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An Entity of Type : http://linked.opendata.cz/ontology/drugbank/Drug, within Data Space : linked.opendata.cz associated with source document(s)

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http://linked.open...gbank/description
  • Physiologic methyl radical donor involved in enzymatic transmethylation reactions and present in all living organisms. It possesses anti-inflammatory activity and has been used in treatment of chronic liver disease. (From Merck, 11th ed) (en)
http://linked.open...generalReferences
  • # Finkelstein JD, Martin JJ: Homocysteine. Int J Biochem Cell Biol. 2000 Apr;32(4):385-9. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/10762063 # Fodinger M, Horl WH, Sunder-Plassmann G: Molecular biology of 5,10-methylenetetrahydrofolate reductase. J Nephrol. 2000 Jan-Feb;13(1):20-33. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/10720211 # Roje S: S-Adenosyl-L-methionine: beyond the universal methyl group donor. Phytochemistry. 2006 Aug;67(15):1686-98. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/16766004 # Loenen WA: S-adenosylmethionine: jack of all trades and master of everything? Biochem Soc Trans. 2006 Apr;34(Pt 2):330-3. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/16545107 # Chiang PK, Gordon RK, Tal J, Zeng GC, Doctor BP, Pardhasaradhi K, McCann PP: S-Adenosylmethionine and methylation. FASEB J. 1996 Mar;10(4):471-80. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/8647346 (en)
http://linked.open...gy/drugbank/group
  • approved (en)
  • nutraceutical (en)
http://linked.open...ugbank/indication
  • S-Adenosylmethionine (SAMe) is used as a drug in Europe for the treatment of depression, liver disorders, fibromyalgia, and osteoarthritis. It has also been introduced into the United States market as a dietary supplement for the support of bone and joint health, as well as mood and emotional well being. (en)
sameAs
Title
  • S-Adenosylmethionine (en)
adms:identifier
http://linked.open...mechanismOfAction
  • S-Adenosylmethionine (SAMe) is a natural substance present in the cells of the body. It is a direct metabolite of the essential amino acid L-methionine. SAMe plays a crucial biochemical role in the body by donating a one-carbon methyl group in a process called transmethylation. SAMe, formed from the reaction of L-methionine and adenosine triphosphate catalyzed by the enzyme S-adenosylmethionine synthetase, is the methyl-group donor in the biosynthesis of both DNA and RNA nucleic acids, phospholipids, proteins, epinephrine, melatonin, creatine and other molecules. (en)
http://linked.open...drugbank/packager
http://linked.open.../drugbank/synonym
  • S-Adenosylmethionine (en)
  • Acylcarnitine (en)
  • AdoMet (en)
  • S-adenosyl-L-methionine (en)
  • SAM (en)
  • SAMe (en)
  • S-(5'-Deoxyadenosin-5'-yl)-L-methionine (en)
  • [1-(Adenin-9-yl)-1,5-dideoxy-beta-D-ribofuranos-5-yl][(3S)-3-amino-3-carboxypropyl](methyl)sulfonium (en)
  • (3S)-5'-[(3-amino-3-Carboxypropyl)methylsulfonio]-5'-deoxyadenosine, inner salt (en)
http://linked.open...drugbank/toxicity
  • Irritating to mucus membranes and upper respiratory tract. Can cause CNS depression. (en)
http://linked.open...ogy/drugbank/salt
  • (en)
http://linked.open...ynthesisReference
  • Takayasu Tsuchida, Fumihiro Yoshinaga, Shinji Okumura, "Method for producing S-adenosylmethionine or methylthioadenosine by yeast." U.S. Patent US3962034, issued November, 1971. (en)
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http://linked.open...ugbank/absorption
  • S-Adenosylmethionine is absorbed from the small intestine following oral intake. As absorption is affected by food, it is best to take on an empty stomach. Bioavailability is low following oral intake. (en)
http://linked.open.../affectedOrganism
  • Humans and other mammals (en)
http://linked.open...casRegistryNumber
  • 29908-03-0 (en)
http://linked.open...drugbank/category
  • (en)
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