About: Lipoic Acid

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About: Lipoic Acid Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/drugbank/Drug, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	http://linked.opendata.cz/ontology/drugbank/Drug
http://linked.open...gbank/description	A vitamin-like antioxidant. [PubChem] (en)
http://linked.open...generalReferences	# Perham RN: Swinging arms and swinging domains in multifunctional enzymes: catalytic machines for multistep reactions. Annu Rev Biochem. 2000;69:961-1004. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/10966480 # REED LJ, DeBUSK BG, GUNSALUS IC, HORNBERGER CS Jr: Crystalline alpha-lipoic acid; a catalytic agent associated with pyruvate dehydrogenase. Science. 1951 Jul 27;114(2952):93-4. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/14854913 (en)
http://linked.open...gy/drugbank/group	approved (en) nutraceutical (en)
http://linked.open...ugbank/indication	For nutritional supplementation, also for treating dietary shortage or imbalance. (en)
sameAs	Lipoic Acid Lipoic Acid
Title	Lipoic Acid (en)
adms:identifier	http://linked.opendata.cz/resource/drugbank/drug/DB00166/identifier/chebi/16494 http://linked.opendata.cz/resource/drugbank/drug/DB00166/identifier/drugbank/DB00166 http://linked.opendata.cz/resource/drugbank/drug/DB00166/identifier/kegg-compound/C00725 http://linked.opendata.cz/resource/drugbank/drug/DB00166/identifier/kegg-drug/D00086 http://linked.opendata.cz/resource/drugbank/drug/DB00166/identifier/pdb/LPA http://linked.opendata.cz/resource/drugbank/drug/DB00166/identifier/pharmgkb/PA164776929 http://linked.opendata.cz/resource/drugbank/drug/DB00166/identifier/wikipedia/Lipoic_Acid
http://linked.open...mechanismOfAction	Lipoic Acid is generally involved in oxidative decarboxylations of keto acids and is presented as a growth factor for some organisms. Lipoic acid exists as two enantiomers, the R-enantiomer and the S-enantiomer. Normally only the R-enantiomer of an amino acid is biologically active, but for lipoic acid the S-enantiomer assists in the reduction of the R-enantiomer when a racemic mixture is given. Some recent studies have suggested that the S-enantiomer in fact has an inhibiting effect on the R-enantiomer, reducing its biological activity substantially and actually adding to oxidative stress rather than reducing it. Furthermore, the S-enantiomer has been found to reduce the expression of GLUT-4s in cells, responsible for glucose uptake, and hence reduce insulin sensitivity. (en)
http://linked.open...drugbank/packager	Bausch & Lomb Inc. Barr laboratories inc Biovail Pharmaceuticals Bryant Ranch Prepack Cardinal Health
http://linked.open.../drugbank/synonym	Biletan (en) Thioctic acid (en) alpha-Lipoic acid (en) 1,2-dithiolane-3-pentanoic acid (en) 1,2-dithiolane-3-valeric acid (en) 5-(1,2-dithiolan-3-yl)valeric acid (en) 5-(dithiolan-3-yl)valeric acid (en) 5-[3-(1,2-dithiolanyl)]pentanoic acid (en) 6,8-thioctic acid (en) 6,8-thiotic acid (en) 6-thioctic acid (en) 6-thiotic acid (en) Acetate-replacing factor (en) Lipoic acid (en) Thioctansaeure (en) Thioctsaeure (en) Thioktsaeure (en) alpha-Liponsaeure (en) liponic acid (en) α-lipoic acid (en)
http://linked.open...ynthesisReference	Joachim Paust, Peter Eckes, Wolfgang Siegel, Friedhelm Balkenhohl, Walter Dobler, Michael Hullmann, "Preparation of R/S-.gamma.-lipoic acid or R/S-.alpha.-lipoic acid." U.S. Patent US5489694, issued July, 1961. (en)
