About: Baclofen

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An Entity of Type : http://linked.opendata.cz/ontology/drugbank/Drug, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	http://linked.opendata.cz/ontology/drugbank/Drug
http://linked.open...gbank/description	Baclofen is a gamma-amino-butyric acid (GABA) derivative used as a skeletal muscle relaxant. Baclofen stimulates GABA-B receptors leading to decreased frequency and amplitude of muscle spasms. It is especially useful in treating muscle spasticity associated with spinal cord injury. It appears to act primarily at the spinal cord level by inhibiting spinal polysynaptic afferent pathways and, to a lesser extent, monosynaptic afferent pathways. (en)
http://linked.open...y/drugbank/dosage	http://linked.opendata.cz/resource/drugbank/dosage/271B5359-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/dosage/271B535A-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/dosage/271B535B-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/dosage/271B535C-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/dosage/271B535D-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/dosage/271B535E-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/dosage/271B535F-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/dosage/271B5360-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/dosage/271B5361-363D-11E5-9242-09173F13E4C5
http://linked.open...generalReferences	# Dzitoyeva S, Dimitrijevic N, Manev H: Gamma-aminobutyric acid B receptor 1 mediates behavior-impairing actions of alcohol in Drosophila: adult RNA interference and pharmacological evidence. Proc Natl Acad Sci U S A. 2003 Apr 29;100(9):5485-90. Epub 2003 Apr 11. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/12692303 # Mezler M, Muller T, Raming K: Cloning and functional expression of GABA(B) receptors from Drosophila. Eur J Neurosci. 2001 Feb;13(3):477-86. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/11168554 # See S, Ginzburg R: Skeletal muscle relaxants. Pharmacotherapy. 2008 Feb;28(2):207-13. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/18225966 (en)
http://linked.open...gy/drugbank/group	approved (en)
http://linked.open...drugbank/halfLife	2.5-4 hours (en)
http://linked.open...ugbank/indication	For the alleviation of signs and symptoms of spasticity resulting from multiple sclerosis, particularly for the relief of flexor spasms and concomitant pain, clonus, and muscular rigidity. (en)
http://linked.open...bank/manufacturer	Medtronic inc Schwarz pharma inc Actavis totowa llc Caraco pharmaceutical laboratories ltd Claris lifesciences ltd Ivax pharmaceuticals inc sub teva pharmaceuticals usa Lannett holdings inc Matrix laboratories ltd Mylan pharmaceuticals inc Northstar healthcare holdings ltd Ivax pharmaceuticals inc sub teva pharmaceuticals usa Mutual pharmaceutical co inc Sandoz inc Teva pharmaceuticals usa inc Novartis pharmaceuticals corp
sameAs	Baclofen Baclofen
Title	Baclofen (en)
adms:identifier	http://linked.opendata.cz/resource/drugbank/drug/DB00181/identifier/bindingdb/24182 http://linked.opendata.cz/resource/drugbank/drug/DB00181/identifier/chebi/2972 http://linked.opendata.cz/resource/drugbank/drug/DB00181/identifier/chemspider/2197 http://linked.opendata.cz/resource/drugbank/drug/DB00181/identifier/drugbank/DB00181 http://linked.opendata.cz/resource/drugbank/drug/DB00181/identifier/guide-to-pharmacology/1084 http://linked.opendata.cz/resource/drugbank/drug/DB00181/identifier/iuphar/1084 http://linked.opendata.cz/resource/drugbank/drug/DB00181/identifier/kegg-drug/D00241 http://linked.opendata.cz/resource/drugbank/drug/DB00181/identifier/national-drug-code-directory/0091-3351-01 http://linked.opendata.cz/resource/drugbank/drug/DB00181/identifier/pharmgkb/PA448533 http://linked.opendata.cz/resource/drugbank/drug/DB00181/identifier/pubchem-compound/2284 http://linked.opendata.cz/resource/drugbank/drug/DB00181/identifier/pubchem-substance/46508181 http://linked.opendata.cz/resource/drugbank/drug/DB00181/identifier/wikipedia/Baclofen
http://linked.open...mechanismOfAction	Baclofen is a direct agonist at GABAB receptors. The precise mechanism of action of Baclofen is not fully known. It is capable of inhibiting both monosynaptic and polysynaptic reflexes at the spinal level, possibly by hyperpolarization of afferent terminals, although actions at supraspinal sites may also occur and contribute to its clinical effect. (en)
http://linked.open...drugbank/packager	Comprehensive Consultant Services Inc. Diversified Healthcare Services Inc. Eon Labs Goldline Laboratories Inc. Heartland Repack Services LLC Hospira Inc. Ivax Pharmaceuticals Kaiser Foundation Hospital Major Pharmaceuticals Mckesson Corp. Murfreesboro Pharmaceutical Nursing Supply 3M Health Care Alphapharm Party Ltd. Amneal Pharmaceuticals Pharmaceutical Utilization Management Program VA Inc. APPD Baxter International Inc. Hospira Inc. Murfreesboro Pharmaceutical Nursing Supply App pharmaceuticals llc Armour pharmaceutical co Baxter healthcare corp anesthesia and critical care Pharmaceutical Utilization Management Program VA Inc. Physicians Total Care Inc. Ranbaxy Laboratories Actavis Group Advanced Pharmaceutical Services Inc. Aidarex Pharmacuticals LLC Alphapharm Party Ltd. Sandoz Alcon Laboratories A-S Medication Solutions LLC Apotex inc Bausch and lomb inc Cardinal Health Caremark LLC Comprehensive Consultant Services Inc. Corepharma LLC Direct Dispensing Inc. Dispensing Solutions Diversified Healthcare Services Inc. Genpharm LP Heartland Repack Services LLC Akorn Inc. Ivax Pharmaceuticals Keltman Pharmaceuticals Inc. Lake Erie Medical and Surgical Supply Akorn Inc. Amerisource Health Services Corp. Apotex Inc. Baxter International Inc. Bedford Labs Ben Venue Laboratories Inc. Cardinal Health

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