About: Choriogonadotropin alfa

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An Entity of Type : http://linked.opendata.cz/ontology/drugbank/Drug, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	http://linked.opendata.cz/ontology/drugbank/Drug
http://linked.open...gbank/description	Recombinant human chorionic gonadotropin with 2 subunits, alpha = 92 residues, beta = 145 residues, each with N-and O-linked carbohydrate moieties linked to ASN-52 and ASN-78 (on alpha subunit) and ASN-13, ASN-30, SER-121, SER-127, SER-132 and SER-138 (on beta subunit). The primary structure of the alpha-chain of r-hCG is identical to that of the alpha-chain of hCG, FSH and LH. (en)
http://linked.open...y/drugbank/dosage	http://linked.opendata.cz/resource/drugbank/dosage/271B4505-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/dosage/271B4506-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/dosage/271B4507-363D-11E5-9242-09173F13E4C5
http://linked.open...generalReferences	# Kayisli UA, Selam B, Guzeloglu-Kayisli O, Demir R, Arici A: Human chorionic gonadotropin contributes to maternal immunotolerance and endometrial apoptosis by regulating Fas-Fas ligand system. J Immunol. 2003 Sep 1;171(5):2305-13. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/12928375 # Askling J, Erlandsson G, Kaijser M, Akre O, Ekbom A: Sickness in pregnancy and sex of child. Lancet. 1999 Dec 11;354(9195):2053. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/10636378 (en)
http://linked.open...gy/drugbank/group	approved (en)
http://linked.open...drugbank/halfLife	The mean terminal half-life is about 29 ± 6 hours (initial half-life is 4.5 ± 0.5 hours). (en)
http://linked.open...ugbank/indication	For the treatment of female infertility (en)
http://linked.open...bank/manufacturer	Barr Pharmaceuticals Blenheim Pharmacal App pharmaceuticals llc Bel mar laboratories inc Bristol myers squibb Cardinal Health
sameAs	Choriogonadotropin alfa Choriogonadotropin alfa
Title	Choriogonadotropin alfa (en)
adms:identifier	http://linked.opendata.cz/resource/drugbank/drug/DB00097/identifier/drugbank/DB00097 http://linked.opendata.cz/resource/drugbank/drug/DB00097/identifier/genbank/J00117 http://linked.opendata.cz/resource/drugbank/drug/DB00097/identifier/national-drug-code-directory/44087-1150-1 http://linked.opendata.cz/resource/drugbank/drug/DB00097/identifier/uniprotkb/P01233 http://linked.opendata.cz/resource/drugbank/drug/DB00097/identifier/pharmgkb/PA164783947 http://linked.opendata.cz/resource/drugbank/drug/DB00097/identifier/wikipedia/Choriogonadotropin_alfa
http://linked.open...mechanismOfAction	Choriogonadotropin alfa binds to the Follicle stimulating hormone receptor which results in ovulation in the absence of sufficient endogenous Luteinizing hormone. (en)
http://linked.open...drugbank/packager	Pfizer Inc. Atlantic Biologicals Corporation Aurobindo Pharma Ltd. Avkare Incorporated
http://linked.open...y/drugbank/patent	http://linked.opendata.cz/resource/drugbank/patent/5767251 http://linked.opendata.cz/resource/drugbank/patent/6706681
http://linked.open...outeOfElimination	One-tenth of the dose is excreted in the urine. (en)
http://linked.open.../drugbank/synonym	CG-beta (en) Choriogonadotropin beta chain precursor (en) Chorionic gonadotrophin beta subunit (en)
http://linked.open...umeOfDistribution	* 5.9 ± 1.0 L (en)
foaf:page	http://www.drugs.com/cdi/choriogonadotropin-alfa.html http://www.rxlist.com/cgi/generic/ovidrel.htm
http://linked.open...Molecular-Formula	http://linked.opendata.cz/resource/drugbank/property/271B450C-363D-11E5-9242-09173F13E4C5
http://linked.open.../Molecular-Weight	http://linked.opendata.cz/resource/drugbank/property/271B450B-363D-11E5-9242-09173F13E4C5
http://linked.open...l/drug/hasATCCode	Choriogonadotropin alfa
http://linked.open...ugbank/absorption	The mean absolute bioavailability following a single subcutaneous injection to healthy female volunteers is about 40%. (en)
http://linked.open.../affectedOrganism	Humans and other mammals (en)
http://linked.open...casRegistryNumber	177073-44-8 (en)
http://linked.open...drugbank/category	(en)
http://linked.open...rugbank/clearance	* 0.29 +/- 0.04 L/h [healthy down-regulated females] (en)
http://linked.open...gbank/containedIn	Niravam 0.25 mg Dispersible Tablet Pregnyl 10000 unit Solution Ovidrel 250 mcg/0.5ml Injectable 0.5ml Syringe ALPRAZolam 3 mg 24 Hour tablet Novarel 10000 unit/10ml Solution 1 Vial = 10ml
http://linked.open...nk/Hydrophobicity	http://linked.opendata.cz/resource/drugbank/property/271B4509-363D-11E5-9242-09173F13E4C5
http://linked.open...Isoelectric-Point	http://linked.opendata.cz/resource/drugbank/property/271B450A-363D-11E5-9242-09173F13E4C5
http://linked.open...ank/Melting-Point	http://linked.opendata.cz/resource/drugbank/property/271B4508-363D-11E5-9242-09173F13E4C5

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