About: Becaplermin

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About: Becaplermin Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/drugbank/Drug, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	http://linked.opendata.cz/ontology/drugbank/Drug
http://linked.open...gbank/description	Becaplermin is produced by recombinant DNA technology by insertion of the gene for the B chain of platelet derived growth factor (PDGF) into the yeast, Saccharomyces cerevisiae. Becaplermin has a molecular weight of approximately 25 KD and is a homodimer composed of two identical polypeptide chains that are bound together by disulfide bonds (en)
http://linked.open...y/drugbank/dosage	http://linked.opendata.cz/resource/drugbank/dosage/271B453F-363D-11E5-9242-09173F13E4C5
http://linked.open...generalReferences	# http://www.ema.europa.eu/docs/en_GB/document_library/EPAR_-_Scientific_Discussion/human/000212/WC500050140.pdf #Lexicomp [Internet]. Becaplermin. 2014 [cited 12 November 2014]. Available from: http://online.lexi.com.login.ezproxy.library.ualberta.ca/lco/action/doc/retrieve/docid/patch_f/6420#f_pharmacology-and-pharmacokinetics (en)
http://linked.open...gy/drugbank/group	approved (en) investigational (en)
http://linked.open...ugbank/indication	For topical treatment of skin ulcers (from diabetes) (en)
sameAs	Becaplermin Becaplermin
Title	Becaplermin (en)
adms:identifier	http://linked.opendata.cz/resource/drugbank/drug/DB00102/identifier/drugbank/DB00102 http://linked.opendata.cz/resource/drugbank/drug/DB00102/identifier/genbank/K01401 http://linked.opendata.cz/resource/drugbank/drug/DB00102/identifier/uniprotkb/P01127 http://linked.opendata.cz/resource/drugbank/drug/DB00102/identifier/pharmgkb/PA164749511 http://linked.opendata.cz/resource/drugbank/drug/DB00102/identifier/wikipedia/Becaplermin
http://linked.open...mechanismOfAction	Binds to the beta platelet-derived growth factor (PDGF) receptor, a tyrosine kinase receptor. PDGF is known to exist as a dimer, and activates its signaling pathway by a ligand induced receptor dimerization and autophosphorylation. PDGF receptors also contain many auto-phosphorylation sites, which serve to mediate binding of SH2 sites and subsequently signal corresponding pathways. There are five different isoforms of PDGF that activate through two different receptors (alpha and beta). (en)
http://linked.open...drugbank/packager	Diversified Healthcare Services Inc. Excellium Pharmaceutical Inc. Heartland Repack Services LLC A-S Medication Solutions LLC Accord Healthcare
http://linked.open...y/drugbank/patent	http://linked.opendata.cz/resource/drugbank/patent/1340846
http://linked.open.../drugbank/synonym	PDGF B-chain (en) PDGF-2 (en) Platelet-derived growth factor B chain precursor (en) Platelet-derived growth factor beta polypeptide (en) c-sis (en)
http://linked.open.../drug/hasAHFSCode	http://linked.opendata.cz/resource/AHFS/84-16-00
http://linked.open...y/mesh/hasConcept	http://linked.opendata.cz/resource/mesh/concept/M0195683
foaf:page	http://www.drugs.com/cdi/becaplermin.html http://www.rxlist.com/cgi/generic2/becapler.htm
http://linked.open...Molecular-Formula	http://linked.opendata.cz/resource/drugbank/property/271B4543-363D-11E5-9242-09173F13E4C5
http://linked.open.../Molecular-Weight	http://linked.opendata.cz/resource/drugbank/property/271B4542-363D-11E5-9242-09173F13E4C5
http://linked.open...l/drug/hasATCCode	Becaplermin Becaplermin
http://linked.open...ugbank/absorption	very little systemic absorption. 15% of patients experienced complete healing within 8 weeks, while for 25% of patients, it was at 10 weeks. (en)
http://linked.open.../affectedOrganism	Humans and other mammals (en)
http://linked.open...casRegistryNumber	165101-51-9 (en)
http://linked.open...drugbank/category	(en)
http://linked.open...gbank/containedIn	Regranex 0.01% gel Regranex 0.01% Gel 15 gm Tube
http://linked.open...nk/Hydrophobicity	http://linked.opendata.cz/resource/drugbank/property/271B4540-363D-11E5-9242-09173F13E4C5
http://linked.open...Isoelectric-Point	http://linked.opendata.cz/resource/drugbank/property/271B4541-363D-11E5-9242-09173F13E4C5

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