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An Entity of Type : http://linked.opendata.cz/ontology/drugbank/Drug, within Data Space : linked.opendata.cz associated with source document(s)

AttributesValues
rdf:type
http://linked.open...gbank/description
  • A six carbon compound related to glucose. It is found naturally in citrus fruits and many vegetables. Ascorbic acid is an essential nutrient in human diets, and necessary to maintain connective tissue and bone. Its biologically active form, vitamin C, functions as a reducing agent and coenzyme in several metabolic pathways. Vitamin C is considered an antioxidant. [PubChem] (en)
http://linked.open...y/drugbank/dosage
http://linked.open...generalReferences
  • # Padayatty SJ, Katz A, Wang Y, Eck P, Kwon O, Lee JH, Chen S, Corpe C, Dutta A, Dutta SK, Levine M: Vitamin C as an antioxidant: evaluation of its role in disease prevention. J Am Coll Nutr. 2003 Feb;22(1):18-35. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/12569111 # Meister A: Glutathione-ascorbic acid antioxidant system in animals. J Biol Chem. 1994 Apr 1;269(13):9397-400. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/8144521 # Englard S, Seifter S: The biochemical functions of ascorbic acid. Annu Rev Nutr. 1986;6:365-406. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/3015170 # Banhegyi G, Mandl J: The hepatic glycogenoreticular system. Pathol Oncol Res. 2001;7(2):107-10. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/11458272 # Proctor P: Similar functions of uric acid and ascorbate in man? Nature. 1970 Nov 28;228(5274):868. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/5477017 # Korcok J, Dixon SJ, Lo TC, Wilson JX: Differential effects of glucose on dehydroascorbic acid transport and intracellular ascorbate accumulation in astrocytes and skeletal myocytes. Brain Res. 2003 Dec 12;993(1-2):201-7. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/14642847 (en)
http://linked.open...gy/drugbank/group
  • approved (en)
  • nutraceutical (en)
http://linked.open...drugbank/halfLife
  • 16 days (3.4 hours in people who have excess levels of vitamin C) (en)
http://linked.open...ugbank/indication
  • Used to treat vitamin C deficiency, scurvy, delayed wound and bone healing, urine acidification, and in general as an antioxidant. It has also been suggested to be an effective antiviral agent. (en)
sameAs
Title
  • Vitamin C (en)
adms:identifier
http://linked.open...mechanismOfAction
  • In humans, an exogenous source of ascorbic acid is required for collagen formation and tissue repair by acting as a cofactor in the posttranslational formation of 4-hydroxyproline in -Xaa-Pro-Gly- sequences in collagens and other proteins. Ascorbic acid is reversibly oxidized to dehydroascorbic acid in the body. These two forms of the vitamin are believed to be important in oxidation-reduction reactions. The vitamin is involved in tyrosine metabolism, conversion of folic acid to folinic acid, carbohydrate metabolism, synthesis of lipids and proteins, iron metabolism, resistance to infections, and cellular respiration. (en)
http://linked.open...drugbank/packager
http://linked.open.../drugbank/synonym
  • Vitamin C (en)
  • Ascoltin (en)
  • Ascorbicap (en)
  • Ascorbate (en)
  • Ascorbic Acid (en)
  • L-Ascorbate (en)
  • L-Ascorbic Acid (en)
  • Acide ascorbique (en)
  • Acido ascorbico (en)
  • Acidum ascorbicum (en)
  • Acidum ascorbinicum (en)
  • Ascorbinsaeure (en)
  • L-(+)-ascorbic acid (en)
  • e 300 (en)
  • e-300 (en)
  • e300 (en)
http://linked.open.../drug/hasAHFSCode
http://linked.open...nk/proteinBinding
  • 25% (en)
http://linked.open...ynthesisReference
  • Lewis D. Morse, Paul A. Hammes, "Beverage containing stabilized vitamin C and iron and method of making same." U.S. Patent US3958017, issued October, 1972. (en)
http://linked.open...y/mesh/hasConcept
foaf:page
http://linked.open...ugbank/IUPAC-Name
http://linked.open...gy/drugbank/InChI
http://linked.open...Molecular-Formula
http://linked.open.../Molecular-Weight
http://linked.open...noisotopic-Weight
http://linked.open...y/drugbank/SMILES
http://linked.open.../Water-Solubility
http://linked.open...ogy/drugbank/logP
http://linked.open...ogy/drugbank/logS
http://linked.open...logy/drugbank/pKa
http://linked.open...l/drug/hasATCCode
http://linked.open...nd-Acceptor-Count
http://linked.open...-Bond-Donor-Count
http://linked.open...drugbank/InChIKey
http://linked.open...urface-Area--PSA-
http://linked.open...nk/Polarizability
http://linked.open...bank/Refractivity
http://linked.open...atable-Bond-Count
http://linked.open...ugbank/absorption
  • 70% to 90% (en)
http://linked.open.../affectedOrganism
  • Humans and other mammals (en)
http://linked.open...casRegistryNumber
  • 50-81-7 (en)
http://linked.open...drugbank/category
  • (en)
http://linked.open...gbank/containedIn
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