About: L-Glutamic Acid     Goto   Sponge   NotDistinct   Permalink

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  • A peptide that is a homopolymer of glutamic acid. [PubChem] (en)
http://linked.open...generalReferences
  • # Smith QR: Transport of glutamate and other amino acids at the blood-brain barrier. J Nutr. 2000 Apr;130(4S Suppl):1016S-22S. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/10736373 # Okumoto S, Looger LL, Micheva KD, Reimer RJ, Smith SJ, Frommer WB: Detection of glutamate release from neurons by genetically encoded surface-displayed FRET nanosensors. Proc Natl Acad Sci U S A. 2005 Jun 14;102(24):8740-5. Epub 2005 Jun 6. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/15939876 # Reeds PJ, Burrin DG, Stoll B, Jahoor F: Intestinal glutamate metabolism. J Nutr. 2000 Apr;130(4S Suppl):978S-82S. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/10736365 # Corrie JE, DeSantis A, Katayama Y, Khodakhah K, Messenger JB, Ogden DC, Trentham DR: Postsynaptic activation at the squid giant synapse by photolytic release of L-glutamate from a 'caged' L-glutamate. J Physiol. 1993 Jun;465:1-8. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/7901400 # Augustin H, Grosjean Y, Chen K, Sheng Q, Featherstone DE: Nonvesicular release of glutamate by glial xCT transporters suppresses glutamate receptor clustering in vivo. J Neurosci. 2007 Jan 3;27(1):111-23. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/17202478 (en)
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  • nutraceutical (en)
http://linked.open...ugbank/indication
  • Considered to be nature's "Brain food" by improving mental capacities; helps speed the healing of ulcers; gives a "lift" from fatigue; helps control alcoholism, schizophrenia and the craving for sugar. (en)
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Title
  • L-Glutamic Acid (en)
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http://linked.open...mechanismOfAction
  • Glutamate activates both ionotropic and metabotropic glutamate receptors. The ionotropic ones being non-NMDA (AMPA and kainate) and NMDA receptors. Free glutamic acid cannot cross the blood-brain barrier in appreciable quantities; instead it is converted into L-glutamine, which the brain uses for fuel and protein synthesis. It is conjectured that glutamate is involved in cognitive functions like learning and memory in the brain, though excessive amounts may cause neuronal damage associated in diseases like amyotrophic lateral sclerosis, lathyrism, and Alzheimer's disease. Also, the drug phencyclidine (more commonly known as PCP) antagonizes glutamate at the NMDA receptor, causing behavior reminiscent of schizophrenia. Glutamate in action is extremely difficult to study due to its transient nature. (en)
http://linked.open...drugbank/packager
http://linked.open.../drugbank/synonym
  • (2S)-2-Aminopentanedioic acid (en)
  • (S)-2-Aminopentanedioic acid (en)
  • (S)-Glutamic acid (en)
  • Glutamic acid (en)
  • L-Glutamate (en)
  • L-Glutaminic acid (en)
  • Glu (en)
http://linked.open...drugbank/toxicity
  • Glutamate causes neuronal damage and eventual cell death, particularly when NMDA receptors are activated, High dosages of glutamic acid may include symptoms such as headaches and neurological problems. (en)
http://linked.open.../drug/hasAHFSCode
http://linked.open...ynthesisReference
  • Nobuharu Tujimoto, Yoshimi Kikuchi, Osamu Kurahashi, Yoshiko Kawahara, "Mutant Escherichia coli capable of enhanced L-glutamic acid production." U.S. Patent US5393671, issued August, 1960. (en)
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  • Absorbed from the lumen of the small intestine into the enterocytes.Absorption is efficient and occurs by an active transport mechanism. (en)
http://linked.open.../affectedOrganism
  • Humans and other mammals (en)
http://linked.open...casRegistryNumber
  • 56-86-0 (en)
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  • (en)
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