About: Laronidase

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About: Laronidase Goto Sponge NotDistinct Permalink

An Entity of Type : http://linked.opendata.cz/ontology/drugbank/Drug, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	http://linked.opendata.cz/ontology/drugbank/Drug
http://linked.open...gbank/description	Human recombinant alpha-L-iduronidase, 628 residues (mature form), produced by recombinant DNAtechnology in a Chinese hamster ovary cell line. Laronidase is a glycoprotein with a molecular weight of approximately 83 kD. The predicted amino acid sequence of the recombinant form, as well as the nucleotide sequence that encodes it, are identical to a polymorphic form of human a-L-iduronidase. It contains 6 N-linked oligosaccharide modification sites. (en)
http://linked.open...y/drugbank/dosage	http://linked.opendata.cz/resource/drugbank/dosage/271B4439-363D-11E5-9242-09173F13E4C5 http://linked.opendata.cz/resource/drugbank/dosage/271B443A-363D-11E5-9242-09173F13E4C5
http://linked.open...generalReferences	# Clarke LA, Wraith JE, Beck M, Kolodny EH, Pastores GM, Muenzer J, Rapoport DM, Berger KI, Sidman M, Kakkis ED, Cox GF: Long-term efficacy and safety of laronidase in the treatment of mucopolysaccharidosis I. Pediatrics. 2009 Jan;123(1):229-40. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/19117887 # Landry Y, Gies JP: Drugs and their molecular targets: an updated overview. Fundam Clin Pharmacol. 2008 Feb;22(1):1-18. "Pubmed":http://www.ncbi.nlm.nih.gov/pubmed/18251718 (en)
http://linked.open...gy/drugbank/group	approved (en)
http://linked.open...drugbank/halfLife	1.5-3.6 hrs (en)
http://linked.open...ugbank/indication	For the treatment of mucopolysaccharidosis (en)
sameAs	Laronidase Laronidase
Title	Laronidase (en)
adms:identifier	http://linked.opendata.cz/resource/drugbank/drug/DB00090/identifier/drugbank/DB00090 http://linked.opendata.cz/resource/drugbank/drug/DB00090/identifier/genbank/M74715 http://linked.opendata.cz/resource/drugbank/drug/DB00090/identifier/uniprotkb/P35475 http://linked.opendata.cz/resource/drugbank/drug/DB00090/identifier/pharmgkb/PA164776670 http://linked.opendata.cz/resource/drugbank/drug/DB00090/identifier/wikipedia/Laronidase
http://linked.open...mechanismOfAction	Laronidase catalyses the hydrolysis of terminal alpha-L-iduronic acid residues of dermatan sulfate and heparin sulfate. (en)
http://linked.open...drugbank/packager	BioMarin Pharmaceuticals Inc. Ben venue laboratories inc Claris lifesciences ltd
http://linked.open.../drugbank/synonym	Alpha-L-iduronidase precursor (en)
http://linked.open.../drug/hasAHFSCode	http://linked.opendata.cz/resource/AHFS/44-00-00
foaf:page	http://www.drugs.com/cdi/laronidase.html http://www.rxlist.com/cgi/generic3/aldurazyme.htm
http://linked.open...Molecular-Formula	http://linked.opendata.cz/resource/drugbank/property/271B443E-363D-11E5-9242-09173F13E4C5
http://linked.open.../Molecular-Weight	http://linked.opendata.cz/resource/drugbank/property/271B443D-363D-11E5-9242-09173F13E4C5
http://linked.open...l/drug/hasATCCode	Laronidase
http://linked.open.../affectedOrganism	Humans and other mammals (en)
http://linked.open...casRegistryNumber	210589-09-6 (en)
http://linked.open...drugbank/category	(en)
http://linked.open...gbank/containedIn	Aldurazyme 2.9 mg/5 ml vial
http://linked.open...nk/Hydrophobicity	http://linked.opendata.cz/resource/drugbank/property/271B443B-363D-11E5-9242-09173F13E4C5
http://linked.open...Isoelectric-Point	http://linked.opendata.cz/resource/drugbank/property/271B443C-363D-11E5-9242-09173F13E4C5

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