About: Ergocalciferol

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An Entity of Type : http://linked.opendata.cz/ontology/drugbank/Drug, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	http://linked.opendata.cz/ontology/drugbank/Drug
http://linked.open...gbank/description	Ergocalciferol (Vitamin D2) is a derivative of ergosterol formed by ultraviolet rays breaking of the C9-C10 bond. It differs from cholecalciferol in having a double bond between C22 and C23 and a methyl group at C24. [PubChem] (en)
http://linked.open...y/drugbank/dosage	http://linked.opendata.cz/resource/drugbank/dosage/271B4CC4-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/dosage/271B4CC5-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/dosage/271B4CC6-363D-11E5-9242-09173F13E4C5
http://linked.open...generalReferences	# DeLuca HF: Overview of general physiologic features and functions of vitamin D. Am J Clin Nutr. 2004 Dec;80(6 Suppl):1689S-96S. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/15585789 (en)
http://linked.open...gy/drugbank/group	approved (en) nutraceutical (en)
http://linked.open...drugbank/halfLife	19 to 48 hours (however, stored in fat deposits in body for prolonged periods). (en)
http://linked.open...ugbank/indication	For use in the management of hypocalcemia and its clinical manifestations in patients with hypoparathyroidism, as well as for the treatment of familial hypophosphatemia (vitamin D resistant rickets). This drug has also been used in the treatment of nutritional rickets or osteomalacia, vitamin D dependent rickets, rickets or osteomalacia secondary to long-term high dose anticonvulsant therapy, early renal osteodystrophy, osteoporosis (in conjunction with calcium), and hypophosphatemia associated with Fanconi syndrome (with treatment of acidosis). (en)
http://linked.open...bank/manufacturer	Eli lilly and co App pharmaceuticals llc Orit laboratories llc Pharmachemie bv Strides arcolab ltd Bristol myers squibb co Banner pharmacaps inc Chase chemical co lp Everylife Impax laboratories inc Lannett co inc Vitarine pharmaceuticals inc West ward pharmaceutical corp
sameAs	Ergocalciferol Ergocalciferol
Title	Ergocalciferol (en)
adms:identifier	http://linked.opendata.cz/resource/drugbank/drug/DB00153/identifier/chebi/28934 http://linked.opendata.cz/resource/drugbank/drug/DB00153/identifier/chemspider/4444351 http://linked.opendata.cz/resource/drugbank/drug/DB00153/identifier/drugbank/DB00153 http://linked.opendata.cz/resource/drugbank/drug/DB00153/identifier/kegg-compound/C05441 http://linked.opendata.cz/resource/drugbank/drug/DB00153/identifier/kegg-drug/D00187 http://linked.opendata.cz/resource/drugbank/drug/DB00153/identifier/national-drug-code-directory/51991-604-01 http://linked.opendata.cz/resource/drugbank/drug/DB00153/identifier/pharmgkb/PA449484 http://linked.opendata.cz/resource/drugbank/drug/DB00153/identifier/pubchem-compound/5280793 http://linked.opendata.cz/resource/drugbank/drug/DB00153/identifier/pubchem-substance/46505053 http://linked.opendata.cz/resource/drugbank/drug/DB00153/identifier/wikipedia/Ergocalciferol
http://linked.open...mechanismOfAction	Activated ergocalciferol increases serum calcium and phosphate concentrations, primarily by increasing intestinal absorption of calcium and phosphate through binding to a specific receptor in the mucosal cytoplasm of the intestine. Subsequently, calcium is absorbed through formation of a calcium-binding protein. 25-hydroxyergocalciferol is the intermediary metabolite of ergocalciferol. Although this metabolite exhibits 2–5 times more activity than unactivated ergocalciferol in curing rickets and inducing calcium absorption and mobilization (from bone) in animals, this increased activity is still insufficient to affect these functions at physiologic concentrations. Activated ergocalciferol stimulate resorption of bone and are required for normal mineralization of bone. Physiological doses of ergocalciferol also promotes calcium reabsorption by the kidneys, but the significance of this effect is not known. (en)
http://linked.open...drugbank/packager	Alza Corp. APP Pharmaceuticals APPD Baxter International Inc. Bedford Labs Ben Venue Laboratories Inc. Bristol-Myers Squibb Co. Centocor Ortho Biotech Inc. Mead Johnson and Co. Pfizer Inc. Alliant Pharmaceuticals Inc. Apotheca Inc. Century Pharmaceuticals Inc. Dept Health Central Pharmacy Dispensing Solutions Major Pharmaceuticals
http://linked.open.../drugbank/synonym	Ergocalciferol (en) Calciferol (en) Ercalciol (en) Oleovitamin D2 (en) Viosterol (en) Vitamin D2 (en) (5Z,7e,22e)-(3S)-9,10-Seco-5,7,10(19),22-ergostatetraen-3-ol (en) Activated ergosterol (en) Ergocalciferolum (en) Vitamina D2 (en) (5Z,7e,22e)-(3S)-9,10-Secoergosta-5,7,10(19),22-tetraen-3-ol (en) (3beta,5Z,7e,22e)-9,10-Secoergosta-5,7,10(19),22-tetraen-3-ol (en)
http://linked.open...drugbank/toxicity	LD<sub>50</sub> = 23.7 mg/kg (Orally in mice); LD<sub>50</sub> = 10 mg/kg (Orally in rats ); Nausea, vomiting and diarrhea, weight loss, irritability, weakness, fatigue, lassitude, and headache. (en)
http://linked.open.../drugbank/mixture	Pro-Lyte Calcium and Magnesium Citrate with Vitamin D Calcium Magnesium 2:1 Tablets with Vitamin D Centrum 8409 Insur-All Vitamin Supplement Mega Halibut Liver Oil Msb Essentials Pre-Natal Super Thera-M Timed Release Multi Vitamin with Chelated Minerals
http://linked.open...nk/proteinBinding	>99.8% (en)
http://linked.open...ynthesisReference	Charles W. Bishop, Glenville Jones, Ronald L. Horst, Nicholas J. Koszewski, Joyce C. Knutson, Raju Penmasta, Robert M. Moriarty, Stephen Strugnell, Timothy A. Reinhardt, Liang Guo, Sanjay K. Singhal, Lei Zhao, "Methods for preparation and use of 1A,24(S)-dihydroxy vitamin D2." U.S. Patent US5789397, issued March, 1992. (en)
http://linked.open...y/mesh/hasConcept	http://linked.opendata.cz/resource/mesh/concept/M0007650
foaf:page	http://www.drugs.com/cdi/ergocalciferol.html http://www.pdrhealth.com/drug_info/nmdrugprofiles/nutsupdrugs/vit_0265.shtml http://www.rxlist.com/cgi/generic/ergocalciferol.htm
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http://linked.open...l/drug/hasATCCode	Ergocalciferol
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