About: L-Cysteine

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An Entity of Type : http://linked.opendata.cz/ontology/drugbank/Drug, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	http://linked.opendata.cz/ontology/drugbank/Drug
http://linked.open...gbank/description	A thiol-containing non-essential amino acid that is oxidized to form cystine. [PubChem] (en)
http://linked.open...generalReferences	# Bulaj G, Kortemme T, Goldenberg DP: Ionization-reactivity relationships for cysteine thiols in polypeptides. Biochemistry. 1998 Jun 23;37(25):8965-72. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/9636038 # Baker DH, Czarnecki-Maulden GL: Pharmacologic role of cysteine in ameliorating or exacerbating mineral toxicities. J Nutr. 1987 Jun;117(6):1003-10. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/3298579 (en)
http://linked.open...gy/drugbank/group	approved (en) nutraceutical (en)
http://linked.open...ugbank/indication	For the prevention of liver damage and kidney damage associated with overdoses of acetaminophen (en)
http://linked.open...bank/manufacturer	Actavis Group
sameAs	L-Cysteine L-Cysteine
Title	L-Cysteine (en)
adms:identifier	http://linked.opendata.cz/resource/drugbank/drug/DB00151/identifier/chebi/17561 http://linked.opendata.cz/resource/drugbank/drug/DB00151/identifier/drugbank/DB00151 http://linked.opendata.cz/resource/drugbank/drug/DB00151/identifier/kegg-compound/C00097 http://linked.opendata.cz/resource/drugbank/drug/DB00151/identifier/kegg-drug/D00026 http://linked.opendata.cz/resource/drugbank/drug/DB00151/identifier/pdb/CYS http://linked.opendata.cz/resource/drugbank/drug/DB00151/identifier/pharmgkb/PA449173 http://linked.opendata.cz/resource/drugbank/drug/DB00151/identifier/wikipedia/L-Cysteine
http://linked.open...mechanismOfAction	Although classified as a non-essential amino acid cysteine may be essential for infants, the elderly, and individuals with certain metabolic disease or who suffer from malabsorption syndromes. Cysteine can usually be synthesized by the human body under normal physiological conditions if a sufficient quantity of methionine is available. Due to the ability of thiols to undergo redox reactions, cysteine has antioxidant properties. Cysteine's antioxidant properties are typically expressed in the tripeptide glutathione, which occurs in humans as well as other organisms. The systemic availability of oral glutathione (GSH) is negligible; so it must be biosynthesized from its constituent amino acids, cysteine, glycine, and glutamic acid. Glutamic acid and glycine are readily available in the diets of most industrialized countries, but the availability of cysteine can be the limiting substrate. Cysteine is also an important source of sulfide in human metabolism. The sulfide in iron-sulfur clusters and in nitrogenase is extracted from cysteine, which is converted to alanine in the process. In a 1994 report released by five top cigarette companies, cysteine is one of the 599 additives to cigarettes. Its use or purpose, however, is unknown, like most cigarette additives. Its inclusion in cigarettes could offer two benefits: Acting as an expectorant, since smoking increases mucus production in the lungs; and increasing the beneficial antioxidant glutathione (which is diminished in smokers). (en)
http://linked.open...drugbank/packager	Amend Ivax pharmaceuticals inc sub teva pharmaceuticals usa 4uOrtho LLC
http://linked.open.../drugbank/synonym	(R)-2-Amino-3-mercaptopropanoic acid (en) Cys (en) L-2-Amino-3-mercaptopropionic acid (en) L-Cys (en) (2R)-2-amino-3-mercaptopropanoic acid (en) (2R)-2-amino-3-sulfanylpropanoic acid (en)
http://linked.open.../drugbank/mixture	Amino Acid Concentrate Inj Amino Acid Inj Amino Lite Aminoderm Poudre Bvs Amino Acid Solution Inj Cicatrin Powder Nephramine Liq Iv Primene 10% Primene 10%-Liq Iv Stv Amino Acid Sol Inj Vamin 18 Electrolyte-Free Vamin N
http://linked.open...ynthesisReference	Alfred Maierhofer, Hans Wagner, "Process for the production of high purity S-carboxymethyl-L-cysteine." U.S. Patent US4129593, issued May, 1965. (en)
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http://linked.open...gy/drugbank/InChI	http://linked.opendata.cz/resource/drugbank/property/271B4C09-363D-11E5-9242-09173F13E4C5
http://linked.open...Molecular-Formula	http://linked.opendata.cz/resource/drugbank/property/271B4C08-363D-11E5-9242-09173F13E4C5
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http://linked.open.../affectedOrganism	Humans and other mammals (en)
http://linked.open...casRegistryNumber	52-90-4 (en)
http://linked.open...drugbank/category	(en)
http://linked.open...gbank/containedIn	L-cysteine powder L-cysteine hcl powder Fenoprofen Calcium 600 mg tablet
http://linked.open...k/Bioavailability	http://linked.opendata.cz/resource/drugbank/property/271B4C15-363D-11E5-9242-09173F13E4C5
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http://linked.open...strongest-acidic-	http://linked.opendata.cz/resource/drugbank/property/271B4C11-363D-11E5-9242-09173F13E4C5
http://linked.open...-strongest-basic-	http://linked.opendata.cz/resource/drugbank/property/271B4C12-363D-11E5-9242-09173F13E4C5

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