About: Pyruvic acid

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An Entity of Type : http://linked.opendata.cz/ontology/drugbank/Drug, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	http://linked.opendata.cz/ontology/drugbank/Drug
http://linked.open...gbank/description	An intermediate compound in the metabolism of carbohydrates, proteins, and fats. In thiamine deficiency, its oxidation is retarded and it accumulates in the tissues, especially in nervous structures. (From Stedman, 26th ed) (en)
http://linked.open...gy/drugbank/group	approved (en) nutraceutical (en)
http://linked.open...ugbank/indication	For nutritional supplementation, also for treating dietary shortage or imbalance (en)
sameAs	Pyruvic acid Pyruvic acid
Title	Pyruvic acid (en)
adms:identifier	http://linked.opendata.cz/resource/drugbank/drug/DB00119/identifier/bindingdb/19473 http://linked.opendata.cz/resource/drugbank/drug/DB00119/identifier/chebi/32816 http://linked.opendata.cz/resource/drugbank/drug/DB00119/identifier/chemspider/1031 http://linked.opendata.cz/resource/drugbank/drug/DB00119/identifier/drugbank/DB00119 http://linked.opendata.cz/resource/drugbank/drug/DB00119/identifier/kegg-compound/C00022 http://linked.opendata.cz/resource/drugbank/drug/DB00119/identifier/pdb/PYR http://linked.opendata.cz/resource/drugbank/drug/DB00119/identifier/pubchem-compound/1060 http://linked.opendata.cz/resource/drugbank/drug/DB00119/identifier/pubchem-substance/46505692 http://linked.opendata.cz/resource/drugbank/drug/DB00119/identifier/pharmgkb/PA164778686 http://linked.opendata.cz/resource/drugbank/drug/DB00119/identifier/wikipedia/Pyruvic_acid
http://linked.open...mechanismOfAction	Pyruvate serves as a biological fuel by being converted to acetyl coenzyme A, which enters the tricarboxylic acid or Krebs cycle where it is metabolized to produce ATP aerobically. Energy can also be obtained anaerobically from pyruvate via its conversion to lactate. Pyruvate injections or perfusions increase contractile function of hearts when metabolizing glucose or fatty acids. This inotropic effect is striking in hearts stunned by ischemia/reperfusion. The inotropic effect of pyruvate requires intracoronary infusion. Among possible mechanisms for this effect are increased generation of ATP and an increase in ATP phosphorylation potential. Another is activation of pyruvate dehydrogenase, promoting its own oxidation by inhibiting pyruvate dehydrogenase kinase. Pyruvate dehydrogenase is inactivated in ischemia myocardium. Yet another is reduction of cytosolic inorganic phosphate concentration. Pyruvate, as an antioxidant, is known to scavenge such reactive oxygen species as hydrogen peroxide and lipid peroxides. Indirectly, supraphysiological levels of pyruvate may increase cellular reduced glutathione. (en)
http://linked.open.../drugbank/synonym	Pyruvic acid (en) 2-Oxopropanoic acid (en) Acetylformic acid (en) BTS (en) Pyroracemic acid (en) a-Ketopropionic acid (en) 2-Oxopropansaeure (en) 2-Oxopropionsaeure (en) 2-ketopropionic acid (en) Acide pyruvique (en) Brenztraubensaeure (en) CH3COCOOH (en) alpha-Ketopropionic acid (en) alpha-Oxopropionsaeure (en) α-ketopropionic acid (en)
http://linked.open...drugbank/toxicity	Those taking large doses of supplemental pyruvate—usually greater than 5 grams daily—have reported gastrointestinal symptoms, including abdominal discomfort and bloating, gas and diarrhea. One child receiving pyruvate intravenously for restrictive cardiomyopathy died. (en)
http://linked.open...ynthesisReference	Tadamitsu Kiyoura, "Process for producing salts of pyruvic acid." U.S. Patent US4242525, issued December, 1965. (en)
http://linked.open...y/mesh/hasConcept	http://linked.opendata.cz/resource/mesh/concept/M0028719
foaf:page	http://www.pdrhealth.com/drug_info/nmdrugprofiles/nutsupdrugs/pyr_0218.shtml
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http://linked.open...ugbank/absorption	Pyruvate is absorbed from the gastrointestinal tract from whence it is transported to the liver via the portal circulation. (en)
http://linked.open.../affectedOrganism	Humans and other mammals (en)
http://linked.open...casRegistryNumber	127-17-3 (en)
http://linked.open...drugbank/category	(en)
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