About: L-Tyrosine     Goto   Sponge   NotDistinct   Permalink

An Entity of Type : http://linked.opendata.cz/ontology/drugbank/Drug, within Data Space : linked.opendata.cz associated with source document(s)

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http://linked.open...gbank/description
  • A non-essential amino acid. In animals it is synthesized from phenylalanine. It is also the precursor of epinephrine; thyroid hormones; and melanin. [PubChem] (en)
http://linked.open...generalReferences
  • # Hoffhines AJ, Damoc E, Bridges KG, Leary JA, Moore KL: Detection and purification of tyrosine-sulfated proteins using a novel anti-sulfotyrosine monoclonal antibody. J Biol Chem. 2006 Dec 8;281(49):37877-87. Epub 2006 Oct 17. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/17046811 # Molnar GA, Wagner Z, Marko L, Ko Szegi T, Mohas M, Kocsis B, Matus Z, Wagner L, Tamasko M, Mazak I, Laczy B, Nagy J, Wittmann I: Urinary ortho-tyrosine excretion in diabetes mellitus and renal failure: evidence for hydroxyl radical production. Kidney Int. 2005 Nov;68(5):2281-7. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/16221230 # Molnar GA, Nemes V, Biro Z, Ludany A, Wagner Z, Wittmann I: Accumulation of the hydroxyl free radical markers meta-, ortho-tyrosine and DOPA in cataractous lenses is accompanied by a lower protein and phenylalanine content of the water-soluble phase. Free Radic Res. 2005 Dec;39(12):1359-66. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/16298866 (en)
http://linked.open...gy/drugbank/group
  • approved (en)
  • nutraceutical (en)
http://linked.open...ugbank/indication
  • Tyrosine is claimed to act as an effective antidepressant, however results are mixed. Tyrosine has also been claimed to reduce stress and combat narcolepsy and chronic fatigue, however these claims have been refuted by some studies. (en)
sameAs
Title
  • L-Tyrosine (en)
adms:identifier
http://linked.open...mechanismOfAction
  • Tyrosine is produced in cells by hydroxylating the essential amino acid phenylalanine. This relationship is much like that between cysteine and methionine. Half of the phenylalanine required goes into the production of tyrosine; if the diet is rich in tyrosine itself, the requirements for phenylalanine are reduced by about 50%. The mechanism of L-tyrosine's antidepressant activity can be accounted for by the precursor role of L-tyrosine in the synthesis of the neurotransmitters norepinephrine and dopamine. Elevated brain norepinephrine and dopamine levels are thought to be associated with antidepressant effects. (en)
http://linked.open...drugbank/packager
http://linked.open.../drugbank/synonym
  • TYROSINE (en)
  • L-Tyrosine (en)
  • Y (en)
  • (-)-alpha-amino-P-Hydroxyhydrocinnamic acid (en)
  • (2S)-2-amino-3-(4-hydroxyphenyl)propanoic acid (en)
  • (S)-(-)-Tyrosine (en)
  • (S)-2-Amino-3-(p-hydroxyphenyl)propionic acid (en)
  • (S)-3-(p-Hydroxyphenyl)alanine (en)
  • (S)-Tyrosine (en)
  • (S)-alpha-amino-4-Hydroxybenzenepropanoic acid (en)
  • (S)-α-amino-4-hydroxybenzenepropanoic acid (en)
  • (−)-α-amino-p-hydroxyhydrocinnamic acid (en)
  • 4-hydroxy-L-phenylalanine (en)
  • L-Tyrosin (en)
  • Tyr (en)
http://linked.open...drugbank/toxicity
  • L-Tyrosine has very low toxicity. There have been very few reports of toxicity. LD<sub>50</sub> (oral, rat) > 5110 mg/kg. (en)
http://linked.open...ynthesisReference
  • Hai-quan Mao, Kam W. Leong, "Biodegradable poly (phosphoester-co-desaminotyrosyl L-tyrosine ester) compounds, compositions, articles and methods for making and using the same." U.S. Patent US5912225, issued May, 1960. (en)
http://linked.open...y/mesh/hasConcept
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http://linked.open...ugbank/IUPAC-Name
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http://linked.open...bank/Refractivity
http://linked.open...atable-Bond-Count
http://linked.open...ugbank/absorption
  • L-tyrosine is absorbed from the small intestine by a sodium-dependent active transport process. (en)
http://linked.open.../affectedOrganism
  • Humans and other mammals (en)
http://linked.open...casRegistryNumber
  • 60-18-4 (en)
http://linked.open...drugbank/category
  • (en)
http://linked.open...gbank/containedIn
http://linked.open...k/Bioavailability
http://linked.open...bank/Ghose-Filter
http://linked.open...nk/MDDR-Like-Rule
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http://linked.open...bank/Rule-of-Five
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http://linked.open...strongest-acidic-
http://linked.open...-strongest-basic-
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