthesis results in increased cellular permeability causing leakage of cellular contents. Fluconazole may also inhibit endogenous respiration, interact with membrane phospholipids, inhibit the transformation of yeasts to mycelial forms, inhibit purine uptake, and impair triglyceride and/or phospholipid biosynthesis. (en)
http://linked.open...drugbank/packager	Advanced Pharmaceutical Services Inc. Amerisource Health Services Corp. Apotex Inc. Apotheca Inc. APP Pharmaceuticals AQ Pharmaceuticals Inc. A-S Medication Solutions LLC Atlantic Biologicals Corporation Aurobindo Pharma Ltd. Baxter International Inc. Bedford Labs Ben Venue Laboratories Inc. Bryant Ranch Prepack Cardinal Health Biovail laboratories inc Mutual pharmaceutical co inc Par pharmaceutical inc Sandoz inc Superpharm corp Ar holding co inc 3M Health Care Apotex Inc. A-S Medication Solutions LLC Abbott Laboratories Ltd. Alliance Medical Products Ben Venue Laboratories Inc. Ivax pharmaceuticals inc sub teva pharmaceuticals usa Catalent Pharma Solutions Cipla Ltd. Cobalt Pharmaceuticals Inc. Dey Pharma LP Dispensing Solutions Diversified Healthcare Services Inc. Sandoz Holopack International Corp. Actavis elizabeth llc Apotex inc etobicoke site

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