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rdf:type
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http://linked.open...gbank/description
| - A cardioselective beta-1-adrenergic antagonist with no partial agonist activity. [PubChem] (en)
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http://linked.open...y/drugbank/dosage
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http://linked.open...generalReferences
| - # Canotilho J, Castro RA: The structure of betaxolol studied by infrared spectroscopy and natural bond orbital theory. Spectrochim Acta A Mol Biomol Spectrosc. 2010 Aug;76(3-4):395-400. Epub 2010 Apr 4. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/20418154 (en)
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http://linked.open...gy/drugbank/group
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http://linked.open...drugbank/halfLife
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http://linked.open...ugbank/indication
| - For the management of hypertension. (en)
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http://linked.open...bank/manufacturer
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sameAs
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Title
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adms:identifier
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http://linked.open...mechanismOfAction
| - Betaxolol selectively blocks catecholamine stimulation of beta(1)-adrenergic receptors in the heart and vascular smooth muscle. This results in a reduction of heart rate, cardiac output, systolic and diastolic blood pressure, and possibly reflex orthostatic hypotension. Betaxolol can also competitively block beta(2)-adrenergic responses in the bronchial and vascular smooth muscles, causing bronchospasm. (en)
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http://linked.open...drugbank/packager
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http://linked.open...y/drugbank/patent
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http://linked.open.../drugbank/synonym
| - Betaxololum (en)
- 1-(Isopropylamino)-3-[P-(cyclopropylmethoxyethyl)phenoxy]-2-propanol (en)
- 1-(4-(2-(Cyclopropylmethoxy)ethyl)phenoxy)-3-((1-methylethyl)amino)-2-propanol (en)
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http://linked.open...drugbank/toxicity
| - Oral LD<sub>50</sub>s are 350 to 400 mg betaxolol/kg in mice and 860 to 980 mg/kg in rats. Predicted symptoms of overdose include bradycardia, congestive heart failure, hypotension, bronchospasm, and hypoglycemia. (en)
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http://linked.open.../drug/hasAHFSCode
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http://linked.open...nk/proteinBinding
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http://linked.open...ogy/drugbank/salt
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http://linked.open...ynthesisReference
| - Ramesh Joshi, Muthukrishnan Murugan, Dinesh Garud, Sanjay Borikar, Mukund Gurjar, "PROCESS FOR PREPARATION OF S-(-)-BETAXOLOL AND SALTS THEREOF." U.S. Patent US20060004109, issued January 05, 2006. (en)
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http://linked.open...y/mesh/hasConcept
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foaf:page
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http://linked.open...ugbank/IUPAC-Name
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http://linked.open...gy/drugbank/InChI
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http://linked.open...Molecular-Formula
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http://linked.open.../Molecular-Weight
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http://linked.open...noisotopic-Weight
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http://linked.open...y/drugbank/SMILES
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http://linked.open.../Water-Solubility
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http://linked.open...ogy/drugbank/logP
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http://linked.open...ogy/drugbank/logS
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http://linked.open...logy/drugbank/pKa
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http://linked.open...l/drug/hasATCCode
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http://linked.open...nd-Acceptor-Count
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http://linked.open...-Bond-Donor-Count
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http://linked.open...drugbank/InChIKey
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http://linked.open...urface-Area--PSA-
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http://linked.open...nk/Polarizability
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http://linked.open...bank/Refractivity
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http://linked.open...atable-Bond-Count
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http://linked.open...ugbank/absorption
| - Absorption of an oral dose is complete. There is a small and consistent first-pass effect resulting in an absolute bioavailability of 89% ± 5% that is unaffected by the concomitant ingestion of food or alcohol. (en)
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http://linked.open.../affectedOrganism
| - Humans and other mammals (en)
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http://linked.open...aco2-Permeability
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http://linked.open...casRegistryNumber
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http://linked.open...drugbank/category
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http://linked.open...gbank/containedIn
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