http://linked.open...y/mesh/hasConcept	http://linked.opendata.cz/resource/mesh/concept/M0012565
http://linked.open...ugbank/IUPAC-Name	http://linked.opendata.cz/resource/drugbank/property/271B4FBC-363D-11E5-9242-09173F13E4C5
http://linked.open...gy/drugbank/InChI	http://linked.opendata.cz/resource/drugbank/property/271B4FC2-363D-11E5-9242-09173F13E4C5
http://linked.open...Molecular-Formula	http://linked.opendata.cz/resource/drugbank/property/271B4FC1-363D-11E5-9242-09173F13E4C5
http://linked.open.../Molecular-Weight	http://linked.opendata.cz/resource/drugbank/property/271B4FBE-363D-11E5-9242-09173F13E4C5
http://linked.open...noisotopic-Weight	http://linked.opendata.cz/resource/drugbank/property/271B4FBF-363D-11E5-9242-09173F13E4C5
http://linked.open...y/drugbank/SMILES	http://linked.opendata.cz/resource/drugbank/property/271B4FC0-363D-11E5-9242-09173F13E4C5
http://linked.open.../Water-Solubility	http://linked.opendata.cz/resource/drugbank/property/271B4FBA-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/property/271B4FD1-363D-11E5-9242-09173F13E4C5
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http://linked.open...ogy/drugbank/logS	http://linked.opendata.cz/resource/drugbank/property/271B4FB9-363D-11E5-9242-09173F13E4C5
http://linked.open...l/drug/hasATCCode	Thioctic acid
http://linked.open...nd-Acceptor-Count	http://linked.opendata.cz/resource/drugbank/property/271B4FC8-363D-11E5-9242-09173F13E4C5
http://linked.open...-Bond-Donor-Count	http://linked.opendata.cz/resource/drugbank/property/271B4FC9-363D-11E5-9242-09173F13E4C5
http://linked.open...drugbank/InChIKey	http://linked.opendata.cz/resource/drugbank/property/271B4FC3-363D-11E5-9242-09173F13E4C5
http://linked.open...urface-Area--PSA-	http://linked.opendata.cz/resource/drugbank/property/271B4FC4-363D-11E5-9242-09173F13E4C5
http://linked.open...nk/Polarizability	http://linked.opendata.cz/resource/drugbank/property/271B4FC6-363D-11E5-9242-09173F13E4C5
http://linked.open...bank/Refractivity	http://linked.opendata.cz/resource/drugbank/property/271B4FC5-363D-11E5-9242-09173F13E4C5
http://linked.open...atable-Bond-Count	http://linked.opendata.cz/resource/drugbank/property/271B4FC7-363D-11E5-9242-09173F13E4C5
http://linked.open.../affectedOrganism	Humans and other mammals (en)
http://linked.open...casRegistryNumber	62-46-4 (en)
http://linked.open...drugbank/category	(en)
http://linked.open...gbank/containedIn	Lipoic acid powder Alpha-lipoic acid 50 mg caplet Alpha lipoic acid 200 mg tablet Hydroxyurea 500 mg capsule
http://linked.open...k/Bioavailability	http://linked.opendata.cz/resource/drugbank/property/271B4FCD-363D-11E5-9242-09173F13E4C5
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http://linked.open...ank/Melting-Point	http://linked.opendata.cz/resource/drugbank/property/271B4FD2-363D-11E5-9242-09173F13E4C5
http://linked.open...k/Number-of-Rings	http://linked.opendata.cz/resource/drugbank/property/271B4FCC-363D-11E5-9242-09173F13E4C5
http://linked.open...siological-Charge	http://linked.opendata.cz/resource/drugbank/property/271B4FCB-363D-11E5-9242-09173F13E4C5
http://linked.open...bank/Rule-of-Five	http://linked.opendata.cz/resource/drugbank/property/271B4FCE-363D-11E5-9242-09173F13E4C5
http://linked.open...tional-IUPAC-Name	http://linked.opendata.cz/resource/drugbank/property/271B4FBD-363D-11E5-9242-09173F13E4C5
http://linked.open...strongest-acidic-	http://linked.opendata.cz/resource/drugbank/property/271B4FCA-363D-11E5-9242-09173F13E4C5

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